From: A gated group sequential design for seamless Phase II/III trial with subpopulation selection
 | Setting 1 | Setting 2 | Setting 3 | ||||
---|---|---|---|---|---|---|---|
Weight(\({w}_{1k},{w}_{2k}\)) | Design | S | S & F | S | S & F | S | |
PFS | OS | GSD | 0.877 | 0.873 | 0.908 | 0.908 | 0.908 |
(\({w}_{1k}^{PFS},{w}_{2k}^{PFS}\))a | (\({w}_{1k}^{OS},{w}_{2k}^{OS}\))a | AD | 0.903 | 0.914 | 0.945 | 0.947 | 0.908 |
gGSD | 0.914 | 0.925 | 0.945 | 0.947 | 0.908 | ||
(\(\sqrt{0.2},\sqrt{0.8}\)) | (\(\sqrt{0.2},\sqrt{0.8}\)) | AD | 0.749 | 0.750 | 0.830 | 0.830 | 0.798 |
gGSD | 0.769 | 0.770 | 0.829 | 0.829 | 0.798 | ||
(\(\sqrt{0.3},\sqrt{0.7}\)) | (\(\sqrt{0.3},\sqrt{0.7}\)) | AD | 0.808 | 0.813 | 0.877 | 0.878 | 0.844 |
gGSD | 0.826 | 0.830 | 0.877 | 0.878 | 0.846 | ||
(\(\sqrt{0.5},\sqrt{0.5}\)) | (\(\sqrt{0.5},\sqrt{0.5}\)) | AD | 0.873 | 0.881 | 0.928 | 0.930 | 0.895 |
gGSD | 0.888 | 0.895 | 0.929 | 0.930 | 0.895 | ||
(\(\sqrt{0.5},\sqrt{0.5}\)) | (\(\sqrt{0.7},\sqrt{0.3}\)) | AD | 0.894 | 0.903 | 0.939 | 0.941 | 0.904 |
gGSD | 0.908 | 0.916 | 0.938 | 0.940 | 0.904 | ||
(\(\sqrt{0.7},\sqrt{0.3}\)) | (\(\sqrt{0.7},\sqrt{0.3}\)) | AD | 0.900 | 0.910 | 0.945 | 0.947 | 0.908 |
gGSD | 0.913 | 0.922 | 0.945 | 0.947 | 0.909 | ||
(\(\sqrt{0.8},\sqrt{0.2}\)) | (\(\sqrt{0.8},\sqrt{0.2}\)) | AD | 0.903 | 0.914 | 0.945 | 0.948 | 0.905 |
gGSD | 0.915 | 0.925 | 0.946 | 0.948 | 0.906 | ||
(\(\sqrt{0.6},\sqrt{0.4}\)) | (\(\sqrt{0.6},\sqrt{0.4}\)) | AD | 0.890 | 0.899 | 0.939 | 0.941 | 0.903 |
gGSD | 0.904 | 0.913 | 0.939 | 0.941 | 0.904 |