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Table 6 Characteristics of COVID-19 related hospitalized patients, by months of prior available history

From: Data quality considerations for evaluating COVID-19 treatments using real world data: learnings from the National COVID Cohort Collaborative (N3C)

Variable

No history

N = 12523a

1-23 mo history

N = 9784a

24+ mo history

N = 21155a

p-valueb

Age

   

< 0.001

 18-49

3956 (32%)

3154 (32%)

4415 (21%)

 

 50-59

2485 (20%)

1550 (16%)

3462 (16%)

 

 60-69

2663 (21%)

2021 (21%)

4595 (22%)

 

  ≥ 70

3419 (27%)

3059 (31%)

8683 (41%)

 

Sex

   

< 0.001

 Female

4862 (39%)

4894 (50%)

11,190 (53%)

 

 Male

7661 (61%)

4890 (50%)

9965 (47%)

 

Race

   

< 0.001

 Asian

566 (4.5%)

359 (3.7%)

603 (2.9%)

 

 Black or African American

2337 (19%)

2147 (22%)

5106 (24%)

 

 White

5617 (45%)

4893 (50%)

12,418 (59%)

 

 Other/Unknown

4003 (32%)

2385 (24%)

3028 (14%)

 

Ethnicity

   

< 0.001

 Hispanic or Latino

3226 (26%)

2278 (23%)

3107 (15%)

 

 Not Hispanic or Latino

8133 (65%)

6852 (70%)

17,559 (83%)

 

 Unknown

1164 (9.3%)

654 (6.7%)

489 (2.3%)

 

BMI

   

< 0.001

  < 25

2060 (16%)

1944 (20%)

3968 (19%)

 

 25-29

2756 (22%)

2149 (22%)

4575 (22%)

 

 30-34

2162 (17%)

1660 (17%)

3462 (16%)

 

 35-39

1196 (9.6%)

891 (9.1%)

2006 (9.5%)

 

  ≥ 40

1162 (9.3%)

912 (9.3%)

2217 (10%)

 

 Missing

3187 (25%)

2228 (23%)

4927 (23%)

 

Hypertension

5605 (45%)

5729 (59%)

15,576 (74%)

< 0.001

Diabetes

4173 (33%)

3524 (36%)

9612 (45%)

< 0.001

CAD

1380 (11%)

1837 (19%)

6321 (30%)

< 0.001

CHF

1690 (13%)

2045 (21%)

6424 (30%)

< 0.001

COPD

924 (7.4%)

1168 (12%)

3888 (18%)

< 0.001

Cerebrovascular disease

848 (6.8%)

1149 (12%)

4059 (19%)

< 0.001

CKD

1637 (13%)

2183 (22%)

7303 (35%)

< 0.001

Cardiac arrhythmia

3636 (29%)

3386 (35%)

9942 (47%)

< 0.001

Tobacco smoking

770 (6.1%)

1142 (12%)

2506 (12%)

< 0.001

Malignancy

744 (5.9%)

1578 (16%)

4452 (21%)

< 0.001

Prior ACEI treatment

494 (3.9%)

1431 (15%)

5284 (25%)

< 0.001

Prior ARB treatment

391 (3.1%)

1067 (11%)

4071 (19%)

< 0.001

Prior statin treatment

829 (6.6%)

2551 (26%)

9475 (45%)

< 0.001

Ventilated on admissionc

2361 (19%)

894 (9.1%)

1852 (8.8%)

< 0.001

In-hospital mortality

1785 (14%)

1058 (11%)

2390 (11%)

< 0.001

  1. Abbreviations: CAD Coronary artery disease, CHF Congestive heart failure, COPD Chronic obstructive pulmonary disease, CKD Chronic kidney disease, ACEI Angiotensin-converting enzyme inhibitor, ARB Angiotensin 2 receptor blocker
  2. aStatistics presented: n (%)
  3. bStatistical tests performed: Kruskal-Wallis test; chi-square test of independence
  4. cInvasive mechanical ventilation and ECMO were defined as the terms included in the concept sets provided in supplemental Tables S1 and S2