Towards full clinical trial registration and results publication: longitudinal meta-research study in Northwestern and Central Switzerland

Table 3 Associations between trial characteristics and registration status in logistic regression

Characteristics^a	Registered n = 432	Non- registered n = 41	Univariable			Multivariable^b
Characteristics^a	Registered n = 432	Non- registered n = 41	OR	95% CI	p-value	OR	95% CI	p-value
Single center (compared to multicenter)	219 (85.9%)	36 (14.1%)	0.14	0.05-0.34	< 0.001	0.20	0.064-0.60	0.003
Investigator (compared to industry) sponsorship	306 (89.5%)	36 (10.5%)	0.34	0.11-0.81	0.026	1.66	0.64-7.59	0.42
Risk category low	201 (84.5%)	37 (15.5%)	Reference			Reference
Risk category intermediate	81 (97.6%)	2 (2.4%)	7.45	2.21-46.52	0.006	5.26	1.74-37.54	0.026
Risk category high	150 (98.7%)	2 (1.3%)	13.81	4.14-85.74	< 0.001	9.00	2.56-71.32	0.008
Use of CTU service (compared to. no service)	103 (99.0%)	1 (1.0%)	12.52	2.67-223.52	0.013	15.63	3.24-281.23	0.007

Abbreviations: OR odds ratio, CI confidence, CTU Clinical Trials Unit
^aReference values: sample size < 100, multi-center trials, investigator-initiated trials and drug trials
^bThe variables Single center/ Multicenter, Sponsorship, Risk category, and Use of CTU services were included in the multivariable logistic regression

ISSN: 1471-2288