HRQoL score trajectory | Risk of dropout | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Time effect | Arm-by-time interaction effect | Arm effect | Association with HRQoL | |||||||||
LMM | JM | LMM | JM | JM | JM | |||||||
\({\hat{\beta}}_1\) [95% CI] | p | \({\hat{\beta}}_1\) [95% CI] | p | \({\hat{\beta}}_2\) [95% CI] | p | \({\hat{\beta}}_2\) [95% CI] | p | \({\hat{\gamma}}_1\) [95% CI] | p | \(\hat{\alpha}\) [95% CI] | p | |
GLOBAL HEALTH STATUS/HRQoL | ||||||||||||
Global health status/HRQoL | 0.63 [− 0.17; 1.42] | 0.121 | 0.31 [− 0.45; 1.07] | 0.420 | 1.18 [0.25; 2.10] | 0.013 | 1.19 [0.34; 2.03] | 0.006 | −0.43 [− 0.72; − 0.15] | 0.003 | − 0.029 [− 0.041; − 0.016] | < 10−4 |
FUNCTIONAL SCALES | ||||||||||||
Physical functioning | − 0.33 [− 1.17; 0.51] | 0.439 | − 0.77 [− 1.68; 0.15] | 0.101 | 0.64 [− 0.38; 1.66] | 0.222 | 0.86 [− 0.12; 1.85] | 0.086 | − 0.66 [− 0.95; − 0.37] | < 10−4 | −0.028 [− 0.036; − 0.020] | < 10−4 |
Role functioning | 0.80 [− 0.38; 1.98] | 0.183 | 0.27 [− 0.93; 1.46] | 0.663 | 1.10 [− 0.27; 2.47] | 0.116 | 1.25 [− 0.08; 2.57] | 0.065 | − 0.57 [− 0.86; − 0.29] | < 10−4 | − 0.018 [− 0.024; − 0.012] | < 10−4 |
Social functioning | 0.11 [− 0.92; 1.15] | 0.831 | − 0.35 [− 1.44; 0.75] | 0.533 | 1.15 [− 0.07; 2.37] | 0.065 | 1.32 [0.09; 2.55] | 0.036 | − 0.57 [− 0.84; − 0.29] | < 10−4 | −0.017 [− 0.022; − 0.012] | < 10−4 |
SYMPTOM SCALES | ||||||||||||
Fatigue | − 1.30 [− 2.35; − 0.24] | 0.016 | −0.78 [− 1.84; 0.28] | 0.148 | −0.51 [− 1.76; 0.74] | 0.422 | − 0.72 [− 1.90; 0.47] | 0.235 | −0.63 [− 0.91; − 0.35] | < 10−4 | 0.019 [0.012; 0.026] | < 10−4 |
Pain | −2.47 [−3.54; − 1.40] | < 10−3 | −1.99 [− 3.01; − 0.98] | < 10−3 | −1.01 [− 2.21; 0.19] | 0.098 | −0.88 [− 2.00; 0.24] | 0.125 | − 0.50 [− 0.77; − 0.22] | < 10−3 | 0.017 [0.007; 0.026] | < 10−3 |