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Table 1 Dose escalation and de-escalation boundaries for the asBOINcomb design, with φ = 0.3, t1 = t2 = 100, Δ1=0.3φ, and Δ2=1.7φ

From: A clinical phase I dose-finding design with adaptive shrinking boundaries for drug combination trials

nj

3

6

9

12

15

18

21

24

27

30

λe

0.179

0.186

0.190

0.194

0.197

0.200

0.203

0.206

0.208

0.211

λd

0.402

0.397

0.394

0.392

0.389

0.387

0.385

0.383

0.381

0.379

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BMC Medical Research Methodology

ISSN: 1471-2288

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