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Table 2 Eight different boundary ranges (∆1 is the initial value of the increasing boundary and ∆2 is the initial value of the decreasing boundary)

From: A clinical phase I dose-finding design with adaptive shrinking boundaries for drug combination trials

 

bp_1_9

bp_2_8

bp_3_7

bp_4_6

bp_5_5

bp_6_4

bp_7_3

bp_8_2

bp_9_1

1

0.1φ

0.2φ

0.3φ

0.4φ

0.5φ

0.6φ

0.7φ

0.8φ

0.9φ

2

1.9φ

1.8φ

1.7φ

1.6φ

1.5φ

1.4φ

1.3φ

1.2φ

1.1φ