Estimating sensitivity and specificity of diagnostic tests using latent class models that account for conditional dependence between tests: a simulation study

Table 1 Models and conditional dependence structures compared

Model	Dependence Structure	Effect Type Used	Included in this paper’s simulation
Model 0	Conditional Independence between all tests	NA	Yes
Model 1	Dependence between IHA and IgM ICT in disease positive individuals	Fixed	No
Model 2	Dependence between IHA and IgG ICT in disease positive individuals	Fixed	No
Model 3	Dependence between all serological tests in disease positive individuals	Random	Yes
Model 4	Dependence between all serological tests in disease negative individuals	Random	Yes
MODEL 5	Dependence between all serological tests in disease positive and disease negative individuals	Random	Yes

Models 0–4 considered in Limmathurotsakul et al. [14]. Model 5 an extension not considered in the previous analyses. The last column highlights the scenarios that are considered in the simulation in this paper

ISSN: 1471-2288