Table 2 Eight scenarios of treatment effects for patients with different biomarker levels
| Â | Biomarker2 | |||||||
|---|---|---|---|---|---|---|---|---|
Level | 1 | 2 | 3 | 4 | 1 | 2 | 3 | 4 |
Biomarker1 | Scenario 1 | Scenario 2 | ||||||
 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
 2 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
 3 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
| Â | Scenario 3 | Scenario 4 | ||||||
 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
 2 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
 3 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 1 |
| Â | Scenario 5 | Scenario 6 | ||||||
 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
 2 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 |
 3 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 |
| Â | Scenario 7 | Scenario 8 | ||||||
 1 | 0 | 0 | 0 | 1 | 0 | 0.25 | 0.5 | 1 |
 2 | 0 | 0 | 1 | 1 | 0.25 | 0.5 | 1 | 1.25 |
 3 | 0 | 1 | 1 | 1 | 0.5 | 1 | 1.25 | 1.5 |