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Table 4 Discordant recommendations justified by paradigmatic situations

From: Strong recommendations from low certainty evidence: a cross-sectional analysis of a suite of national guidelines

Paradigmatic situation

Number of recommendations

N = 57 (%)

Life-threatening (or catastrophical) situation

36 (63.1)

Uncertain benefit, certain harm

14 (24.6)

Potential equivalence, one option clearly less risky or costly

6 (10.5)

High certainty in similar benefits, one option potentially more risky or costly

1 (1.7)

Potential catastrophic harm

0 (0)