Utilization of five data mining algorithms combined with simplified preprocessing to establish reference intervals of thyroid-related hormones for non-elderly adults

Table 1 Reference interval established by different methods

		Reference data set				Test data set
		Transformed parametric method				Hoffmann				Bhattacharya
		LL	90%CI	UL	90%CI	LL	90%CI	UL	90%CI	LL	90%CI	UL	90%CI
TSH (μIU/L)	T	0.801	0.7722–0.8305	4.221	4.0900–4.3570	0.709	0.6930–0.7173	4.976	4.8361–5.0115	0.714	0.7120–0.7154	4.861	4.8380–4.8847
FT3 (pg/mL)	T	2.58	2.558–2.602	3.82	3.787–3.845	2.59	2.578–2.604	3.90	3.888–3.919	2.56	2.553–2.567	3.98	3.965–3.999
	F	2.49	2.457–2.519	3.49	3.464–3.517	2.54	2.536–2.581	3.60	3.596–3.608	2.53	2.530–2.532	3.60	3.595–3.600
	M	2.83	2.805–2.855	3.93	3.895–3.976	2.85	2.841–2.868	3.98	3.975–3.988	2.77	2.765–2.770	4.02	3.983–4.077
FT4 (ng/dL)	T	0.98	0.966–0.984	1.53	1.515–1.543	0.96	0.960–0.966	1.56	1.554–1.563	0.96	0.960–0.961	1.56	1.558–1.562
	F	0.95	0.942–0.966	1.42	1.400–1.430	0.94	0.939–0.945	1.48	1.472–1.480	0.94	0.936–0.940	1.48	1.472–1.480
	M	1.01	1.000–1.028	1.58	1.557–1.594	1.01	1.007–1.013	1.60	1.596–1.604	1.01^a	1.010–1.010	1.60	1.593–1.603
TT3 (ng/mL)	T	0.80	0.790–0.806	1.38	1.362–1.400	0.80	0.800–0.806	1.44	1.430–1.444	0.81	0.798–0.814	1.43	1.417–1.449
TT4 (μg/dL)	T	5.46	5.379–5.539	10.05	9.944–10.158	5.34	5.311–5.379	10.56	10.54–10.60	5.28	5.252–5.335	10.59	10.487–10.683

^aBefore the implementation of the rounding principle, the original result is 1.007(1.006,1.008)

ISSN: 1471-2288