Table 3 Association of clinical variables and ABO haplotypes with VT recurrence in MARTHA (prospective and ambispective) and MEGA
Variables | MARTHA Prospective | MARTHA Ambispective | MEGA | Meta-analysis MARTHA Ambispective & MEGA | ||||
|---|---|---|---|---|---|---|---|---|
N = 839 Nb recurrences = 159 | N = 1,504 Nb recurrences = 565 | N = 1,248 Nb recurrences = 428 | ||||||
HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
Gender | ||||||||
Men | 1.47 (1.03–2.09) | 0.034 | 1.65 (1.36–2.01) | 4.0 × 10–7 | 1.81 (1.46–2.25) | 5.9 × 10–8 | 1.72 (1.47–2.01) | 3.0 × 10–12 |
Age at the first VT (10 years increase) | 0.91 (0.81–1.02) | 0.105 | 1.08 (1.02–1.15) | 0.020 | 0.99 (0.92–1.07) | 0.810 | 1.05 (0.99–1.11) | 0.107 |
Type of the first VT | ||||||||
DVT | 0.85 (0.60–1.21) | 0.368 | 1.17 (0.96–1.42) | 0.140 | 1.15 (0.95–1.40) | 0.160 | 1.16 (1.01–1.33) | 0.036 |
Characteristic of the first VT | ||||||||
Provoked | 0.69 (0.48–1.00) | 0.059 | 0.99 (0.80–1.23) | 0.920 | 0.61 (0.49–0.76) | 6.7 × 10–6 | 0.78 (0.67–0.91) | 1.2 × 10–3 |
ABO haplotypes | ||||||||
A1 | 1.32 (1.02–1.70) | 0.035 | 1.15 (1.00–1.32) | 0.045 | 1.21 (1.03–1.42) | 0.018 | 1.18 (1.05–1.33) | 4.2 × 10–3 |
A2 | 1.13 (0.68–1.88) | 0.644 | 1.27 (0.98–1.64) | 0.061 | 1.11 (0.86–1.43) | 0.409 | 1.19 (1.00–1.42) | 0.062 |
O1 | Reference | Reference | Reference | Reference | ||||
O2 | 1.05 (0.47–2.35) | 0.896 | 1.19 (0.73–1.94) | 0.476 | 0.86 (0.50–1.49) | 0.584 | 1.03 (0.70–1.52) | 0.880 |
B | 1.00 (0.64–1.57) | 0.998 | 1.02 (0.82–1.27) | 0.874 | 1.00 (0.78–1.29) | 0.987 | 1.01 (0.85–1.21) | 0.900 |