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Data analysis, statistics and modelling

This section considers manuscripts that investigate how statistical techniques can impact study results along with manuscripts that propose new statistical methods that have an application in medical research.

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  1. Implicit in the growing interest in patient-centered outcomes research is a growing need for better evidence regarding how responses to a given intervention or treatment may vary across patients, referred to a...

    Authors: Richard J Willke, Zhiyuan Zheng, Prasun Subedi, Rikard Althin and C Daniel Mullins

    Citation: BMC Medical Research Methodology 2012 12:185

    Content type: Review

    Published on:

  2. Multiple imputation is becoming increasingly popular. Theoretical considerations as well as simulation studies have shown that the inclusion of auxiliary variables is generally of benefit.

    Authors: Jochen Hardt, Max Herke and Rainer Leonhart

    Citation: BMC Medical Research Methodology 2012 12:184

    Content type: Research article

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  3. This study aims at analyzing Health related quality of life (HRQoL) data on the French general population between 1995 and 2003 using an Item Response Theory (IRT) model.

    Authors: Jean-Benoit Hardouin, Etienne Audureau, Alain Leplège and Joël Coste

    Citation: BMC Medical Research Methodology 2012 12:182

    Content type: Research article

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  4. Seasonal variation in the occurrence of cardiovascular diseases has been recognized for decades. In particular, incidence rates of hospitalization with atrial fibrillation (AF) and stroke have shown to exhibit...

    Authors: Anette L Christensen, Søren Lundbye-Christensen, Kim Overvad, Lars H Rasmussen and Claus Dethlefsen

    Citation: BMC Medical Research Methodology 2012 12:174

    Content type: Technical advance

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  5. Coronary heart disease is the leading cause of mortality in the world. One of the outcome indicators recently used to measure hospital performance is 30-day mortality after acute myocardial infarction (AMI). T...

    Authors: Chiara Seghieri, Stefano Mimmi, Jacopo Lenzi and Maria Pia Fantini

    Citation: BMC Medical Research Methodology 2012 12:170

    Content type: Research article

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  6. With the current focus on personalized medicine, patient/subject level inference is often of key interest in translational research. As a result, random effects models (REM) are becoming popular for patient le...

    Authors: Mulugeta Gebregziabher, Leonard Egede, Gregory E Gilbert, Kelly Hunt, Paul J Nietert and Patrick Mauldin

    Citation: BMC Medical Research Methodology 2012 12:163

    Content type: Research article

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  7. Structural equation modeling developed as a statistical melding of path analysis and factor analysis that obscured a fundamental tension between a factor preference for multiple indicators and path modeling’s ...

    Authors: Leslie A Hayduk and Levente Littvay

    Citation: BMC Medical Research Methodology 2012 12:159

    Content type: Debate

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  8. Directed acyclic graphs (DAGs) are an effective means of presenting expert-knowledge assumptions when selecting adjustment variables in epidemiology, whereas the change-in-estimate procedure is a common statis...

    Authors: David Evans, Basile Chaix, Thierry Lobbedez, Christian Verger and Antoine Flahault

    Citation: BMC Medical Research Methodology 2012 12:156

    Content type: Research article

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  9. Recently, network meta-analysis of survival data with a multidimensional treatment effect was introduced. With these models the hazard ratio is not assumed to be constant over time, thereby reducing the possib...

    Authors: Jeroen P Jansen and Shannon Cope

    Citation: BMC Medical Research Methodology 2012 12:152

    Content type: Research article

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  10. Network meta-analysis (NMA), a generalization of conventional MA, allows for assessing the relative effectiveness of multiple interventions. Reporting bias is a major threat to the validity of MA and NMA. Nume...

    Authors: Ludovic Trinquart, Gilles Chatellier and Philippe Ravaud

    Citation: BMC Medical Research Methodology 2012 12:150

    Content type: Research article

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  11. Health-related quality of life (HRQL) has become an increasingly important outcome parameter in clinical trials and epidemiological research. HRQL scores are typically bounded at both ends of the scale and oft...

    Authors: Matthias Hunger, Angela Döring and Rolf Holle

    Citation: BMC Medical Research Methodology 2012 12:144

    Content type: Research article

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  12. Genotyping has become more cost-effective and less invasive with the use of buccal cell sampling. However, low or fragmented DNA yields from buccal cells collected using FTA cards often requires additional who...

    Authors: Matthew N Cooper, Nicholas H de Klerk, Kathryn R Greenop, Sarra E Jamieson, Denise Anderson, Frank M van Bockxmeer, Bruce K Armstrong and Elizabeth Milne

    Citation: BMC Medical Research Methodology 2012 12:141

    Content type: Technical advance

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  13. Indirect treatment comparison (ITC) and mixed treatment comparisons (MTC) have been increasingly used in network meta-analyses. This simulation study comprehensively investigated statistical properties and per...

    Authors: Fujian Song, Allan Clark, Max O Bachmann and Jim Maas

    Citation: BMC Medical Research Methodology 2012 12:138

    Content type: Research article

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  14. Blood pressure is considered to be a leading example of a valid surrogate endpoint. The aims of this study were to (i) formally evaluate systolic and diastolic blood pressure reduction as a surrogate endpoint ...

    Authors: Marissa N Lassere, Kent R Johnson, Michal Schiff and David Rees

    Citation: BMC Medical Research Methodology 2012 12:27

    Content type: Research article

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