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Data analysis, statistics and modelling

Section edited by Chiu-Hsieh (Paul) Hsu

This section considers manuscripts that investigate how statistical techniques can impact study results along with manuscripts that propose new statistical methods that have an application in medical research.

Page 3 of 8

  1. Content type: Research article

    The aim of this study was to examine the relationship between mortality and statin adherence using two different approaches to adherence measurement (summary versus repeated-measures).

    Authors: Mhd. Wasem Alsabbagh, Dean Eurich, Lisa M. Lix, Thomas W. Wilson and David F. Blackburn

    Citation: BMC Medical Research Methodology 2017 17:66

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  2. Content type: Research article

    Seeking treatment in formal healthcare for uncomplicated infections is vital to combating disease in low- and middle-income countries (LMICs). Healthcare treatment-seeking behaviour varies within and between c...

    Authors: Victor A. Alegana, Jim Wright, Carla Pezzulo, Andrew J. Tatem and Peter M. Atkinson

    Citation: BMC Medical Research Methodology 2017 17:67

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  3. Content type: Research article

    The area under the ROC curve (AUC) of risk models is known to be influenced by differences in case-mix and effect size of predictors. The impact of heterogeneity in correlation among predictors has however bee...

    Authors: Suman Kundu, Madhu Mazumdar and Bart Ferket

    Citation: BMC Medical Research Methodology 2017 17:63

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  4. Content type: Research article

    The usual kappa statistic requires that all observations be enumerated. However, in free-response assessments, only positive (or abnormal) findings are notified, but negative (or normal) findings are not. This...

    Authors: Marc Carpentier, Christophe Combescure, Laura Merlini and Thomas V. Perneger

    Citation: BMC Medical Research Methodology 2017 17:62

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  5. Content type: Research article

    When developing a prediction model for survival data it is essential to validate its performance in external validation settings using appropriate performance measures. Although a number of such measures have ...

    Authors: M. Shafiqur Rahman, Gareth Ambler, Babak Choodari-Oskooei and Rumana Z. Omar

    Citation: BMC Medical Research Methodology 2017 17:60

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  6. Content type: Research article

    Framingham Stroke Risk Score (FSRS) is the most well-regarded risk appraisal tools for evaluating an individual’s absolute risk on stroke onset. However, several widely accepted risk factors for stroke were no...

    Authors: Xiao-Hua Zhou, Xiaonan Wang, Ashlee Duncan, Guizhou Hu and Jiayin Zheng

    Citation: BMC Medical Research Methodology 2017 17:58

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  7. Content type: Research article

    Evaluations of diagnostic tests are challenging because of the indirect nature of their impact on patient outcomes. Model-based health economic evaluations of tests allow different types of evidence from vario...

    Authors: Bethany Shinkins, Yaling Yang, Lucy Abel and Thomas R. Fanshawe

    Citation: BMC Medical Research Methodology 2017 17:56

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  8. Content type: Research Article

    Screening and detection of cases are a common public health priority for treatable chronic conditions with long subclinical periods. However, the validity of commonly-used metrics from surveillance systems for...

    Authors: Ralph Brinks, Annika Hoyer, Deborah B. Rolka, Oliver Kuss and Edward W. Gregg

    Citation: BMC Medical Research Methodology 2017 17:54

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  9. Content type: Research article

    ROC (receiver operating characteristic) curve analysis is well established for assessing how well a marker is capable of discriminating between individuals who experience disease onset and individuals who do n...

    Authors: Adina Najwa Kamarudin, Trevor Cox and Ruwanthi Kolamunnage-Dona

    Citation: BMC Medical Research Methodology 2017 17:53

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  10. Content type: Research article

    Mediation is an important issue considered in the behavioral, medical, and social sciences. It addresses situations where the effect of a predictor variable X on an outcome variable Y is explained to some extent ...

    Authors: George J. Knafl, Kathleen A. Knafl, Margaret Grey, Jane Dixon, Janet A. Deatrick and Agatha M. Gallo

    Citation: BMC Medical Research Methodology 2017 17:45

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  11. Content type: Research article

    Meta-analysis is very useful to summarize the effect of a treatment or a risk factor for a given disease. Often studies report results based on log-transformed variables in order to achieve the principal assum...

    Authors: Miguel Rodríguez-Barranco, Aurelio Tobías, Daniel Redondo, Elena Molina-Portillo and María José Sánchez

    Citation: BMC Medical Research Methodology 2017 17:44

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    The Erratum to this article has been published in BMC Medical Research Methodology 2017 17:91

  12. Content type: Research article

    Most meta-analyses in systematic reviews, including Cochrane ones, do not have sufficient statistical power to detect or refute even large intervention effects. This is why a meta-analysis ought to be regarded...

    Authors: Jørn Wetterslev, Janus Christian Jakobsen and Christian Gluud

    Citation: BMC Medical Research Methodology 2017 17:39

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  13. Content type: Research article

    The aim was to review the literature to identify the most effective methods for creating a representative sample of refugee and asylum seeker groups living in the community to participate in health and mental ...

    Authors: Joanne C. Enticott, Frances Shawyer, Shiva Vasi, Kimberly Buck, I-Hao Cheng, Grant Russell, Ritsuko Kakuma, Harry Minas and Graham Meadows

    Citation: BMC Medical Research Methodology 2017 17:37

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  14. Content type: Research Article

    When developing risk models for binary data with small or sparse data sets, the standard maximum likelihood estimation (MLE) based logistic regression faces several problems including biased or infinite estima...

    Authors: M. Shafiqur Rahman and Mahbuba Sultana

    Citation: BMC Medical Research Methodology 2017 17:33

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  15. Content type: Research article

    In a new influenza pandemic, travel data such as arrival times of cases seeded by the originating country can be regarded as a combination of the epidemic size and the mobility networks of infections connectin...

    Authors: Ka Chun Chong, Benny Chung Ying Zee and Maggie Haitian Wang

    Citation: BMC Medical Research Methodology 2017 17:31

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  16. Content type: Research article

    In the two-stage randomised trial design, a randomly sampled subset of study participants are permitted to choose their own treatment, while the remaining participants are randomised to treatment in the usual ...

    Authors: Stephen D. Walter, Robin M. Turner, Petra Macaskill, Kirsten J. McCaffery and Les Irwig

    Citation: BMC Medical Research Methodology 2017 17:29

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  17. Content type: Research article

    Individual patient data meta-analyses (IPD-MA) are often performed using a one-stage approach-- a form of generalized linear mixed model (GLMM) for binary outcomes. We compare (i) one-stage to two-stage approa...

    Authors: Doneal Thomas, Robert Platt and Andrea Benedetti

    Citation: BMC Medical Research Methodology 2017 17:28

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  18. Content type: Research article

    Within epidemiological and clinical research, missing data are a common issue and often over looked in publications. When the issue of missing observations is addressed it is usually assumed that the missing d...

    Authors: M. Smuk, J. R. Carpenter and T. P. Morris

    Citation: BMC Medical Research Methodology 2017 17:21

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    The Erratum to this article has been published in BMC Medical Research Methodology 2017 17:51

  19. Content type: Research article

    The analysis of correlated binary data is commonly addressed through the use of conditional models with random effects included in the systematic component as opposed to generalized estimating equations (GEE) ...

    Authors: Jie Pu, Di Fang and Jeffrey R. Wilson

    Citation: BMC Medical Research Methodology 2017 17:20

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  20. Content type: Research article

    The cohort multiple randomised controlled trial (cmRCT) design provides an opportunity to incorporate the benefits of randomisation within clinical practice; thus reducing costs, integrating electronic healthc...

    Authors: Jane Candlish, Alexander Pate, Matthew Sperrin and Tjeerd van Staa

    Citation: BMC Medical Research Methodology 2017 17:17

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    The Erratum to this article has been published in BMC Medical Research Methodology 2017 17:47

  21. Content type: Research article

    The BSI-18 contains the three six-item scales somatization, depression, and anxiety as well as the Global Severity Index (GSI), including all 18 items. The BSI-18 is the latest and shortest of the multidimensi...

    Authors: Gabriele Helga Franke, Susanne Jaeger, Heide Glaesmer, Claus Barkmann, Katja Petrowski and Elmar Braehler

    Citation: BMC Medical Research Methodology 2017 17:14

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  22. Content type: Research Article

    Many questions in statistical genomics can be formulated in terms of variable selection of candidate biological factors for modeling a trait or quantity of interest. Often, in these applications, additional co...

    Authors: Jing Zhai, Chiu-Hsieh Hsu and Z. John Daye

    Citation: BMC Medical Research Methodology 2017 17:12

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  23. Content type: Research Article

    The attributable risk (AR) measures the proportion of disease cases that can be attributed to an exposure in the population. Several definitions and estimation methods have been proposed for survival data.

    Authors: Malamine Gassama, Jacques Bénichou, Laureen Dartois and Anne C. M. Thiébaut

    Citation: BMC Medical Research Methodology 2017 17:10

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  24. Content type: Research Article

    The risk of a disease or psychiatric disorder is frequently measured by the age-specific cumulative incidence. Cumulative incidence estimates are often derived in cohort studies with individuals recruited over...

    Authors: Stefan N. Hansen, Morten Overgaard, Per K. Andersen and Erik T. Parner

    Citation: BMC Medical Research Methodology 2017 17:7

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  25. Content type: Research article

    Many continuous item responses (CIRs) are encountered in healthcare settings, but no one uses item response theory’s (IRT) probabilistic modeling to present graphical presentations for interpreting CIR results...

    Authors: Tsair-Wei Chien, Yang Shao and Shu-Chun Kuo

    Citation: BMC Medical Research Methodology 2017 17:4

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  26. Content type: Research article

    Centralisation of thrombolysis may offer substantial benefits. The aim of this study was to assess short term costs and effects of centralisation of thrombolysis and optimised care in a decentralised system.

    Authors: Maarten M. H. Lahr, Durk-Jouke van der Zee, Gert-Jan Luijckx, Patrick C. A. J. Vroomen and Erik Buskens

    Citation: BMC Medical Research Methodology 2017 17:5

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  27. Content type: Research article

    Multiple imputation is frequently used to deal with missing data in healthcare research. Although it is known that the outcome should be included in the imputation model when imputing missing covariate values,...

    Authors: Evangelos Kontopantelis, Ian R. White, Matthew Sperrin and Iain Buchan

    Citation: BMC Medical Research Methodology 2017 17:2

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  28. Content type: Research article

    Clinical prediction models (CPMs) are increasingly deployed to support healthcare decisions but they are derived inconsistently, in part due to limited data. An emerging alternative is to aggregate existing CP...

    Authors: Glen P. Martin, Mamas A. Mamas, Niels Peek, Iain Buchan and Matthew Sperrin

    Citation: BMC Medical Research Methodology 2017 17:1

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  29. Content type: Research article

    Recent studies of the quality of in-hospital care have used the Quality of Interaction Schedule (QuIS) to rate interactions observed between staff and inpatients in a variety of ward conditions. The QuIS was d...

    Authors: Ines Mesa-Eguiagaray, Dankmar Böhning, Chris McLean, Peter Griffiths, Jackie Bridges and Ruth M Pickering

    Citation: BMC Medical Research Methodology 2016 16:171

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  30. Content type: Research Article

    In an individually randomised controlled trial where the treatment is delivered by a health professional it seems likely that the effectiveness of the treatment, independent of any treatment effect, could depe...

    Authors: Laura Flight, Annabel Allison, Munyaradzi Dimairo, Ellen Lee, Laura Mandefield and Stephen J. Walters

    Citation: BMC Medical Research Methodology 2016 16:165

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  31. Content type: Research Article

    Ten events per variable (EPV) is a widely advocated minimal criterion for sample size considerations in logistic regression analysis. Of three previous simulation studies that examined this minimal EPV criteri...

    Authors: Maarten van Smeden, Joris A. H. de Groot, Karel G. M. Moons, Gary S. Collins, Douglas G. Altman, Marinus J. C. Eijkemans and Johannes B. Reitsma

    Citation: BMC Medical Research Methodology 2016 16:163

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  32. Content type: Research article

    Outcome prediction is important in the clinical decision-making process. Artificial neural networks (ANN) have been used to predict the risk of post-operative events, including survival, and are increasingly b...

    Authors: Ana Lopez-de-Andres, Valentin Hernandez-Barrera, Roberto Lopez, Pablo Martin-Junco, Isabel Jimenez-Trujillo, Alejandro Alvaro-Meca, Miguel Angel Salinero-Fort and Rodrigo Jimenez-Garcia

    Citation: BMC Medical Research Methodology 2016 16:160

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  33. Content type: Research article

    The Behavioral Risk Factor Surveillance System (BRFSS) is a network of health-related telephone surveys--conducted by all 50 states, the District of Columbia, and participating US territories—that receive tech...

    Authors: Ronaldo Iachan, Carol Pierannunzi, Kristie Healey, Kurt J. Greenlund and Machell Town

    Citation: BMC Medical Research Methodology 2016 16:155

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  34. Content type: Research article

    In surveillance networks based on voluntary participation of health-care professionals, there is little choice regarding the selection of participants’ characteristics. External information about participants,...

    Authors: Cécile Souty and Pierre-Yves Boëlle

    Citation: BMC Medical Research Methodology 2016 16:156

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  35. Content type: Research article

    The study of circulating biomarkers and their association with disease outcomes has become progressively complex due to advances in the measurement of these biomarkers through multiplex technologies. The Least...

    Authors: Monica M. Vasquez, Chengcheng Hu, Denise J. Roe, Zhao Chen, Marilyn Halonen and Stefano Guerra

    Citation: BMC Medical Research Methodology 2016 16:154

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  36. Content type: Research article

    Randomization procedure in randomized controlled trials (RCTs) permits an unbiased estimation of causal effects. However, in clinical practice, differential compliance between arms may cause a strong violation...

    Authors: Annalisa Pezzi, Michele Cavo, Annibale Biggeri, Elena Zamagni and Oriana Nanni

    Citation: BMC Medical Research Methodology 2016 16:150

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  37. Content type: Research Article

    A number of potential therapeutic approaches for neurological disorders have failed to provide convincing evidence of efficacy, prompting pharmaceutical and health companies to discontinue their involvement in...

    Authors: Lorenzo G. Tanadini, John D. Steeves, Armin Curt and Torsten Hothorn

    Citation: BMC Medical Research Methodology 2016 16:149

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  38. Content type: Research article

    Typical survival studies follow individuals to an event and measure explanatory variables for that event, sometimes repeatedly over the course of follow up. The Cox regression model has been used widely in the...

    Authors: Julius S. Ngwa, Howard J. Cabral, Debbie M. Cheng, Michael J. Pencina, David R. Gagnon, Michael P. LaValley and L. Adrienne Cupples

    Citation: BMC Medical Research Methodology 2016 16:148

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  39. Content type: Research article

    The GH-2000 score has been developed as a powerful and unique technique for the detection of growth hormone misuse by sportsmen and women. The score depends upon the measurement of two growth hormone (GH) sens...

    Authors: Dankmar Böhning, Walailuck Böhning, Nishan Guha, David A. Cowan, Peter H. Sönksen and Richard I. G. Holt

    Citation: BMC Medical Research Methodology 2016 16:147

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    The Publisher's Erratum to this article has been published in BMC Medical Research Methodology 2016 16:164

  40. Content type: Research Article

    Missing values are a frequent issue in human studies. In many situations, multiple imputation (MI) is an appropriate missing data handling strategy, whereby missing values are imputed multiple times, the analy...

    Authors: Simone Wahl, Anne-Laure Boulesteix, Astrid Zierer, Barbara Thorand and Mark A. van de Wiel

    Citation: BMC Medical Research Methodology 2016 16:144

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    The Erratum to this article has been published in BMC Medical Research Methodology 2016 16:170

  41. Content type: Research article

    Stepped wedge designs have gained recognition as a method for rigorously assessing implementation of evidence-based quality improvement interventions (QIIs) across multiple healthcare sites. In theory, this de...

    Authors: Alexis K. Huynh, Martin L. Lee, Melissa M. Farmer and Lisa V. Rubenstein

    Citation: BMC Medical Research Methodology 2016 16:143

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  42. Content type: Software

    It is widely recognised that the pursuit of sustainable development cannot be accomplished without addressing inequality, or observed differences between subgroups of a population. Monitoring health inequaliti...

    Authors: Ahmad Reza Hosseinpoor, Devaki Nambiar, Anne Schlotheuber, Daniel Reidpath and Zev Ross

    Citation: BMC Medical Research Methodology 2016 16:141

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  43. Content type: Software

    Recently, a growing number of Item-Response Theory (IRT) models has been published, which allow estimation of a common latent variable from data derived by different Patient Reported Outcomes (PROs). When usin...

    Authors: H. Felix Fischer and Matthias Rose

    Citation: BMC Medical Research Methodology 2016 16:142

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  44. Content type: Research article

    Measurement error in self-reported dietary intakes is known to bias the association between dietary intake and a health outcome of interest such as risk of a disease. The association can be distorted further b...

    Authors: George O. Agogo, Hilko van der Voet, Pieter van ’t Veer, Pietro Ferrari, David C. Muller, Emilio Sánchez-Cantalejo, Christina Bamia, Tonje Braaten, Sven Knüppel, Ingegerd Johansson, Fred A. van Eeuwijk and Hendriek C. Boshuizen

    Citation: BMC Medical Research Methodology 2016 16:139

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