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BMC Medical Research Methodology

Data analysis, statistics and modelling

Section edited by Chiu-Hsieh (Paul) Hsu

This section considers manuscripts that investigate how statistical techniques can impact study results along with manuscripts that propose new statistical methods that have an application in medical research.

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  1. Content type: Technical advance

    The sample size required to power a study to a nominal level in a paired comparative diagnostic accuracy study, i.e. studies in which the diagnostic accuracy of two testing procedures is compared relative to a...

    Authors: Gareth P. J. McCray, Andrew C. Titman, Paula Ghaneh and Gillian A. Lancaster

    Citation: BMC Medical Research Methodology 2017 17:102

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  2. Content type: Research article

    Network meta-analysis overcomes the limitations of traditional pair-wise meta-analysis by incorporating all available evidence into a general statistical framework for simultaneous comparisons of several treat...

    Authors: Yu-Kang Tu and Yun-Chun Wu

    Citation: BMC Medical Research Methodology 2017 17:104

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  3. Content type: Research article

    Prognostic models often show poor performance when applied to independent validation data sets. We illustrate how treatment use in a validation set can affect measures of model performance and present the uses...

    Authors: Romin Pajouheshnia, Linda M. Peelen, Karel G. M. Moons, Johannes B. Reitsma and Rolf H. H. Groenwold

    Citation: BMC Medical Research Methodology 2017 17:103

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  4. Content type: Research article

    Complex interventions such as self-management courses are difficult to evaluate due to the many interacting components. The way complex interventions are delivered can influence the effect they have for patien...

    Authors: G. Wojewodka, S. Hurley, S. J. C. Taylor, A. J. Noble, L. Ridsdale and L. H. Goldstein

    Citation: BMC Medical Research Methodology 2017 17:100

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  5. Content type: Research article

    To illustrate the 10-year risks of urinary adverse events (UAEs) among men diagnosed with prostate cancer and treated with different types of therapy, accounting for the competing risk of death.

    Authors: Charlotte A. Bolch, Haitao Chu, Stephanie Jarosek, Stephen R. Cole, Sean Elliott and Beth Virnig

    Citation: BMC Medical Research Methodology 2017 17:93

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  6. Content type: Research Article

    Composite endpoints comprising hospital admissions and death are the primary outcome in many cardiovascular clinical trials. For statistical analysis, a Cox proportional hazards model for the time to first eve...

    Authors: Antje Jahn-Eimermacher, Katharina Ingel, Stella Preussler, Antoni Bayes-Genis and Harald Binder

    Citation: BMC Medical Research Methodology 2017 17:92

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  7. Content type: Research Article

    There are a growing number of observational studies that do not only focus on single biomarkers for predicting an outcome event, but address questions in a multivariable setting. For example, when quantifying ...

    Authors: Andreas Schulz, Daniela Zöller, Stefan Nickels, Manfred E. Beutel, Maria Blettner, Philipp S. Wild and Harald Binder

    Citation: BMC Medical Research Methodology 2017 17:90

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  8. Content type: Research article

    Bayesian hierarchical piecewise regression (BHPR) modeling has not been previously formulated to detect and characterise the mechanism of trajectory divergence between groups of participants that have longitud...

    Authors: Marie-jeanne Buscot, Simon S. Wotherspoon, Costan G. Magnussen, Markus Juonala, Matthew A. Sabin, David P. Burgner, Terho Lehtimäki, Jorma S. A. Viikari, Nina Hutri-Kähönen, Olli T. Raitakari and Russell J. Thomson

    Citation: BMC Medical Research Methodology 2017 17:86

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  9. Content type: Research article

    The nested case-control study (NCC) design within a prospective cohort study is used when outcome data are available for all subjects, but the exposure of interest has not been collected, and is difficult or p...

    Authors: Long H. Ngo, Sharon K. Inouye, Richard N. Jones, Thomas G. Travison, Towia A. Libermann, Simon T. Dillon, George A. Kuchel, Sarinnapha M. Vasunilashorn, David C. Alsop and Edward R. Marcantonio

    Citation: BMC Medical Research Methodology 2017 17:88

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  10. Content type: Research article

    Thanks to the advances in genomics and targeted treatments, more and more prediction models based on biomarkers are being developed to predict potential benefit from treatments in a randomized clinical trial. ...

    Authors: Nils Ternès, Federico Rotolo and Stefan Michiels

    Citation: BMC Medical Research Methodology 2017 17:83

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  11. Content type: Research article

    One potential concern with using mailed surveys containing trauma-related content is the possibility of re-traumatizing survivors without a trained mental health professional present. Prior research provides i...

    Authors: Maureen Murdoch, Shannon Marie Kehle-Forbes and Melissa Ruth Partin

    Citation: BMC Medical Research Methodology 2017 17:81

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  12. Content type: Research Article

    Relative survival analysis is a subfield of survival analysis where competing risks data are observed, but the causes of death are unknown. A first step in the analysis of such data is usually the estimation o...

    Authors: Klemen Pavlič and Maja Pohar Perme

    Citation: BMC Medical Research Methodology 2017 17:79

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  13. Content type: Research article

    Double-adjustment can be used to remove confounding if imbalance exists after propensity score (PS) matching. However, it is not always possible to include all covariates in adjustment. We aimed to find the op...

    Authors: Tri-Long Nguyen, Gary S. Collins, Jessica Spence, Jean-Pierre Daurès, P. J. Devereaux, Paul Landais and Yannick Le Manach

    Citation: BMC Medical Research Methodology 2017 17:78

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  14. Content type: Technical advance

    Health interventions fall along a spectrum from simple to more complex. There is wide interest in methods for reviewing ‘complex interventions’, but few transparent approaches for assessing intervention comple...

    Authors: Simon Lewin, Maggie Hendry, Jackie Chandler, Andrew D. Oxman, Susan Michie, Sasha Shepperd, Barnaby C. Reeves, Peter Tugwell, Karin Hannes, Eva A. Rehfuess, Vivien Welch, Joanne E. Mckenzie, Belinda Burford, Jennifer Petkovic, Laurie M. Anderson, Janet Harris…

    Citation: BMC Medical Research Methodology 2017 17:76

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  15. Content type: Research article

    Achieving adequate response rates is an ongoing challenge for longitudinal studies. The World Trade Center Health Registry is a longitudinal health study that periodically surveys a cohort of ~71,000 people ex...

    Authors: Shengchao Yu, Howard E. Alper, Angela-Maithy Nguyen, Robert M. Brackbill, Lennon Turner, Deborah J. Walker, Carey B. Maslow and Kimberly C. Zweig

    Citation: BMC Medical Research Methodology 2017 17:77

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  16. Content type: Research article

    In studies of recurrent events, it is common to consider a person who has suffered a disease episode and received curative treatment to be not at risk of suffering a new episode for a duration of time. It is a...

    Authors: Yin-Bun Cheung, Ying Xu, Matthew Cairns and Paul Milligan

    Citation: BMC Medical Research Methodology 2017 17:72

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  17. Content type: Research article

    Seeking treatment in formal healthcare for uncomplicated infections is vital to combating disease in low- and middle-income countries (LMICs). Healthcare treatment-seeking behaviour varies within and between c...

    Authors: Victor A. Alegana, Jim Wright, Carla Pezzulo, Andrew J. Tatem and Peter M. Atkinson

    Citation: BMC Medical Research Methodology 2017 17:67

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  18. Content type: Research article

    The scientific evidence-base for policies to tackle health inequalities is limited. Natural policy experiments (NPE) have drawn increasing attention as a means to evaluating the effects of policies on health. ...

    Authors: Yannan Hu, Frank J. van Lenthe, Rasmus Hoffmann, Karen van Hedel and Johan P. Mackenbach

    Citation: BMC Medical Research Methodology 2017 17:68

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