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Data analysis, statistics and modelling

Section edited by Chiu-Hsieh (Paul) Hsu

This section considers manuscripts that investigate how statistical techniques can impact study results along with manuscripts that propose new statistical methods that have an application in medical research.

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  1. Content type: Research Article

    Relative survival analysis is a subfield of survival analysis where competing risks data are observed, but the causes of death are unknown. A first step in the analysis of such data is usually the estimation o...

    Authors: Klemen Pavlič and Maja Pohar Perme

    Citation: BMC Medical Research Methodology 2017 17:79

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  2. Content type: Research article

    Double-adjustment can be used to remove confounding if imbalance exists after propensity score (PS) matching. However, it is not always possible to include all covariates in adjustment. We aimed to find the op...

    Authors: Tri-Long Nguyen, Gary S. Collins, Jessica Spence, Jean-Pierre Daurès, P. J. Devereaux, Paul Landais and Yannick Le Manach

    Citation: BMC Medical Research Methodology 2017 17:78

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  3. Content type: Technical advance

    Health interventions fall along a spectrum from simple to more complex. There is wide interest in methods for reviewing ‘complex interventions’, but few transparent approaches for assessing intervention comple...

    Authors: Simon Lewin, Maggie Hendry, Jackie Chandler, Andrew D. Oxman, Susan Michie, Sasha Shepperd, Barnaby C. Reeves, Peter Tugwell, Karin Hannes, Eva A. Rehfuess, Vivien Welch, Joanne E. Mckenzie, Belinda Burford, Jennifer Petkovic, Laurie M. Anderson, Janet Harris…

    Citation: BMC Medical Research Methodology 2017 17:76

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  4. Content type: Research article

    Achieving adequate response rates is an ongoing challenge for longitudinal studies. The World Trade Center Health Registry is a longitudinal health study that periodically surveys a cohort of ~71,000 people ex...

    Authors: Shengchao Yu, Howard E. Alper, Angela-Maithy Nguyen, Robert M. Brackbill, Lennon Turner, Deborah J. Walker, Carey B. Maslow and Kimberly C. Zweig

    Citation: BMC Medical Research Methodology 2017 17:77

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  5. Content type: Research article

    In studies of recurrent events, it is common to consider a person who has suffered a disease episode and received curative treatment to be not at risk of suffering a new episode for a duration of time. It is a...

    Authors: Yin-Bun Cheung, Ying Xu, Matthew Cairns and Paul Milligan

    Citation: BMC Medical Research Methodology 2017 17:72

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  6. Content type: Research article

    The aim of this study was to examine the relationship between mortality and statin adherence using two different approaches to adherence measurement (summary versus repeated-measures).

    Authors: Mhd. Wasem Alsabbagh, Dean Eurich, Lisa M. Lix, Thomas W. Wilson and David F. Blackburn

    Citation: BMC Medical Research Methodology 2017 17:66

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  7. Content type: Research article

    Seeking treatment in formal healthcare for uncomplicated infections is vital to combating disease in low- and middle-income countries (LMICs). Healthcare treatment-seeking behaviour varies within and between c...

    Authors: Victor A. Alegana, Jim Wright, Carla Pezzulo, Andrew J. Tatem and Peter M. Atkinson

    Citation: BMC Medical Research Methodology 2017 17:67

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  8. Content type: Research article

    The scientific evidence-base for policies to tackle health inequalities is limited. Natural policy experiments (NPE) have drawn increasing attention as a means to evaluating the effects of policies on health. ...

    Authors: Yannan Hu, Frank J. van Lenthe, Rasmus Hoffmann, Karen van Hedel and Johan P. Mackenbach

    Citation: BMC Medical Research Methodology 2017 17:68

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  9. Content type: Research article

    The area under the ROC curve (AUC) of risk models is known to be influenced by differences in case-mix and effect size of predictors. The impact of heterogeneity in correlation among predictors has however bee...

    Authors: Suman Kundu, Madhu Mazumdar and Bart Ferket

    Citation: BMC Medical Research Methodology 2017 17:63

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  10. Content type: Research article

    The usual kappa statistic requires that all observations be enumerated. However, in free-response assessments, only positive (or abnormal) findings are notified, but negative (or normal) findings are not. This...

    Authors: Marc Carpentier, Christophe Combescure, Laura Merlini and Thomas V. Perneger

    Citation: BMC Medical Research Methodology 2017 17:62

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  11. Content type: Research article

    When developing a prediction model for survival data it is essential to validate its performance in external validation settings using appropriate performance measures. Although a number of such measures have ...

    Authors: M. Shafiqur Rahman, Gareth Ambler, Babak Choodari-Oskooei and Rumana Z. Omar

    Citation: BMC Medical Research Methodology 2017 17:60

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  12. Content type: Research article

    Framingham Stroke Risk Score (FSRS) is the most well-regarded risk appraisal tools for evaluating an individual’s absolute risk on stroke onset. However, several widely accepted risk factors for stroke were no...

    Authors: Xiao-Hua Zhou, Xiaonan Wang, Ashlee Duncan, Guizhou Hu and Jiayin Zheng

    Citation: BMC Medical Research Methodology 2017 17:58

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  13. Content type: Research article

    Evaluations of diagnostic tests are challenging because of the indirect nature of their impact on patient outcomes. Model-based health economic evaluations of tests allow different types of evidence from vario...

    Authors: Bethany Shinkins, Yaling Yang, Lucy Abel and Thomas R. Fanshawe

    Citation: BMC Medical Research Methodology 2017 17:56

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  14. Content type: Research Article

    Screening and detection of cases are a common public health priority for treatable chronic conditions with long subclinical periods. However, the validity of commonly-used metrics from surveillance systems for...

    Authors: Ralph Brinks, Annika Hoyer, Deborah B. Rolka, Oliver Kuss and Edward W. Gregg

    Citation: BMC Medical Research Methodology 2017 17:54

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  15. Content type: Research article

    ROC (receiver operating characteristic) curve analysis is well established for assessing how well a marker is capable of discriminating between individuals who experience disease onset and individuals who do n...

    Authors: Adina Najwa Kamarudin, Trevor Cox and Ruwanthi Kolamunnage-Dona

    Citation: BMC Medical Research Methodology 2017 17:53

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  16. Content type: Research article

    Mediation is an important issue considered in the behavioral, medical, and social sciences. It addresses situations where the effect of a predictor variable X on an outcome variable Y is explained to some extent ...

    Authors: George J. Knafl, Kathleen A. Knafl, Margaret Grey, Jane Dixon, Janet A. Deatrick and Agatha M. Gallo

    Citation: BMC Medical Research Methodology 2017 17:45

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