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Data analysis, statistics and modelling

Section edited by Chiu-Hsieh (Paul) Hsu

This section considers manuscripts that investigate how statistical techniques can impact study results along with manuscripts that propose new statistical methods that have an application in medical research.

Page 5 of 9

  1. Content type: Research article

    Multi-Arm Multi-Stage designs aim at comparing several new treatments to a common reference, in order to select or drop any treatment arm to move forward when such evidence already exists based on interim anal...

    Authors: Louis Jacob, Maria Uvarova, Sandrine Boulet, Inva Begaj and Sylvie Chevret

    Citation: BMC Medical Research Methodology 2016 16:67

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  2. Content type: Research Article

    The six-minute walk test (6MWT) is commonly used to quantify exercise capacity in patients with several cardio-pulmonary diseases. Oxygen uptake (

    Authors: Florent Baty, Christian Ritz, Arnoldus van Gestel, Martin Brutsche and Daniel Gerhard

    Citation: BMC Medical Research Methodology 2016 16:66

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  3. Content type: Research Article

    Patient-reported outcome (PRO) measures play a key role in the advancement of patient-centered care research. The accuracy of inferences, relevance of predictions, and the true nature of the associations made ...

    Authors: N. Maritza Dowling, Daniel M. Bolt, Sien Deng and Chenxi Li

    Citation: BMC Medical Research Methodology 2016 16:63

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  4. Content type: Research article

    Recent developments in psychometric modeling and technology allow pooling well-validated items from existing instruments into larger item banks and their deployment through methods of computerized adaptive tes...

    Authors: Jan Stochl, Jan R. Böhnke, Kate E. Pickett and Tim J. Croudace

    Citation: BMC Medical Research Methodology 2016 16:58

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  5. Content type: Research Article

    A 44 % increase was observed in admissions to neonatal intensive care of babies born ≤26 weeks completed gestational age in England between 1995 and 2006. Hospital Episode Statistics (HES) may provide suppleme...

    Authors: Andrei S. Morgan, Neil Marlow, Kate Costeloe and Elizabeth S. Draper

    Citation: BMC Medical Research Methodology 2016 16:57

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  6. Content type: Debate

    Complexity has been linked to health interventions in two ways: first as a property of the intervention, and secondly as a property of the system into which the intervention is implemented. The former recogniz...

    Authors: James Greenwood-Lee, Penelope Hawe, Alberto Nettel-Aguirre, Alan Shiell and Deborah A. Marshall

    Citation: BMC Medical Research Methodology 2016 16:51

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  7. Content type: Research article

    Several indirect comparison methods, including network meta-analyses (NMAs), using individual patient data (IPD) have been developed to synthesize evidence from a network of trials. Although IPD indirect compa...

    Authors: Areti Angeliki Veroniki, Sharon E. Straus, Charlene Soobiah, Meghan J. Elliott and Andrea C. Tricco

    Citation: BMC Medical Research Methodology 2016 16:47

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  8. Content type: Technical advance

    The UK population is ageing; improved understanding of risk factors for hospital admission is required. Linkage of the Hertfordshire Cohort Study (HCS) with Hospital Episode Statistics (HES) data has created a...

    Authors: Leo D. Westbury, Holly E. Syddall, Shirley J. Simmonds, Cyrus Cooper and Avan Aihie Sayer

    Citation: BMC Medical Research Methodology 2016 16:46

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  9. Content type: Research article

    The primary analysis in a longitudinal randomized controlled trial is sometimes a comparison of arms at a single time point. While a two-sample t-test is often used, missing data are common in longitudinal studie...

    Authors: Erin L. Ashbeck and Melanie L. Bell

    Citation: BMC Medical Research Methodology 2016 16:43

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  10. Content type: Research article

    Although covariate adjustment in the analysis of randomised trials can be beneficial, adjustment for continuous covariates is complicated by the fact that the association between covariate and outcome must be ...

    Authors: Brennan C. Kahan, Helen Rushton, Tim P. Morris and Rhian M. Daniel

    Citation: BMC Medical Research Methodology 2016 16:42

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  11. Content type: Research article

    Regression models are widely used to link serial measures of anthropometric size or changes in size to a later outcome. Different parameterisations of these models enable one to target different questions abou...

    Authors: Andrew K. Wills, Bjørn Heine Strand, Kari Glavin, Richard J. Silverwood and Ragnhild Hovengen

    Citation: BMC Medical Research Methodology 2016 16:41

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  12. Content type: Research article

    Regular and timely monitoring of blood glucose (BG) levels in hospitalized patients with diabetes mellitus is crucial to optimizing inpatient glycaemic control. However, methods to quantify timeliness as a mea...

    Authors: Ying Chen, Shih Ling Kao, E-Shyong Tai, Hwee Lin Wee, Eric Yin Hao Khoo, Yilin Ning, Mark Kevin Salloway, Xiaodong Deng and Chuen Seng Tan

    Citation: BMC Medical Research Methodology 2016 16:40

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  13. Content type: Research Article

    Observational post-marketing assessment studies often involve evaluating the effect of a rare treatment on a time-to-event outcome, through the estimation of a marginal hazard ratio. Propensity score (PS) meth...

    Authors: David Hajage, Florence Tubach, Philippe Gabriel Steg, Deepak L. Bhatt and Yann De Rycke

    Citation: BMC Medical Research Methodology 2016 16:38

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  14. Content type: Technical advance

    Although some nonparametric methods have been proposed in the literature to test for the equality of median survival times for censored data in medical research, in general they have inflated type I error rate...

    Authors: Zhongxue Chen and Guoyi Zhang

    Citation: BMC Medical Research Methodology 2016 16:33

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  15. Content type: Research Article

    Clustering commonly affects the uncertainty of parameter estimates in epidemiological studies. Cluster-robust variance estimates (CRVE) are used to construct confidence intervals that account for single-level ...

    Authors: Christian Bottomley, Matthew J. Kirby, Steve W. Lindsay and Neal Alexander

    Citation: BMC Medical Research Methodology 2016 16:29

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  16. Content type: Research article

    The understanding of changes in temporal processes related to human carcinogenesis is limited. One approach for prospective functional genomic studies is to compile trajectories of differential expression of g...

    Authors: Eiliv Lund, Lars Holden, Hege Bøvelstad, Sandra Plancade, Nicolle Mode, Clara-Cecilie Günther, Gregory Nuel, Jean-Christophe Thalabard and Marit Holden

    Citation: BMC Medical Research Methodology 2016 16:28

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  17. Content type: Research article

    A wide-ranging debate has taken place in recent years on mediation analysis and causal modelling, raising profound theoretical, philosophical and methodological questions. The authors build on the results of t...

    Authors: Jonathan Pratschke, Trutz Haase, Harry Comber, Linda Sharp, Marianna de Camargo Cancela and Howard Johnson

    Citation: BMC Medical Research Methodology 2016 16:27

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  18. Content type: Research article

    This paper explores the importance of electronic medical records (EMR) for predicting 30-day all-cause non-elective readmission risk of patients and presents a comparison of prediction performance of commonly ...

    Authors: Liping Tong, Cole Erdmann, Marina Daldalian, Jing Li and Tina Esposito

    Citation: BMC Medical Research Methodology 2016 16:26

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  19. Content type: Research Article

    As gait speed and transfer times are considered to be an important measure of functional ability in older adults, several systems are currently being researched to measure this parameter in the home environmen...

    Authors: Greet Baldewijns, Stijn Luca, Bart Vanrumste and Tom Croonenborghs

    Citation: BMC Medical Research Methodology 2016 16:23

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  20. Content type: Research article

    Comparative performance of the traditional propensity score (PS) and high-dimensional propensity score (hdPS) methods in the adjustment for confounding by indication remains unclear. We aimed to identify which...

    Authors: Jason R. Guertin, Elham Rahme, Colin R. Dormuth and Jacques LeLorier

    Citation: BMC Medical Research Methodology 2016 16:22

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  21. Content type: Research Article

    Most randomized controlled trials with a time-to-event outcome are designed assuming proportional hazards (PH) of the treatment effect. The sample size calculation is based on a logrank test. However, non-prop...

    Authors: Patrick Royston and Mahesh K.B. Parmar

    Citation: BMC Medical Research Methodology 2016 16:16

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  22. Content type: Research Article

    Despite randomization, baseline imbalance and confounding bias may occur in cluster randomized trials (CRTs). Covariate imbalance may jeopardize the validity of statistical inferences if they occur on prognost...

    Authors: Clémence Leyrat, Agnès Caille, Yohann Foucher and Bruno Giraudeau

    Citation: BMC Medical Research Methodology 2016 16:9

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  23. Content type: Research article

    Mortality statistics are used to compare health status of populations; optimally, they base on individual death certificates. However, determining cause of death is error-prone. E.g. cardiovascular disease (CV...

    Authors: Andreas Deckert

    Citation: BMC Medical Research Methodology 2016 16:8

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  24. Content type: Research Article

    As a part of a larger Health Technology Assessment (HTA), the measurement error of a device used to monitor the hemoglobin concentration of a patient undergoing surgery, as well as its decision consequences, w...

    Authors: Emmanuel Charpentier, Vincent Looten, Björn Fahlgren, Alexandre Barna and Loïc Guillevin

    Citation: BMC Medical Research Methodology 2016 16:7

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  25. Content type: TECHNICAL ADVANCE

    In many studies, some information might not be available for the whole cohort, some covariates, or even the outcome, might be ascertained in selected subsamples. These studies are part of a broad category term...

    Authors: Paola Rebora, Laura Antolini, David V. Glidden and Maria Grazia Valsecchi

    Citation: BMC Medical Research Methodology 2016 16:5

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  26. Content type: Research article

    Traditional analyses of standard case-control studies using logistic regression do not allow estimation of time-varying associations between exposures and the outcome. We present two approaches which allow thi...

    Authors: Ruth H. Keogh, Punam Mangtani, Laura Rodrigues and Patrick Nguipdop Djomo

    Citation: BMC Medical Research Methodology 2016 16:2

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  27. Content type: Research article

    Although follicle stimulating hormone (FSH) is known to be predictive of age at final menstrual period (FMP), previous methods use FSH levels measured at time points that are defined relative to the age at FMP...

    Authors: Bei Jiang, Mary D. Sammel, Ellen W. Freeman and Naisyin Wang

    Citation: BMC Medical Research Methodology 2015 15:106

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  28. Content type: Research Article

    Random-effects meta-analysis is commonly performed by first deriving an estimate of the between-study variation, the heterogeneity, and subsequently using this as the basis for combining results, i.e., for estima...

    Authors: Christian Röver, Guido Knapp and Tim Friede

    Citation: BMC Medical Research Methodology 2015 15:99

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  29. Content type: Research Article

    Estimation of incidence of the state of undiagnosed chronic disease provides a crucial missing link for the monitoring of chronic disease epidemics and determining the degree to which changes in prevalence are...

    Authors: Ralph Brinks, Barbara H. Bardenheier, Annika Hoyer, Ji Lin, Sandra Landwehr and Edward W. Gregg

    Citation: BMC Medical Research Methodology 2015 15:98

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  30. Content type: Research article

    Comparing the relative utility of diagnostic tests is challenging when available datasets are small, partial or incomplete. The analytical leverage associated with a large sample size can be gained by integrat...

    Authors: Vivienne Breen, Nikola Kasabov, Ashish M. Kamat, Elsie Jacobson, James M. Suttie, Paul J. O’Sullivan, Laimonis Kavalieris and David G. Darling

    Citation: BMC Medical Research Methodology 2015 15:45

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  31. Content type: Research Article

    When summary results from studies of counts of events in time contain zeros, the study-specific incidence rate ratio (IRR) and its standard error cannot be calculated because the log of zero is undefined. This...

    Authors: Matthew J Spittal, Jane Pirkis and Lyle C Gurrin

    Citation: BMC Medical Research Methodology 2015 15:42

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  32. Content type: Research article

    Cancer incidence and prevalence estimates are necessary to inform health policy, to predict public health impact and to identify etiological factors. Registers have been used to estimate the number of cancer c...

    Authors: Laurent Bailly, Jean Pierre Daurès, Brigitte Dunais and Christian Pradier

    Citation: BMC Medical Research Methodology 2015 15:39

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  33. Content type: Research article

    Small number of clusters and large variation of cluster sizes commonly exist in cluster-randomized trials (CRTs) and are often the critical factors affecting the validity and efficiency of statistical analyses. F

    Authors: Peng Li and David T Redden

    Citation: BMC Medical Research Methodology 2015 15:38

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  34. Content type: Research article

    In many medical studies the likelihood ratio test (LRT) has been widely applied to examine whether the random effects variance component is zero within the mixed effects models framework; whereas little work a...

    Authors: Ping Zeng, Yang Zhao, Hongliang Li, Ting Wang and Feng Chen

    Citation: BMC Medical Research Methodology 2015 15:37

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  35. Content type: Research article

    Network meta-analysis (NMA) is a methodology for indirectly comparing, and strengthening direct comparisons of two or more treatments for the management of disease by combining evidence from multiple studies. ...

    Authors: Howard HZ Thom, Gorana Capkun, Annamaria Cerulli, Richard M Nixon and Luke S Howard

    Citation: BMC Medical Research Methodology 2015 15:34

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  36. Content type: Research article

    In resource-limited settings, monitoring and evaluation (M&E) of antiretroviral treatment (ART) programs often relies on aggregated facility-level data. Such data are limited, however, because of the potential...

    Authors: Sebastien Haneuse, Bethany Hedt-Gauthier, Frank Chimbwandira, Simon Makombe, Lyson Tenthani and Andreas Jahn

    Citation: BMC Medical Research Methodology 2015 15:31

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  37. Content type: Research article

    Sample size calculations should correspond to the intended method of analysis. Nevertheless, for non-normal distributions, they are often done on the basis of normal approximations, even when the data are to b...

    Authors: Bonnie Cundill and Neal DE Alexander

    Citation: BMC Medical Research Methodology 2015 15:28

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  38. Content type: Research Article

    Cancer relapses may be useful to predict the risk of death. To take into account relapse information, the Landmark approach is popular. As an alternative, we propose the joint frailty model for a recurrent eve...

    Authors: Audrey Mauguen, Bernard Rachet, Simone Mathoulin-Pélissier, Gill M Lawrence, Sabine Siesling, Gaëtan MacGrogan, Alexandre Laurent and Virginie Rondeau

    Citation: BMC Medical Research Methodology 2015 15:27

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  39. Content type: Research article

    Cut-point finding is a crucial step for clinical decision making when dealing with diagnostic (or prognostic) biomarkers. The extension of ROC-based cut-point finding methods to the case of censored failure ti...

    Authors: Matteo Rota, Laura Antolini and Maria Grazia Valsecchi

    Citation: BMC Medical Research Methodology 2015 15:24

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  40. Content type: Research article

    Exploring causal associations in HIV research requires careful consideration of numerous epidemiologic limitations. First, a primary cause of HIV, unprotected anal intercourse (UAI), is time-varying and, if it...

    Authors: Adam S Vaughan, Colleen F Kelley, Nicole Luisi, Carlos del Rio, Patrick S Sullivan and Eli S Rosenberg

    Citation: BMC Medical Research Methodology 2015 15:25

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  41. Content type: Research article

    Pediatric traumatic brain injury (TBI) constitutes a significant burden and diagnostic challenge in the emergency department (ED). While large North American research networks have derived clinical prediction ...

    Authors: Shu-Ling Chong, Nan Liu, Sylvaine Barbier and Marcus Eng Hock Ong

    Citation: BMC Medical Research Methodology 2015 15:22

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