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BMC Medical Research Methodology

Data analysis, statistics and modelling

Section edited by Chiu-Hsieh (Paul) Hsu

This section considers manuscripts that investigate how statistical techniques can impact study results along with manuscripts that propose new statistical methods that have an application in medical research.

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  1. Content type: Research article

    The cohort multiple randomised controlled trial (cmRCT) design provides an opportunity to incorporate the benefits of randomisation within clinical practice; thus reducing costs, integrating electronic healthc...

    Authors: Jane Candlish, Alexander Pate, Matthew Sperrin and Tjeerd van Staa

    Citation: BMC Medical Research Methodology 2017 17:17

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    The Erratum to this article has been published in BMC Medical Research Methodology 2017 17:47

  2. Content type: Research article

    The BSI-18 contains the three six-item scales somatization, depression, and anxiety as well as the Global Severity Index (GSI), including all 18 items. The BSI-18 is the latest and shortest of the multidimensi...

    Authors: Gabriele Helga Franke, Susanne Jaeger, Heide Glaesmer, Claus Barkmann, Katja Petrowski and Elmar Braehler

    Citation: BMC Medical Research Methodology 2017 17:14

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  3. Content type: Research Article

    Many questions in statistical genomics can be formulated in terms of variable selection of candidate biological factors for modeling a trait or quantity of interest. Often, in these applications, additional co...

    Authors: Jing Zhai, Chiu-Hsieh Hsu and Z. John Daye

    Citation: BMC Medical Research Methodology 2017 17:12

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  4. Content type: Research Article

    The attributable risk (AR) measures the proportion of disease cases that can be attributed to an exposure in the population. Several definitions and estimation methods have been proposed for survival data.

    Authors: Malamine Gassama, Jacques Bénichou, Laureen Dartois and Anne C. M. Thiébaut

    Citation: BMC Medical Research Methodology 2017 17:10

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  5. Content type: Research Article

    The risk of a disease or psychiatric disorder is frequently measured by the age-specific cumulative incidence. Cumulative incidence estimates are often derived in cohort studies with individuals recruited over...

    Authors: Stefan N. Hansen, Morten Overgaard, Per K. Andersen and Erik T. Parner

    Citation: BMC Medical Research Methodology 2017 17:7

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  6. Content type: Research article

    Many continuous item responses (CIRs) are encountered in healthcare settings, but no one uses item response theory’s (IRT) probabilistic modeling to present graphical presentations for interpreting CIR results...

    Authors: Tsair-Wei Chien, Yang Shao and Shu-Chun Kuo

    Citation: BMC Medical Research Methodology 2017 17:4

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  7. Content type: Research article

    Centralisation of thrombolysis may offer substantial benefits. The aim of this study was to assess short term costs and effects of centralisation of thrombolysis and optimised care in a decentralised system.

    Authors: Maarten M. H. Lahr, Durk-Jouke van der Zee, Gert-Jan Luijckx, Patrick C. A. J. Vroomen and Erik Buskens

    Citation: BMC Medical Research Methodology 2017 17:5

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  8. Content type: Research article

    Multiple imputation is frequently used to deal with missing data in healthcare research. Although it is known that the outcome should be included in the imputation model when imputing missing covariate values,...

    Authors: Evangelos Kontopantelis, Ian R. White, Matthew Sperrin and Iain Buchan

    Citation: BMC Medical Research Methodology 2017 17:2

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  9. Content type: Research article

    Clinical prediction models (CPMs) are increasingly deployed to support healthcare decisions but they are derived inconsistently, in part due to limited data. An emerging alternative is to aggregate existing CP...

    Authors: Glen P. Martin, Mamas A. Mamas, Niels Peek, Iain Buchan and Matthew Sperrin

    Citation: BMC Medical Research Methodology 2017 17:1

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  10. Content type: Research article

    Recent studies of the quality of in-hospital care have used the Quality of Interaction Schedule (QuIS) to rate interactions observed between staff and inpatients in a variety of ward conditions. The QuIS was d...

    Authors: Ines Mesa-Eguiagaray, Dankmar Böhning, Chris McLean, Peter Griffiths, Jackie Bridges and Ruth M Pickering

    Citation: BMC Medical Research Methodology 2016 16:171

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  11. Content type: Research Article

    In an individually randomised controlled trial where the treatment is delivered by a health professional it seems likely that the effectiveness of the treatment, independent of any treatment effect, could depe...

    Authors: Laura Flight, Annabel Allison, Munyaradzi Dimairo, Ellen Lee, Laura Mandefield and Stephen J. Walters

    Citation: BMC Medical Research Methodology 2016 16:165

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  12. Content type: Research Article

    Ten events per variable (EPV) is a widely advocated minimal criterion for sample size considerations in logistic regression analysis. Of three previous simulation studies that examined this minimal EPV criteri...

    Authors: Maarten van Smeden, Joris A. H. de Groot, Karel G. M. Moons, Gary S. Collins, Douglas G. Altman, Marinus J. C. Eijkemans and Johannes B. Reitsma

    Citation: BMC Medical Research Methodology 2016 16:163

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  13. Content type: Research article

    Outcome prediction is important in the clinical decision-making process. Artificial neural networks (ANN) have been used to predict the risk of post-operative events, including survival, and are increasingly b...

    Authors: Ana Lopez-de-Andres, Valentin Hernandez-Barrera, Roberto Lopez, Pablo Martin-Junco, Isabel Jimenez-Trujillo, Alejandro Alvaro-Meca, Miguel Angel Salinero-Fort and Rodrigo Jimenez-Garcia

    Citation: BMC Medical Research Methodology 2016 16:160

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  14. Content type: Research article

    The Behavioral Risk Factor Surveillance System (BRFSS) is a network of health-related telephone surveys--conducted by all 50 states, the District of Columbia, and participating US territories—that receive tech...

    Authors: Ronaldo Iachan, Carol Pierannunzi, Kristie Healey, Kurt J. Greenlund and Machell Town

    Citation: BMC Medical Research Methodology 2016 16:155

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  15. Content type: Research article

    In surveillance networks based on voluntary participation of health-care professionals, there is little choice regarding the selection of participants’ characteristics. External information about participants,...

    Authors: Cécile Souty and Pierre-Yves Boëlle

    Citation: BMC Medical Research Methodology 2016 16:156

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  16. Content type: Research article

    The study of circulating biomarkers and their association with disease outcomes has become progressively complex due to advances in the measurement of these biomarkers through multiplex technologies. The Least...

    Authors: Monica M. Vasquez, Chengcheng Hu, Denise J. Roe, Zhao Chen, Marilyn Halonen and Stefano Guerra

    Citation: BMC Medical Research Methodology 2016 16:154

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