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Data analysis, statistics and modelling

Section edited by Chiu-Hsieh (Paul) Hsu

This section considers manuscripts that investigate how statistical techniques can impact study results along with manuscripts that propose new statistical methods that have an application in medical research.

Page 5 of 19
  1. Content type: Research article

    Meta-analysis is very useful to summarize the effect of a treatment or a risk factor for a given disease. Often studies report results based on log-transformed variables in order to achieve the principal assum...

    Authors: Miguel Rodríguez-Barranco, Aurelio Tobías, Daniel Redondo, Elena Molina-Portillo and María José Sánchez

    Citation: BMC Medical Research Methodology 2017 17:44

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    The Erratum to this article has been published in BMC Medical Research Methodology 2017 17:91

  2. Content type: Research article

    Most meta-analyses in systematic reviews, including Cochrane ones, do not have sufficient statistical power to detect or refute even large intervention effects. This is why a meta-analysis ought to be regarded...

    Authors: Jørn Wetterslev, Janus Christian Jakobsen and Christian Gluud

    Citation: BMC Medical Research Methodology 2017 17:39

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  3. Content type: Research article

    The aim was to review the literature to identify the most effective methods for creating a representative sample of refugee and asylum seeker groups living in the community to participate in health and mental ...

    Authors: Joanne C. Enticott, Frances Shawyer, Shiva Vasi, Kimberly Buck, I-Hao Cheng, Grant Russell, Ritsuko Kakuma, Harry Minas and Graham Meadows

    Citation: BMC Medical Research Methodology 2017 17:37

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  4. Content type: Research Article

    When developing risk models for binary data with small or sparse data sets, the standard maximum likelihood estimation (MLE) based logistic regression faces several problems including biased or infinite estima...

    Authors: M. Shafiqur Rahman and Mahbuba Sultana

    Citation: BMC Medical Research Methodology 2017 17:33

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  5. Content type: Research article

    In a new influenza pandemic, travel data such as arrival times of cases seeded by the originating country can be regarded as a combination of the epidemic size and the mobility networks of infections connectin...

    Authors: Ka Chun Chong, Benny Chung Ying Zee and Maggie Haitian Wang

    Citation: BMC Medical Research Methodology 2017 17:31

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  6. Content type: Research article

    In the two-stage randomised trial design, a randomly sampled subset of study participants are permitted to choose their own treatment, while the remaining participants are randomised to treatment in the usual ...

    Authors: Stephen D. Walter, Robin M. Turner, Petra Macaskill, Kirsten J. McCaffery and Les Irwig

    Citation: BMC Medical Research Methodology 2017 17:29

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  7. Content type: Research article

    Individual patient data meta-analyses (IPD-MA) are often performed using a one-stage approach-- a form of generalized linear mixed model (GLMM) for binary outcomes. We compare (i) one-stage to two-stage approa...

    Authors: Doneal Thomas, Robert Platt and Andrea Benedetti

    Citation: BMC Medical Research Methodology 2017 17:28

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  8. Content type: Research article

    Within epidemiological and clinical research, missing data are a common issue and often over looked in publications. When the issue of missing observations is addressed it is usually assumed that the missing d...

    Authors: M. Smuk, J. R. Carpenter and T. P. Morris

    Citation: BMC Medical Research Methodology 2017 17:21

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    The Erratum to this article has been published in BMC Medical Research Methodology 2017 17:51

  9. Content type: Research article

    The analysis of correlated binary data is commonly addressed through the use of conditional models with random effects included in the systematic component as opposed to generalized estimating equations (GEE) ...

    Authors: Jie Pu, Di Fang and Jeffrey R. Wilson

    Citation: BMC Medical Research Methodology 2017 17:20

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  10. Content type: Research article

    The cohort multiple randomised controlled trial (cmRCT) design provides an opportunity to incorporate the benefits of randomisation within clinical practice; thus reducing costs, integrating electronic healthc...

    Authors: Jane Candlish, Alexander Pate, Matthew Sperrin and Tjeerd van Staa

    Citation: BMC Medical Research Methodology 2017 17:17

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    The Erratum to this article has been published in BMC Medical Research Methodology 2017 17:47

  11. Content type: Research article

    The BSI-18 contains the three six-item scales somatization, depression, and anxiety as well as the Global Severity Index (GSI), including all 18 items. The BSI-18 is the latest and shortest of the multidimensi...

    Authors: Gabriele Helga Franke, Susanne Jaeger, Heide Glaesmer, Claus Barkmann, Katja Petrowski and Elmar Braehler

    Citation: BMC Medical Research Methodology 2017 17:14

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  12. Content type: Research Article

    Many questions in statistical genomics can be formulated in terms of variable selection of candidate biological factors for modeling a trait or quantity of interest. Often, in these applications, additional co...

    Authors: Jing Zhai, Chiu-Hsieh Hsu and Z. John Daye

    Citation: BMC Medical Research Methodology 2017 17:12

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  13. Content type: Research Article

    The attributable risk (AR) measures the proportion of disease cases that can be attributed to an exposure in the population. Several definitions and estimation methods have been proposed for survival data.

    Authors: Malamine Gassama, Jacques Bénichou, Laureen Dartois and Anne C. M. Thiébaut

    Citation: BMC Medical Research Methodology 2017 17:10

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  14. Content type: Research Article

    The risk of a disease or psychiatric disorder is frequently measured by the age-specific cumulative incidence. Cumulative incidence estimates are often derived in cohort studies with individuals recruited over...

    Authors: Stefan N. Hansen, Morten Overgaard, Per K. Andersen and Erik T. Parner

    Citation: BMC Medical Research Methodology 2017 17:7

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  15. Content type: Research article

    Many continuous item responses (CIRs) are encountered in healthcare settings, but no one uses item response theory’s (IRT) probabilistic modeling to present graphical presentations for interpreting CIR results...

    Authors: Tsair-Wei Chien, Yang Shao and Shu-Chun Kuo

    Citation: BMC Medical Research Methodology 2017 17:4

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  16. Content type: Research article

    Centralisation of thrombolysis may offer substantial benefits. The aim of this study was to assess short term costs and effects of centralisation of thrombolysis and optimised care in a decentralised system.

    Authors: Maarten M. H. Lahr, Durk-Jouke van der Zee, Gert-Jan Luijckx, Patrick C. A. J. Vroomen and Erik Buskens

    Citation: BMC Medical Research Methodology 2017 17:5

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  17. Content type: Research article

    Multiple imputation is frequently used to deal with missing data in healthcare research. Although it is known that the outcome should be included in the imputation model when imputing missing covariate values,...

    Authors: Evangelos Kontopantelis, Ian R. White, Matthew Sperrin and Iain Buchan

    Citation: BMC Medical Research Methodology 2017 17:2

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