Study design

Section edited by Timothy Beebe

This section considers manuscripts that investigate how choices of research methodology and study design can impact study results, including research participation and study outcomes.

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  1. Research article

    Systematic review of statistical approaches to quantify, or correct for, measurement error in a continuous exposure in nutritional epidemiology

    Several statistical approaches have been proposed to assess and correct for exposure measurement error. We aimed to provide a critical overview of the most common approaches used in nutritional epidemiology.

    Derrick A. Bennett, Denise Landry, Julian Little and Cosetta Minelli

    BMC Medical Research Methodology 2017 17:146

    Published on: 19 September 2017

  2. Research article

    Pragmatic clinical trials embedded in healthcare systems: generalizable lessons from the NIH Collaboratory

    The clinical research enterprise is not producing the evidence decision makers arguably need in a timely and cost effective manner; research currently involves the use of labor-intensive parallel systems that ...

    Kevin P. Weinfurt, Adrian F. Hernandez, Gloria D. Coronado, Lynn L. DeBar, Laura M. Dember, Beverly B. Green, Patrick J. Heagerty, Susan S. Huang, Kathryn T. James, Jeffrey G. Jarvik, Eric B. Larson, Vincent Mor, Richard Platt, Gary E. Rosenthal, Edward J. Septimus, Gregory E. Simon…

    BMC Medical Research Methodology 2017 17:144

    Published on: 18 September 2017

  3. Correspondence

    Conducting a team-based multi-sited focused ethnography in primary care

    Focused ethnography is an applied and pragmatic form of ethnography that explores a specific social phenomenon as it occurs in everyday life. Based on the literature a problem-focused research question is form...

    A.P. Bikker, H. Atherton, H. Brant, T. Porqueddu, J.L. Campbell, A. Gibson, B. McKinstry, C. Salisbury and S. Ziebland

    BMC Medical Research Methodology 2017 17:139

    Published on: 12 September 2017

  4. Research article

    Factors associated with attrition in a longitudinal online study: results from the HaBIDS panel

    Knowing about predictors of attrition in a panel is important to initiate early measures against loss of participants. We investigated attrition in both early and late phase of an online panel with special foc...

    Nicole Rübsamen, Manas K. Akmatov, Stefanie Castell, André Karch and Rafael T. Mikolajczyk

    BMC Medical Research Methodology 2017 17:132

    Published on: 31 August 2017

  5. Research article

    The impact of the lookback period and definition of confirmatory events on the identification of incident cancer cases in administrative data

    This cohort study examined the impact of the lengths of lookback and confirmation periods as well as the definition of confirmatory events on the number of incident cancer cases identified and age-standardized...

    Jonas Czwikla, Kathrin Jobski and Tania Schink

    BMC Medical Research Methodology 2017 17:122

    Published on: 14 August 2017

  6. Research Article

    Implementing the EffTox dose-finding design in the Matchpoint trial

    The Matchpoint trial aims to identify the optimal dose of ponatinib to give with conventional chemotherapy consisting of fludarabine, cytarabine and idarubicin to chronic myeloid leukaemia patients in blastic ...

    Kristian Brock, Lucinda Billingham, Mhairi Copland, Shamyla Siddique, Mirjana Sirovica and Christina Yap

    BMC Medical Research Methodology 2017 17:112

    Published on: 20 July 2017

  7. Research article

    Cost and yield considerations when expanding recruitment for genetic studies: the primary open-angle African American glaucoma genetics study

    African Americans have been historically under-represented in genetic studies. More research is needed on effective recruitment strategies for this population, especially on approaches that supplement traditio...

    Rebecca Salowe, Laura O’Keefe, Sayaka Merriam, Roy Lee, Naira Khachatryan, Prithvi Sankar, Eydie Miller-Ellis, Amanda Lehman, Victoria Addis, Windell Murphy, Jeffrey Henderer, Maureen Maguire and Joan O’Brien

    BMC Medical Research Methodology 2017 17:101

    Published on: 14 July 2017

  8. Research article

    Selection bias and subject refusal in a cluster-randomized controlled trial

    Selection bias and non-participation bias are major methodological concerns which impact external validity. Cluster-randomized controlled trials are especially prone to selection bias as it is impractical to b...

    Rochelle Yang, Barry L. Carter, Tyler H. Gums, Brian M. Gryzlak, Yinghui Xu and Barcey T. Levy

    BMC Medical Research Methodology 2017 17:94

    Published on: 10 July 2017

  9. Research article

    Overview of systematic reviews of therapeutic ranges: methodologies and recommendations for practice

    Many medicines are dosed to achieve a particular therapeutic range, and monitored using therapeutic drug monitoring (TDM). The evidence base for a therapeutic range can be evaluated using systematic reviews, t...

    Lewis Cooney, Yoon K. Loke, Su Golder, Jamie Kirkham, Andrea Jorgensen, Ian Sinha and Daniel Hawcutt

    BMC Medical Research Methodology 2017 17:84

    Published on: 2 June 2017

  10. Research article

    An experimental comparison of web-push vs. paper-only survey procedures for conducting an in-depth health survey of military spouses

    Previous research has found that a “web-push” approach to data collection, which involves contacting people by mail to request an Internet survey response while withholding a paper response option until later ...

    Hope Seib McMaster, Cynthia A. LeardMann, Steven Speigle and Don A. Dillman

    BMC Medical Research Methodology 2017 17:73

    Published on: 26 April 2017

  11. Research article

    Sample size and power determination when limited preliminary information is available

    We describe a novel strategy for power and sample size determination developed for studies utilizing investigational technologies with limited available preliminary data, specifically of imaging biomarkers. We...

    Christine E. McLaren, Wen-Pin Chen, Thomas D. O’Sullivan, Daniel L. Gillen, Min-Ying Su, Jeon H. Chen and Bruce J. Tromberg

    BMC Medical Research Methodology 2017 17:75

    Published on: 26 April 2017

  12. Study protocol

    Protocol for the development of a salutogenic intrapartum core outcome set (SIPCOS)

    Maternity intrapartum care research and clinical care more often focus on outcomes that minimise or prevent adverse health rather than on what constitutes positive health and wellbeing (salutogenesis). This wa...

    Valerie Smith, Deirdre Daly, Ingela Lundgren, Tine Eri, Cecily Begley, Mechthild M. Gross, Soo Downe, Zarko Alfirevic and Declan Devane

    BMC Medical Research Methodology 2017 17:61

    Published on: 19 April 2017

  13. Correspondence

    Practical partnered research to improve weight loss among overweight/obese veterans: lessons from the trenches

    Obesity and obesity-related conditions, such as type 2 diabetes, are a major issue for Veteran health. Veterans Health Administration (VA) researchers and health systems leaders have worked separately and toge...

    Mona AuYoung, Laura J. Damschroder, Linda Kinsinger, Tannaz Moin and Caroline R. Richardson

    BMC Medical Research Methodology 2017 17:50

    Published on: 29 March 2017

  14. Research article

    The effect of postal questionnaire burden on response rate and answer patterns following admission to intensive care: a randomised controlled trial

    The effects of postal questionnaire burden on return rates and answers given are unclear following treatment on an intensive care unit (ICU). We aimed to establish the effects of different postal questionnaire...

    Robert Hatch, Duncan Young, Vicki Barber, David A Harrison and Peter Watkinson

    BMC Medical Research Methodology 2017 17:49

    Published on: 27 March 2017

  15. Research article

    The feasibility of matching on a propensity score for acupuncture in a prospective cohort study of patients with chronic pain

    Propensity scores are typically applied in retrospective cohort studies. We describe the feasibility of matching on a propensity score derived from a retrospective cohort and subsequently applied in a prospect...

    Eric S. Johnson, John F. Dickerson, William M. Vollmer, Alee M. Rowley, Cheryl Ritenbaugh, Richard A. Deyo and Lynn DeBar

    BMC Medical Research Methodology 2017 17:42

    Published on: 16 March 2017

  16. Research article

    Why sample selection matters in exploratory factor analysis: implications for the 12-item World Health Organization Disability Assessment Schedule 2.0

    Sample selection can substantially affect the solutions generated using exploratory factor analysis. Validation studies of the 12-item World Health Organization (WHO) Disability Assessment Schedule 2.0 (WHODAS...

    Cadeyrn J. Gaskin, Sylvie D. Lambert, Steven J. Bowe and Liliana Orellana

    BMC Medical Research Methodology 2017 17:40

    Published on: 11 March 2017

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