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Study design

Section edited by Demosthenes Panagiotakos

This section considers manuscripts that investigate how choices of research methodology and study design can impact study results, including research participation and study outcomes.

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  1. Content type: Research article

    Knowing about predictors of attrition in a panel is important to initiate early measures against loss of participants. We investigated attrition in both early and late phase of an online panel with special foc...

    Authors: Nicole Rübsamen, Manas K. Akmatov, Stefanie Castell, André Karch and Rafael T. Mikolajczyk

    Citation: BMC Medical Research Methodology 2017 17:132

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  2. Content type: Research article

    The Barthel Index (BI) is a measure of independence in activities of daily living (ADL). In the modified Barthel Index (MBI), a five-point system replaced the original two or three or four point rating system....

    Authors: Tomoko Ohura, Kimitaka Hase, Yoshie Nakajima and Takeo Nakayama

    Citation: BMC Medical Research Methodology 2017 17:131

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  3. Content type: Research article

    This cohort study examined the impact of the lengths of lookback and confirmation periods as well as the definition of confirmatory events on the number of incident cancer cases identified and age-standardized...

    Authors: Jonas Czwikla, Kathrin Jobski and Tania Schink

    Citation: BMC Medical Research Methodology 2017 17:122

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  4. Content type: Research article

    Each year over five million people develop chronic non-malignant pain and can experience healthcare as an adversarial struggle. The aims of this study were: (1) to bring together qualitative evidence syntheses...

    Authors: Fran Toye, Kate Seers, Erin Hannink and Karen Barker

    Citation: BMC Medical Research Methodology 2017 17:116

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  5. Content type: Research Article

    The Matchpoint trial aims to identify the optimal dose of ponatinib to give with conventional chemotherapy consisting of fludarabine, cytarabine and idarubicin to chronic myeloid leukaemia patients in blastic ...

    Authors: Kristian Brock, Lucinda Billingham, Mhairi Copland, Shamyla Siddique, Mirjana Sirovica and Christina Yap

    Citation: BMC Medical Research Methodology 2017 17:112

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  6. Content type: Research article

    African Americans have been historically under-represented in genetic studies. More research is needed on effective recruitment strategies for this population, especially on approaches that supplement traditio...

    Authors: Rebecca Salowe, Laura O’Keefe, Sayaka Merriam, Roy Lee, Naira Khachatryan, Prithvi Sankar, Eydie Miller-Ellis, Amanda Lehman, Victoria Addis, Windell Murphy, Jeffrey Henderer, Maureen Maguire and Joan O’Brien

    Citation: BMC Medical Research Methodology 2017 17:101

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  7. Content type: Research article

    Selection bias and non-participation bias are major methodological concerns which impact external validity. Cluster-randomized controlled trials are especially prone to selection bias as it is impractical to b...

    Authors: Rochelle Yang, Barry L. Carter, Tyler H. Gums, Brian M. Gryzlak, Yinghui Xu and Barcey T. Levy

    Citation: BMC Medical Research Methodology 2017 17:94

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  8. Content type: Research article

    Many medicines are dosed to achieve a particular therapeutic range, and monitored using therapeutic drug monitoring (TDM). The evidence base for a therapeutic range can be evaluated using systematic reviews, t...

    Authors: Lewis Cooney, Yoon K. Loke, Su Golder, Jamie Kirkham, Andrea Jorgensen, Ian Sinha and Daniel Hawcutt

    Citation: BMC Medical Research Methodology 2017 17:84

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  9. Content type: Research article

    Previous research has found that a “web-push” approach to data collection, which involves contacting people by mail to request an Internet survey response while withholding a paper response option until later ...

    Authors: Hope Seib McMaster, Cynthia A. LeardMann, Steven Speigle and Don A. Dillman

    Citation: BMC Medical Research Methodology 2017 17:73

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  10. Content type: Research article

    We describe a novel strategy for power and sample size determination developed for studies utilizing investigational technologies with limited available preliminary data, specifically of imaging biomarkers. We...

    Authors: Christine E. McLaren, Wen-Pin Chen, Thomas D. O’Sullivan, Daniel L. Gillen, Min-Ying Su, Jeon H. Chen and Bruce J. Tromberg

    Citation: BMC Medical Research Methodology 2017 17:75

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  11. Content type: Research article

    Evaluation of the potential effectiveness of a programme’s objectives (health or otherwise) is important in demonstrating how programmes work. However, evaluations are expensive and can focus on unrealistic ou...

    Authors: Melissa Belford, Tony Robertson and Ruth Jepson

    Citation: BMC Medical Research Methodology 2017 17:70

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  12. Content type: Study protocol

    Maternity intrapartum care research and clinical care more often focus on outcomes that minimise or prevent adverse health rather than on what constitutes positive health and wellbeing (salutogenesis). This wa...

    Authors: Valerie Smith, Deirdre Daly, Ingela Lundgren, Tine Eri, Cecily Begley, Mechthild M. Gross, Soo Downe, Zarko Alfirevic and Declan Devane

    Citation: BMC Medical Research Methodology 2017 17:61

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  13. Content type: Correspondence

    Obesity and obesity-related conditions, such as type 2 diabetes, are a major issue for Veteran health. Veterans Health Administration (VA) researchers and health systems leaders have worked separately and toge...

    Authors: Mona AuYoung, Laura J. Damschroder, Linda Kinsinger, Tannaz Moin and Caroline R. Richardson

    Citation: BMC Medical Research Methodology 2017 17:50

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  14. Content type: Research article

    The effects of postal questionnaire burden on return rates and answers given are unclear following treatment on an intensive care unit (ICU). We aimed to establish the effects of different postal questionnaire...

    Authors: Robert Hatch, Duncan Young, Vicki Barber, David A Harrison and Peter Watkinson

    Citation: BMC Medical Research Methodology 2017 17:49

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  15. Content type: Research article

    Propensity scores are typically applied in retrospective cohort studies. We describe the feasibility of matching on a propensity score derived from a retrospective cohort and subsequently applied in a prospect...

    Authors: Eric S. Johnson, John F. Dickerson, William M. Vollmer, Alee M. Rowley, Cheryl Ritenbaugh, Richard A. Deyo and Lynn DeBar

    Citation: BMC Medical Research Methodology 2017 17:42

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  16. Content type: Research article

    Sample selection can substantially affect the solutions generated using exploratory factor analysis. Validation studies of the 12-item World Health Organization (WHO) Disability Assessment Schedule 2.0 (WHODAS...

    Authors: Cadeyrn J. Gaskin, Sylvie D. Lambert, Steven J. Bowe and Liliana Orellana

    Citation: BMC Medical Research Methodology 2017 17:40

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  17. Content type: Research Article

    Information and theory beyond copula concepts are essential to understand the dependence relationship between several marginal covariates distributions. In a therapeutic trial data scheme, most of the time, ce...

    Authors: Charles Fontaine, Jean-Pierre Daurès and Paul Landais

    Citation: BMC Medical Research Methodology 2017 17:27

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  18. Content type: Research article

    Observational studies are widely used in pharmacoepidemiology. Several designs can be used, in particular self-controlled designs (case-crossover and self-controlled case series). These designs offer the advan...

    Authors: Nathalie Gault, Johann Castañeda-Sanabria, Yann De Rycke, Sylvie Guillo, Stéphanie Foulon and Florence Tubach

    Citation: BMC Medical Research Methodology 2017 17:25

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  19. Content type: Research article

    Multiple barriers may inhibit the adoption of clinical interventions and impede successful implementation. Use of standardised methods to prioritise barriers to target when selecting implementation interventio...

    Authors: Louise E. Craig, Leonid Churilov, Liudmyla Olenko, Dominique A. Cadilhac, Rohan Grimley, Simeon Dale, Cintia Martinez-Garduno, Elizabeth McInnes, Julie Considine, Jeremy M. Grimshaw and Sandy Middleton

    Citation: BMC Medical Research Methodology 2017 17:24

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