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BMC Medical Research Methodology

Study design

Section edited by Timothy Beebe

This section considers manuscripts that investigate how choices of research methodology and study design can impact study results, including research participation and study outcomes.

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  1. Content type: Research article

    The self-controlled case series (SCCS) is a useful design for investigating associations between outcomes and transient exposures. The SCCS design controls for all fixed covariates, but effect modification can...

    Authors: Steven Hawken, Beth K. Potter, Julian Little, Eric I. Benchimol, Salah Mahmud, Robin Ducharme and Kumanan Wilson

    Citation: BMC Medical Research Methodology 2016 16:126

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  2. Content type: Research article

    There are a variety of methods for priority setting in health research but few studies have addressed how to prioritise the gaps that exist between research evidence and clinical practice. This study aimed to ...

    Authors: Nicole M. Rankin, Deborah McGregor, Phyllis N. Butow, Kate White, Jane L. Phillips, Jane M. Young, Sallie A. Pearson, Sarah York and Tim Shaw

    Citation: BMC Medical Research Methodology 2016 16:110

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  3. Content type: Debate

    Evidence syntheses, and in particular systematic reviews (SRs), have become one of the cornerstones of evidence-based health care. The Assessment of Multiple Systematic Reviews (AMSTAR) tool has become the mos...

    Authors: Uta Wegewitz, Beate Weikert, Alba Fishta, Anja Jacobs and Dawid Pieper

    Citation: BMC Medical Research Methodology 2016 16:111

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  4. Content type: Research article

    The Cohort Multiple Randomised Controlled Trial (cmRCT) is a newly proposed pragmatic trial design; recently several cmRCT have been initiated. This study tests the unresolved question of whether differential ...

    Authors: Alexander Pate, Jane Candlish, Matthew Sperrin and Tjeerd Pieter Van Staa

    Citation: BMC Medical Research Methodology 2016 16:109

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  5. Content type: Research article

    Our aim is to conduct an exploratory study to provide an in-depth characterization of a neighborhood’s social and physical environment in relation to cardiovascular health. A mixed-methods approach was used to...

    Authors: Usama Bilal, Julia Díez, Silvia Alfayate, Pedro Gullón, Isabel del Cura, Francisco Escobar, María Sandín and Manuel Franco

    Citation: BMC Medical Research Methodology 2016 16:104

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  6. Content type: Research article

    In observational studies, matched case-control designs are routinely conducted to improve study precision. How to select covariates for match or adjustment, however, is still a great challenge for estimating c...

    Authors: Hongkai Li, Zhongshang Yuan, Ping Su, Tingting Wang, Yuanyuan Yu, Xiaoru Sun and Fuzhong Xue

    Citation: BMC Medical Research Methodology 2016 16:102

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  7. Content type: Correspondence

    Community-based research has gained increasing recognition in health research over the last two decades. Such participatory research approaches are lauded for their ability to anchor research in lived experien...

    Authors: Mona Loutfy, Saara Greene, V. Logan Kennedy, Johanna Lewis, Jamie Thomas-Pavanel, Tracey Conway, Alexandra de Pokomandy, Nadia O’Brien, Allison Carter, Wangari Tharao, Valerie Nicholson, Kerrigan Beaver, Danièle Dubuc, Jacqueline Gahagan, Karène Proulx-Boucher, Robert S. Hogg…

    Citation: BMC Medical Research Methodology 2016 16:101

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  8. Content type: Research article

    There is currently no guidance for selecting a specific difference to be detected in a superiority trial. We explored 3 factors that in our opinion should influence the difference to be detected (type of outco...

    Authors: Angèle Gayet-Ageron, Anne-Sophie Jannot, Thomas Agoritsas, Sandrine Rudaz, Christophe Combescure and Thomas Perneger

    Citation: BMC Medical Research Methodology 2016 16:89

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  9. Content type: Study protocol

    Placebo effects are mediated by expectancy, which is highly influenced by psychosocial factors of a treatment context. These factors are difficult to standardize. Furthermore, dedicated placebo research often ...

    Authors: Bjoern Horing, Nathan D. Newsome, Paul Enck, Sabarish V. Babu and Eric R. Muth

    Citation: BMC Medical Research Methodology 2016 16:84

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  10. Content type: Research article

    A systematic review on the use of incentives to promote questionnaire return in clinical trials suggest they are effective, but not all studies have sufficient funds to use them. Promising an incentive once da...

    Authors: Pollyanna Hardy, Jennifer L. Bell and Peter Brocklehurst

    Citation: BMC Medical Research Methodology 2016 16:82

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  11. Content type: Research article

    Action research (AR) and randomized controlled trials (RCTs) are usually considered to be theoretically and practically incompatible. However, we argue that their respective strengths and weaknesses can be com...

    Authors: Karen Day, Timothy W. Kenealy and Nicolette F. Sheridan

    Citation: BMC Medical Research Methodology 2016 16:70

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  12. Content type: Research article

    Given the worldwide proliferation of cellphones, this paper examines their potential use for the surveillance of non-communicable disease (NCD) risk factors in a Middle Eastern country.

    Authors: Abla M. Sibai, Lilian A. Ghandour, Rawan Chaaban and Ali H. Mokdad

    Citation: BMC Medical Research Methodology 2016 16:64

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  13. Content type: Research article

    The Drug-Taking Confidence Questionnaire evaluates a drug user’s confidence in his or her ability to resist the urge to consume psychoactive substances in high-risk situations. This study’s objective was to de...

    Authors: Selene Cordeiro Vasconcelos, Everton Botelho Sougey, Iracema da Silva Frazão, Nigel Ernest Turner, Vânia Pinheiro Ramos and Murilo Duarte da Costa Lima

    Citation: BMC Medical Research Methodology 2016 16:55

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  14. Content type: Research article

    This study aimed to characterise the factors relating to participation in a postal follow-up study in Aboriginal and non-Aboriginal individuals, given the need to quantify potential biases from loss to follow-...

    Authors: Lina Gubhaju, Emily Banks, Rona Macniven, Grace Joshy, Bridgette J. McNamara, Adrian Bauman and Sandra J. Eades

    Citation: BMC Medical Research Methodology 2016 16:53

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  15. Content type: Technical advance

    An increasing number of qualitative evidence syntheses papers are found in health care literature. Many of these syntheses use a strictly exhaustive search strategy to collect articles, mirroring the standard ...

    Authors: Charlotte Benoot, Karin Hannes and Johan Bilsen

    Citation: BMC Medical Research Methodology 2016 16:21

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  16. Content type: Research article

    It is well recognized that treatment effects may not be homogeneous across the study population. Subgroup analyses constitute a fundamental step in the assessment of evidence from confirmatory (Phase III) clin...

    Authors: Julien Tanniou, Ingeborg van der Tweel, Steven Teerenstra and Kit C. B. Roes

    Citation: BMC Medical Research Methodology 2016 16:20

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  17. Content type: Research article

    Inefficient experimental designs are common in animal-based biomedical research, wasting resources and potentially leading to unreplicable results. Here we illustrate the intrinsic statistical power of split-p...

    Authors: Michael Walker, Carole Fureix, Rupert Palme, Jonathan A. Newman, Jamie Ahloy Dallaire and Georgia Mason

    Citation: BMC Medical Research Methodology 2016 16:11

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  18. Content type: Research article

    With the increase of clinical trial costs during the last decades, the design of feasibility studies has become an essential process to reduce avoidable and costly protocol amendments. This design includes tim...

    Authors: Iñaki Soto-Rey, Benjamin Trinczek, Yannick Girardeau, Eric Zapletal, Nadir Ammour, Justin Doods, Martin Dugas and Fleur Fritz

    Citation: BMC Medical Research Methodology 2015 15:44

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