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Study design

Section edited by Demosthenes Panagiotakos

This section considers manuscripts that investigate how choices of research methodology and study design can impact study results, including research participation and study outcomes.

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  1. Content type: Research article

    Connected individuals (or nodes) in a network are more likely to be similar than two randomly selected nodes due to homophily and/or network influence. Distinguishing between these two influences is an importa...

    Authors: Kori Sauser Zachrison, Theodore J. Iwashyna, Achamyeleh Gebremariam, Meghan Hutchins and Joyce M Lee

    Citation: BMC Medical Research Methodology 2016 16:174

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  2. Content type: Research article

    This paper describes the methodological developments of the sexual health items included in the Health Behaviour in School-aged Children (HBSC) study since their mandatory inclusion in the study in 2002. The c...

    Authors: Honor Young, András Költő, Marta Reis, Elizabeth M. Saewyc, Nathalie Moreau, Lorraine Burke, Alina Cosma, Béat Windlin, Saoirse Nic Gabhainn and Emmanuelle Godeau

    Citation: BMC Medical Research Methodology 2016 16:169

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  3. Content type: Research article

    Conventional randomized placebo-controlled study design assumes the absence of drug*placebo interaction. We hypothesized the presence of such an interaction and that conventionally estimated drug effect might ...

    Authors: Muhammad M. Hammami, Safa Hammami, Reem Al-Swayeh, Eman Al-Gaai, Faduma Abdi Farah and Sophia J. S. De Padua

    Citation: BMC Medical Research Methodology 2016 16:166

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  4. Content type: Research article

    As biobanks play an increasing role in the genomic research that will lead to precision medicine, input from diverse and large populations of patients in a variety of health care settings will be important in ...

    Authors: Maureen E. Smith, Saskia C. Sanderson, Kyle B. Brothers, Melanie F. Myers, Jennifer McCormick, Sharon Aufox, Martha J. Shrubsole, Nanibaá A. Garrison, Nathaniel D. Mercaldo, Jonathan S. Schildcrout, Ellen Wright Clayton, Armand H. Matheny Antommaria, Melissa Basford, Murray Brilliant, John J. Connolly, Stephanie M. Fullerton…

    Citation: BMC Medical Research Methodology 2016 16:162

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  5. Content type: Research article

    Variation in development methods of Pressure Ulcer Risk Assessment Instruments has led to inconsistent inclusion of risk factors and concerns about content validity. A new evidenced-based Risk Assessment Instr...

    Authors: S. Coleman, J. Nixon, J. Keen, D. Muir, L. Wilson, E. McGinnis, N. Stubbs, C. Dealey and E. A. Nelson

    Citation: BMC Medical Research Methodology 2016 16:158

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  6. Content type: Research article

    Effective community-partnered and patient-centered outcomes research needs to address community priorities. However, optimal sampling methods to engage stakeholders from hard-to-reach, vulnerable communities t...

    Authors: Melissa A. Valerio, Natalia Rodriguez, Paula Winkler, Jaime Lopez, Meagen Dennison, Yuanyuan Liang and Barbara J. Turner

    Citation: BMC Medical Research Methodology 2016 16:146

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  7. Content type: Study protocol

    Hydroxyurea (HU) has been demonstrated to be efficacious in reducing complications in individuals with sickle cell anemia (SCA) but poor adherence is a barrier. Directly Observed Therapy (DOT) has been shown t...

    Authors: Abel Makubi, Philip Sasi, Mariam Ngaeje, Enrico M. Novelli, Bruno P. Mmbando, Mark T. Gladwin and Julie Makani

    Citation: BMC Medical Research Methodology 2016 16:140

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  8. Content type: Research article

    Sepsis and severe sepsis are common conditions in hospital settings, and are associated with high rates of morbidity and mortality, but reported incidences vary considerably. In this literature review, we desc...

    Authors: Saga Elise Mariansdatter, Andreas Halgreen Eiset, Kirstine Kobberøe Søgaard and Christian Fynbo Christiansen

    Citation: BMC Medical Research Methodology 2016 16:137

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  9. Content type: Research article

    Selective allocation of patients into the compared groups of a randomised trial may cause allocation bias, but the mechanisms behind the bias and its directionality are incompletely understood. We therefore an...

    Authors: Asger Paludan-Müller, David Ruben Teindl Laursen and Asbjørn Hróbjartsson

    Citation: BMC Medical Research Methodology 2016 16:133

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  10. Content type: Research article

    The self-controlled case series (SCCS) is a useful design for investigating associations between outcomes and transient exposures. The SCCS design controls for all fixed covariates, but effect modification can...

    Authors: Steven Hawken, Beth K. Potter, Julian Little, Eric I. Benchimol, Salah Mahmud, Robin Ducharme and Kumanan Wilson

    Citation: BMC Medical Research Methodology 2016 16:126

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  11. Content type: Research article

    There are a variety of methods for priority setting in health research but few studies have addressed how to prioritise the gaps that exist between research evidence and clinical practice. This study aimed to ...

    Authors: Nicole M. Rankin, Deborah McGregor, Phyllis N. Butow, Kate White, Jane L. Phillips, Jane M. Young, Sallie A. Pearson, Sarah York and Tim Shaw

    Citation: BMC Medical Research Methodology 2016 16:110

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  12. Content type: Debate

    Evidence syntheses, and in particular systematic reviews (SRs), have become one of the cornerstones of evidence-based health care. The Assessment of Multiple Systematic Reviews (AMSTAR) tool has become the mos...

    Authors: Uta Wegewitz, Beate Weikert, Alba Fishta, Anja Jacobs and Dawid Pieper

    Citation: BMC Medical Research Methodology 2016 16:111

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  13. Content type: Research article

    The Cohort Multiple Randomised Controlled Trial (cmRCT) is a newly proposed pragmatic trial design; recently several cmRCT have been initiated. This study tests the unresolved question of whether differential ...

    Authors: Alexander Pate, Jane Candlish, Matthew Sperrin and Tjeerd Pieter Van Staa

    Citation: BMC Medical Research Methodology 2016 16:109

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  14. Content type: Research article

    Our aim is to conduct an exploratory study to provide an in-depth characterization of a neighborhood’s social and physical environment in relation to cardiovascular health. A mixed-methods approach was used to...

    Authors: Usama Bilal, Julia Díez, Silvia Alfayate, Pedro Gullón, Isabel del Cura, Francisco Escobar, María Sandín and Manuel Franco

    Citation: BMC Medical Research Methodology 2016 16:104

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  15. Content type: Research article

    In observational studies, matched case-control designs are routinely conducted to improve study precision. How to select covariates for match or adjustment, however, is still a great challenge for estimating c...

    Authors: Hongkai Li, Zhongshang Yuan, Ping Su, Tingting Wang, Yuanyuan Yu, Xiaoru Sun and Fuzhong Xue

    Citation: BMC Medical Research Methodology 2016 16:102

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  16. Content type: Correspondence

    Community-based research has gained increasing recognition in health research over the last two decades. Such participatory research approaches are lauded for their ability to anchor research in lived experien...

    Authors: Mona Loutfy, Saara Greene, V. Logan Kennedy, Johanna Lewis, Jamie Thomas-Pavanel, Tracey Conway, Alexandra de Pokomandy, Nadia O’Brien, Allison Carter, Wangari Tharao, Valerie Nicholson, Kerrigan Beaver, Danièle Dubuc, Jacqueline Gahagan, Karène Proulx-Boucher, Robert S. Hogg…

    Citation: BMC Medical Research Methodology 2016 16:101

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  17. Content type: Research article

    There is currently no guidance for selecting a specific difference to be detected in a superiority trial. We explored 3 factors that in our opinion should influence the difference to be detected (type of outco...

    Authors: Angèle Gayet-Ageron, Anne-Sophie Jannot, Thomas Agoritsas, Sandrine Rudaz, Christophe Combescure and Thomas Perneger

    Citation: BMC Medical Research Methodology 2016 16:89

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  18. Content type: Study protocol

    Placebo effects are mediated by expectancy, which is highly influenced by psychosocial factors of a treatment context. These factors are difficult to standardize. Furthermore, dedicated placebo research often ...

    Authors: Bjoern Horing, Nathan D. Newsome, Paul Enck, Sabarish V. Babu and Eric R. Muth

    Citation: BMC Medical Research Methodology 2016 16:84

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