Skip to content


BMC Medical Research Methodology

Study design

Section edited by Demosthenes Panagiotakos

This section considers manuscripts that investigate how choices of research methodology and study design can impact study results, including research participation and study outcomes.

Previous Page Page 4 of 8 Next Page
  1. Content type: Technical advance

    An increasing number of qualitative evidence syntheses papers are found in health care literature. Many of these syntheses use a strictly exhaustive search strategy to collect articles, mirroring the standard ...

    Authors: Charlotte Benoot, Karin Hannes and Johan Bilsen

    Citation: BMC Medical Research Methodology 2016 16:21

    Published on:

  2. Content type: Research article

    It is well recognized that treatment effects may not be homogeneous across the study population. Subgroup analyses constitute a fundamental step in the assessment of evidence from confirmatory (Phase III) clin...

    Authors: Julien Tanniou, Ingeborg van der Tweel, Steven Teerenstra and Kit C. B. Roes

    Citation: BMC Medical Research Methodology 2016 16:20

    Published on:

  3. Content type: Research article

    Inefficient experimental designs are common in animal-based biomedical research, wasting resources and potentially leading to unreplicable results. Here we illustrate the intrinsic statistical power of split-p...

    Authors: Michael Walker, Carole Fureix, Rupert Palme, Jonathan A. Newman, Jamie Ahloy Dallaire and Georgia Mason

    Citation: BMC Medical Research Methodology 2016 16:11

    Published on:

  4. Content type: Research article

    With the increase of clinical trial costs during the last decades, the design of feasibility studies has become an essential process to reduce avoidable and costly protocol amendments. This design includes tim...

    Authors: Iñaki Soto-Rey, Benjamin Trinczek, Yannick Girardeau, Eric Zapletal, Nadir Ammour, Justin Doods, Martin Dugas and Fleur Fritz

    Citation: BMC Medical Research Methodology 2015 15:44

    Published on:

  5. Content type: Research article

    Informed consent is the foundation of the ethical conduct of health research. Obtaining informed consent may unwittingly interfere with the data collected in research studies, particularly if they concern sens...

    Authors: Lambert Felix, Patrick Keating and Jim McCambridge

    Citation: BMC Medical Research Methodology 2015 15:41

    Published on:

  6. Content type: Research article

    Survey research in healthcare is an important tool to collect information about healthcare delivery, service use and overall issues relating to quality of care. Unfortunately, physicians are often a group with...

    Authors: Ceara Tess Cunningham, Hude Quan, Brenda Hemmelgarn, Tom Noseworthy, Cynthia A Beck, Elijah Dixon, Susan Samuel, William A Ghali, Lindsay L Sykes and Nathalie Jetté

    Citation: BMC Medical Research Methodology 2015 15:32

    Published on:

  7. Content type: Research article

    Low participation rates reduce effective sample size, statistical power and can increase risk for selection bias. Previous research suggests that offering choice of participation mode can improve participation...

    Authors: Naomi Heijmans, Jan van Lieshout and Michel Wensing

    Citation: BMC Medical Research Methodology 2015 15:29

    Published on:

  8. Content type: Research article

    Effective strategies for contacting and recruiting study participants are critical in conducting clinical research. In this study, we conducted two sequential randomized controlled trials of mail- and telephon...

    Authors: Victor D Dinglas, Minxuan Huang, Kristin A Sepulveda, Mariela Pinedo, Ramona O Hopkins, Elizabeth Colantuoni and Dale M Needham

    Citation: BMC Medical Research Methodology 2015 15:5

    Published on:

  9. Content type: Research article

    General Practitioners (GPs) respond poorly to postal surveys. Consequently there is potential for reduced data quality and bias in the findings. In general population surveys, response to postal questionnaires...

    Authors: Elizabeth Cottrell, Edward Roddy, Trishna Rathod, Elaine Thomas, Mark Porcheret and Nadine E Foster

    Citation: BMC Medical Research Methodology 2015 15:3

    Published on:

  10. Content type: Research article

    Controlling bias is key to successful randomized controlled trials for behaviour change. Bias can be generated at multiple points during a study, for example, when participants are allocated to different group...

    Authors: Philippe J Giabbanelli and Rik Crutzen

    Citation: BMC Medical Research Methodology 2014 14:130

    Published on:

  11. Content type: Research article

    Focus groups are commonly used to explore participants’ experiences in health and social care research. Although it is suggested that having demographically homogenous groups may help put participants at ease,...

    Authors: Nan Greenwood, Theresa Ellmers and Jess Holley

    Citation: BMC Medical Research Methodology 2014 14:107

    Published on:

  12. Content type: Research article

    Paper questionnaires are a common means to collect self-reported information in population-based epidemiological studies. Over the past decades, the response rates to epidemiological studies have been decreasi...

    Authors: Elisa Flüß, Christine M Bond, Gareth T Jones and Gary J Macfarlane

    Citation: BMC Medical Research Methodology 2014 14:104

    Published on:

  13. Content type: Technical advance

    In 2012 mobile phone numbers were included into the ongoing New South Wales Population Health Survey (NSWPHS) using an overlapping dual-frame design. Previously in the NSWPHS the sample was selected using rand...

    Authors: Margo L Barr, Raymond A Ferguson, Phil J Hughes and David G Steel

    Citation: BMC Medical Research Methodology 2014 14:102

    Published on:

  14. Content type: Research article

    Randomised controlled trials may be of limited use to evaluate the multidisciplinary and multimodal interventions required to effectively treat complex patients in routine clinical practice; pragmatic action r...

    Authors: Jack J Bell, Tony Rossi, Judith D Bauer and Sandra Capra

    Citation: BMC Medical Research Methodology 2014 14:98

    Published on:

  15. Content type: Research article

    Insight into local health service provision in rural communities is limited in the literature. The dominant workforce focus in the rural health literature, while revealing issues of shortage of maldistribution...

    Authors: Robyn Adams, Anne Jones, Sophie Lefmann and Lorraine Sheppard

    Citation: BMC Medical Research Methodology 2014 14:94

    Published on:

  16. Content type: Research article

    Estimates of prevalence are known to be affected by the design of cross-sectional studies. A pan-European study provided an opportunity to compare the effect of two cross-sectional study designs on estimates o...

    Authors: Georgi Nellis, Irja Lutsar, Heili Varendi, Karolin Toompere, Mark A Turner, Jennifer Duncan and Tuuli Metsvaht

    Citation: BMC Medical Research Methodology 2014 14:89

    Published on:

  17. Content type: Correspondence

    This article attempts to define terminology and to describe a process for writing adaptive, early phase study protocols which are transparent, self-intuitive and uniform. It provides a step by step guide, givi...

    Authors: Ulrike Lorch, Martin O’Kane and Jorg Taubel

    Citation: BMC Medical Research Methodology 2014 14:84

    Published on:

  18. Content type: Research article

    The Patient Reported Outcomes Measurement Information System 43-item short form (PROMIS-43) and the five-level EQ-5D (EQ-5D-5L) are recently developed measures of health-related quality of life (HRQL) that hav...

    Authors: Fang-Ju Lin, A Simon Pickard, Jerry A Krishnan, Min J Joo, David H Au, Shannon S Carson, Suzanne Gillespie, Ashley G Henderson, Peter K Lindenauer, Mary Ann McBurnie, Richard A Mularski, Edward T Naureckas, William M Vollmer and Todd A Lee

    Citation: BMC Medical Research Methodology 2014 14:78

    Published on:

  19. Content type: Research article

    Research on psychological risk factors for injury has focused on stable traits. Our objective was to test the feasibility of a prospective longitudinal study designed to examine labile psychological states as ...

    Authors: Ian Shrier, John S Raglin, Emily B Levitan, Murray A Mittleman, Russell J Steele and Janette Powell

    Citation: BMC Medical Research Methodology 2014 14:77

    Published on:

Previous Page Page 4 of 8 Next Page

2016 Journal Metrics