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BMC Medical Research Methodology

Study design

Section edited by Timothy Beebe

This section considers manuscripts that investigate how choices of research methodology and study design can impact study results, including research participation and study outcomes.

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  1. Content type: Research article

    Informed consent is the foundation of the ethical conduct of health research. Obtaining informed consent may unwittingly interfere with the data collected in research studies, particularly if they concern sens...

    Authors: Lambert Felix, Patrick Keating and Jim McCambridge

    Citation: BMC Medical Research Methodology 2015 15:41

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  2. Content type: Research article

    Survey research in healthcare is an important tool to collect information about healthcare delivery, service use and overall issues relating to quality of care. Unfortunately, physicians are often a group with...

    Authors: Ceara Tess Cunningham, Hude Quan, Brenda Hemmelgarn, Tom Noseworthy, Cynthia A Beck, Elijah Dixon, Susan Samuel, William A Ghali, Lindsay L Sykes and Nathalie Jetté

    Citation: BMC Medical Research Methodology 2015 15:32

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  3. Content type: Research article

    Low participation rates reduce effective sample size, statistical power and can increase risk for selection bias. Previous research suggests that offering choice of participation mode can improve participation...

    Authors: Naomi Heijmans, Jan van Lieshout and Michel Wensing

    Citation: BMC Medical Research Methodology 2015 15:29

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  4. Content type: Research article

    Effective strategies for contacting and recruiting study participants are critical in conducting clinical research. In this study, we conducted two sequential randomized controlled trials of mail- and telephon...

    Authors: Victor D Dinglas, Minxuan Huang, Kristin A Sepulveda, Mariela Pinedo, Ramona O Hopkins, Elizabeth Colantuoni and Dale M Needham

    Citation: BMC Medical Research Methodology 2015 15:5

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  5. Content type: Research article

    General Practitioners (GPs) respond poorly to postal surveys. Consequently there is potential for reduced data quality and bias in the findings. In general population surveys, response to postal questionnaires...

    Authors: Elizabeth Cottrell, Edward Roddy, Trishna Rathod, Elaine Thomas, Mark Porcheret and Nadine E Foster

    Citation: BMC Medical Research Methodology 2015 15:3

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  6. Content type: Research article

    Controlling bias is key to successful randomized controlled trials for behaviour change. Bias can be generated at multiple points during a study, for example, when participants are allocated to different group...

    Authors: Philippe J Giabbanelli and Rik Crutzen

    Citation: BMC Medical Research Methodology 2014 14:130

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  7. Content type: Research article

    Focus groups are commonly used to explore participants’ experiences in health and social care research. Although it is suggested that having demographically homogenous groups may help put participants at ease,...

    Authors: Nan Greenwood, Theresa Ellmers and Jess Holley

    Citation: BMC Medical Research Methodology 2014 14:107

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  8. Content type: Research article

    Paper questionnaires are a common means to collect self-reported information in population-based epidemiological studies. Over the past decades, the response rates to epidemiological studies have been decreasi...

    Authors: Elisa Flüß, Christine M Bond, Gareth T Jones and Gary J Macfarlane

    Citation: BMC Medical Research Methodology 2014 14:104

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  9. Content type: Technical advance

    In 2012 mobile phone numbers were included into the ongoing New South Wales Population Health Survey (NSWPHS) using an overlapping dual-frame design. Previously in the NSWPHS the sample was selected using rand...

    Authors: Margo L Barr, Raymond A Ferguson, Phil J Hughes and David G Steel

    Citation: BMC Medical Research Methodology 2014 14:102

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  10. Content type: Research article

    Randomised controlled trials may be of limited use to evaluate the multidisciplinary and multimodal interventions required to effectively treat complex patients in routine clinical practice; pragmatic action r...

    Authors: Jack J Bell, Tony Rossi, Judith D Bauer and Sandra Capra

    Citation: BMC Medical Research Methodology 2014 14:98

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  11. Content type: Research article

    Insight into local health service provision in rural communities is limited in the literature. The dominant workforce focus in the rural health literature, while revealing issues of shortage of maldistribution...

    Authors: Robyn Adams, Anne Jones, Sophie Lefmann and Lorraine Sheppard

    Citation: BMC Medical Research Methodology 2014 14:94

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  12. Content type: Research article

    Estimates of prevalence are known to be affected by the design of cross-sectional studies. A pan-European study provided an opportunity to compare the effect of two cross-sectional study designs on estimates o...

    Authors: Georgi Nellis, Irja Lutsar, Heili Varendi, Karolin Toompere, Mark A Turner, Jennifer Duncan and Tuuli Metsvaht

    Citation: BMC Medical Research Methodology 2014 14:89

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  13. Content type: Correspondence

    This article attempts to define terminology and to describe a process for writing adaptive, early phase study protocols which are transparent, self-intuitive and uniform. It provides a step by step guide, givi...

    Authors: Ulrike Lorch, Martin O’Kane and Jorg Taubel

    Citation: BMC Medical Research Methodology 2014 14:84

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  14. Content type: Research article

    The Patient Reported Outcomes Measurement Information System 43-item short form (PROMIS-43) and the five-level EQ-5D (EQ-5D-5L) are recently developed measures of health-related quality of life (HRQL) that hav...

    Authors: Fang-Ju Lin, A Simon Pickard, Jerry A Krishnan, Min J Joo, David H Au, Shannon S Carson, Suzanne Gillespie, Ashley G Henderson, Peter K Lindenauer, Mary Ann McBurnie, Richard A Mularski, Edward T Naureckas, William M Vollmer and Todd A Lee

    Citation: BMC Medical Research Methodology 2014 14:78

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  15. Content type: Research article

    Research on psychological risk factors for injury has focused on stable traits. Our objective was to test the feasibility of a prospective longitudinal study designed to examine labile psychological states as ...

    Authors: Ian Shrier, John S Raglin, Emily B Levitan, Murray A Mittleman, Russell J Steele and Janette Powell

    Citation: BMC Medical Research Methodology 2014 14:77

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  16. Content type: Research article

    Sequence symmetry analysis (SSA) is a potential tool for rapid detection of adverse drug events (ADRs) associated with newly marketed medicines utilizing computerized claims data. SSA is robust to patient spec...

    Authors: Nicole L Pratt, Jenni Ilomäki, Chris Raymond and Elizabeth E Roughead

    Citation: BMC Medical Research Methodology 2014 14:66

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  17. Content type: Research article

    Randomized controlled trials that test the effectiveness of mobile health-based weight loss programs are attractive to participants, funders, and researchers because of the low implementation cost, minimal par...

    Authors: Kathryn A Paez, Susan J Griffey, Jennifer Thompson and Matthew W Gillman

    Citation: BMC Medical Research Methodology 2014 14:65

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  18. Content type: Research article

    Many investigators are interested in recruiting veterans from recent conflicts in Afghanistan and Iraq with Traumatic Brain Injury (TBI) and/or Post Traumatic Stress Disorder (PTSD). Researchers pursuing such ...

    Authors: Peter J Bayley, Jennifer Y Kong, Drew A Helmer, Aaron Schneiderman, Lauren A Roselli, Stephanie M Rosse, Jordan A Jackson, Janet Baldwin, Linda Isaac, Michael Nolasco, Marc R Blackman, Matthew J Reinhard, John Wesson Ashford and Julie C Chapman

    Citation: BMC Medical Research Methodology 2014 14:48

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