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Study design

Section edited by Demosthenes Panagiotakos

This section considers manuscripts that investigate how choices of research methodology and study design can impact study results, including research participation and study outcomes.

Page 5 of 8
  1. Content type: Research article

    Sequence symmetry analysis (SSA) is a potential tool for rapid detection of adverse drug events (ADRs) associated with newly marketed medicines utilizing computerized claims data. SSA is robust to patient spec...

    Authors: Nicole L Pratt, Jenni Ilomäki, Chris Raymond and Elizabeth E Roughead

    Citation: BMC Medical Research Methodology 2014 14:66

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  2. Content type: Research article

    Randomized controlled trials that test the effectiveness of mobile health-based weight loss programs are attractive to participants, funders, and researchers because of the low implementation cost, minimal par...

    Authors: Kathryn A Paez, Susan J Griffey, Jennifer Thompson and Matthew W Gillman

    Citation: BMC Medical Research Methodology 2014 14:65

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  3. Content type: Research article

    Many investigators are interested in recruiting veterans from recent conflicts in Afghanistan and Iraq with Traumatic Brain Injury (TBI) and/or Post Traumatic Stress Disorder (PTSD). Researchers pursuing such ...

    Authors: Peter J Bayley, Jennifer Y Kong, Drew A Helmer, Aaron Schneiderman, Lauren A Roselli, Stephanie M Rosse, Jordan A Jackson, Janet Baldwin, Linda Isaac, Michael Nolasco, Marc R Blackman, Matthew J Reinhard, John Wesson Ashford and Julie C Chapman

    Citation: BMC Medical Research Methodology 2014 14:48

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  4. Content type: Research article

    In the UK care homes are one of the main providers of long term care for older people with dementia. Despite the recent increase in care home research, residents with dementia are often excluded from studies. ...

    Authors: Sue L Davies, Claire Goodman, Jill Manthorpe, Adam Smith, Natasha Carrick and Steve Iliffe

    Citation: BMC Medical Research Methodology 2014 14:47

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  5. Content type: Research article

    The effectiveness of multiple innovative recruitment strategies for enrolling Black/African American participants to the Adventist Health Study-2 (AHS-2) is described. The study’s focus is diet and breast, pro...

    Authors: Patti Herring, Terry Butler, Sonja Hall, Hannelore Bennett, Susanne B Montgomery and Gary Fraser

    Citation: BMC Medical Research Methodology 2014 14:46

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  6. Content type: Research article

    Recruiting cancer patients is a barrier often encountered in research trials. However, very few randomized trials explore strategies to improve participation rates. The purpose of this study was to evaluate th...

    Authors: Christine Paul, Ryan Courtney, Rob Sanson-Fisher, Mariko Carey, David Hill, Jody Simmons and Shiho Rose

    Citation: BMC Medical Research Methodology 2014 14:44

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  7. Content type: Research article

    Longitudinal prospective birth cohort studies are pivotal to identifying fundamental causes and determinants of disease and health over the life course. There is limited information about the challenges, reten...

    Authors: Megan Lawrance, Susan M Sayers and Gurmeet R Singh

    Citation: BMC Medical Research Methodology 2014 14:31

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  8. Content type: Research article

    Recruitment to trials is complex and often protracted; selection bias may compromise generalisability. In the mental health field (as elsewhere), diverse factors have been described as hindering researcher acc...

    Authors: Rohan Borschmann, Sue Patterson, Dilkushi Poovendran, Danielle Wilson and Tim Weaver

    Citation: BMC Medical Research Methodology 2014 14:23

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  9. Content type: Research article

    When developing new measuring instruments or deciding upon one for research, consideration of the ‘best’ method of administration for the target population should be made. Current evidence is inconsistent in d...

    Authors: Claudia Rutherford, Jane Nixon, Julia M Brown, Donna L Lamping and Stefan J Cano

    Citation: BMC Medical Research Methodology 2014 14:22

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  10. Content type: Research article

    Vignettes are short stories about a hypothetical person, traditionally used within research (quantitative or qualitative) on sensitive topics in the developed world. Studies using vignettes in the developing w...

    Authors: Annabelle Gourlay, Gerry Mshana, Isolde Birdthistle, Grace Bulugu, Basia Zaba and Mark Urassa

    Citation: BMC Medical Research Methodology 2014 14:21

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  11. Content type: Research article

    Self-reported colorectal cancer (CRC) screening behavior is often subject to over-reporting bias. We examined how the inclusion of a future intention to screen item (viz. asking about future intentions to get scr...

    Authors: Timothy J Beebe, Jeanette Y Ziegenfuss, Sarah M Jenkins, Kandace A Lackore and Timothy P Johnson

    Citation: BMC Medical Research Methodology 2014 14:19

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  12. Content type: Research article

    Gestational diabetes mellitus (GDM) is a risk factor for the development of type 2 diabetes. Lifestyle intervention can prevent progression to type 2 diabetes in high risk populations. We designed a randomised...

    Authors: Jennifer J Infanti, Angela O’Dea, Irene Gibson, Brian E McGuire, John Newell, Liam G Glynn, Ciaran O’Neill, Susan B Connolly and Fidelma P Dunne

    Citation: BMC Medical Research Methodology 2014 14:13

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  13. Content type: Research article

    Recruiting the required number of participants is vital to the success of clinical research and yet many studies fail to achieve their expected recruitment rate. Increasing research participation is a key agen...

    Authors: Lisa Newington and Alison Metcalfe

    Citation: BMC Medical Research Methodology 2014 14:10

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  14. Content type: Research article

    Tracing mail survey responses is useful for the management of reminders but may cause concerns about anonymity among prospective participants. We examined the impact of numbering return envelopes on the partic...

    Authors: Thomas V Perneger, Stéphane Cullati, Sandrine Rudaz, Thomas Agoritsas, Ralph E Schmidt, Christophe Combescure and Delphine S Courvoisier

    Citation: BMC Medical Research Methodology 2014 14:6

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  15. Content type: Erratum

    Authors: Katie Gallacher, Bhautesh Jani, Deborah Morrison, Sara Macdonald, David Blane, Patricia Erwin, Carl R May, Victor M Montori, David T Eton, Fiona Smith, G David Batty and Frances S Mair

    Citation: BMC Medical Research Methodology 2014 13:160

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    The original article was published in BMC Medical Research Methodology 2013 13:10

  16. Content type: Research article

    To assess concordance between Medicare claims and Surveillance, Epidemiology, and End Results (SEER) reports of incident BM among prostate cancer (PCa) patients. The prevalence and consequences of bone metasta...

    Authors: Eberechukwu Onukwugha, Candice Yong, Arif Hussain, Brian Seal and C Daniel Mullins

    Citation: BMC Medical Research Methodology 2014 14:1

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  17. Content type: Research article

    Accrual to Cancer Control and Supportive Care (CCL) studies can be challenging. Our objective was to identify facilitators and perceived barriers to successful Children’s Oncology Group (COG) CCL accrual from ...

    Authors: David VanHoff, Tanya Hesser, Katherine Patterson Kelly, David Freyer, Susan Stork and Lillian Sung

    Citation: BMC Medical Research Methodology 2013 13:154

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  18. Content type: Research article

    The UK leads the world in recruitment of patients to cancer clinical trials, with a six-fold increase in recruitment during 2001–2010. However, there are large variations across cancer centres. This paper deta...

    Authors: Deborah Fenlon, Kim Chivers Seymour, Ikumi Okamoto, Jane Winter, Alison Richardson, Julia Addington-Hall, Jessica L Corner, Peter W Smith, Christine M May, Matthew Breckons and Claire Foster

    Citation: BMC Medical Research Methodology 2013 13:153

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  19. Content type: Research article

    Employing waiting list control designs in psychological and behavioral intervention research may artificially inflate intervention effect estimates. This exploratory randomized controlled trial tested this pro...

    Authors: John A Cunningham, Kypros Kypri and Jim McCambridge

    Citation: BMC Medical Research Methodology 2013 13:150

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