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Study design

Section edited by Demosthenes Panagiotakos

This section considers manuscripts that investigate how choices of research methodology and study design can impact study results, including research participation and study outcomes.

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  1. Content type: Research article

    Paper questionnaires are a common means to collect self-reported information in population-based epidemiological studies. Over the past decades, the response rates to epidemiological studies have been decreasi...

    Authors: Elisa Flüß, Christine M Bond, Gareth T Jones and Gary J Macfarlane

    Citation: BMC Medical Research Methodology 2014 14:104

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  2. Content type: Technical advance

    In 2012 mobile phone numbers were included into the ongoing New South Wales Population Health Survey (NSWPHS) using an overlapping dual-frame design. Previously in the NSWPHS the sample was selected using rand...

    Authors: Margo L Barr, Raymond A Ferguson, Phil J Hughes and David G Steel

    Citation: BMC Medical Research Methodology 2014 14:102

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  3. Content type: Research article

    Randomised controlled trials may be of limited use to evaluate the multidisciplinary and multimodal interventions required to effectively treat complex patients in routine clinical practice; pragmatic action r...

    Authors: Jack J Bell, Tony Rossi, Judith D Bauer and Sandra Capra

    Citation: BMC Medical Research Methodology 2014 14:98

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  4. Content type: Research article

    Insight into local health service provision in rural communities is limited in the literature. The dominant workforce focus in the rural health literature, while revealing issues of shortage of maldistribution...

    Authors: Robyn Adams, Anne Jones, Sophie Lefmann and Lorraine Sheppard

    Citation: BMC Medical Research Methodology 2014 14:94

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  5. Content type: Research article

    Estimates of prevalence are known to be affected by the design of cross-sectional studies. A pan-European study provided an opportunity to compare the effect of two cross-sectional study designs on estimates o...

    Authors: Georgi Nellis, Irja Lutsar, Heili Varendi, Karolin Toompere, Mark A Turner, Jennifer Duncan and Tuuli Metsvaht

    Citation: BMC Medical Research Methodology 2014 14:89

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  6. Content type: Correspondence

    This article attempts to define terminology and to describe a process for writing adaptive, early phase study protocols which are transparent, self-intuitive and uniform. It provides a step by step guide, givi...

    Authors: Ulrike Lorch, Martin O’Kane and Jorg Taubel

    Citation: BMC Medical Research Methodology 2014 14:84

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  7. Content type: Research article

    The Patient Reported Outcomes Measurement Information System 43-item short form (PROMIS-43) and the five-level EQ-5D (EQ-5D-5L) are recently developed measures of health-related quality of life (HRQL) that hav...

    Authors: Fang-Ju Lin, A Simon Pickard, Jerry A Krishnan, Min J Joo, David H Au, Shannon S Carson, Suzanne Gillespie, Ashley G Henderson, Peter K Lindenauer, Mary Ann McBurnie, Richard A Mularski, Edward T Naureckas, William M Vollmer and Todd A Lee

    Citation: BMC Medical Research Methodology 2014 14:78

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  8. Content type: Research article

    Research on psychological risk factors for injury has focused on stable traits. Our objective was to test the feasibility of a prospective longitudinal study designed to examine labile psychological states as ...

    Authors: Ian Shrier, John S Raglin, Emily B Levitan, Murray A Mittleman, Russell J Steele and Janette Powell

    Citation: BMC Medical Research Methodology 2014 14:77

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  9. Content type: Research article

    Sequence symmetry analysis (SSA) is a potential tool for rapid detection of adverse drug events (ADRs) associated with newly marketed medicines utilizing computerized claims data. SSA is robust to patient spec...

    Authors: Nicole L Pratt, Jenni Ilomäki, Chris Raymond and Elizabeth E Roughead

    Citation: BMC Medical Research Methodology 2014 14:66

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  10. Content type: Research article

    Randomized controlled trials that test the effectiveness of mobile health-based weight loss programs are attractive to participants, funders, and researchers because of the low implementation cost, minimal par...

    Authors: Kathryn A Paez, Susan J Griffey, Jennifer Thompson and Matthew W Gillman

    Citation: BMC Medical Research Methodology 2014 14:65

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  11. Content type: Research article

    Many investigators are interested in recruiting veterans from recent conflicts in Afghanistan and Iraq with Traumatic Brain Injury (TBI) and/or Post Traumatic Stress Disorder (PTSD). Researchers pursuing such ...

    Authors: Peter J Bayley, Jennifer Y Kong, Drew A Helmer, Aaron Schneiderman, Lauren A Roselli, Stephanie M Rosse, Jordan A Jackson, Janet Baldwin, Linda Isaac, Michael Nolasco, Marc R Blackman, Matthew J Reinhard, John Wesson Ashford and Julie C Chapman

    Citation: BMC Medical Research Methodology 2014 14:48

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  12. Content type: Research article

    In the UK care homes are one of the main providers of long term care for older people with dementia. Despite the recent increase in care home research, residents with dementia are often excluded from studies. ...

    Authors: Sue L Davies, Claire Goodman, Jill Manthorpe, Adam Smith, Natasha Carrick and Steve Iliffe

    Citation: BMC Medical Research Methodology 2014 14:47

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  13. Content type: Research article

    The effectiveness of multiple innovative recruitment strategies for enrolling Black/African American participants to the Adventist Health Study-2 (AHS-2) is described. The study’s focus is diet and breast, pro...

    Authors: Patti Herring, Terry Butler, Sonja Hall, Hannelore Bennett, Susanne B Montgomery and Gary Fraser

    Citation: BMC Medical Research Methodology 2014 14:46

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  14. Content type: Research article

    Recruiting cancer patients is a barrier often encountered in research trials. However, very few randomized trials explore strategies to improve participation rates. The purpose of this study was to evaluate th...

    Authors: Christine Paul, Ryan Courtney, Rob Sanson-Fisher, Mariko Carey, David Hill, Jody Simmons and Shiho Rose

    Citation: BMC Medical Research Methodology 2014 14:44

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  15. Content type: Research article

    Longitudinal prospective birth cohort studies are pivotal to identifying fundamental causes and determinants of disease and health over the life course. There is limited information about the challenges, reten...

    Authors: Megan Lawrance, Susan M Sayers and Gurmeet R Singh

    Citation: BMC Medical Research Methodology 2014 14:31

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  16. Content type: Research article

    Recruitment to trials is complex and often protracted; selection bias may compromise generalisability. In the mental health field (as elsewhere), diverse factors have been described as hindering researcher acc...

    Authors: Rohan Borschmann, Sue Patterson, Dilkushi Poovendran, Danielle Wilson and Tim Weaver

    Citation: BMC Medical Research Methodology 2014 14:23

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  17. Content type: Research article

    When developing new measuring instruments or deciding upon one for research, consideration of the ‘best’ method of administration for the target population should be made. Current evidence is inconsistent in d...

    Authors: Claudia Rutherford, Jane Nixon, Julia M Brown, Donna L Lamping and Stefan J Cano

    Citation: BMC Medical Research Methodology 2014 14:22

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  18. Content type: Research article

    Vignettes are short stories about a hypothetical person, traditionally used within research (quantitative or qualitative) on sensitive topics in the developed world. Studies using vignettes in the developing w...

    Authors: Annabelle Gourlay, Gerry Mshana, Isolde Birdthistle, Grace Bulugu, Basia Zaba and Mark Urassa

    Citation: BMC Medical Research Methodology 2014 14:21

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  19. Content type: Research article

    Self-reported colorectal cancer (CRC) screening behavior is often subject to over-reporting bias. We examined how the inclusion of a future intention to screen item (viz. asking about future intentions to get scr...

    Authors: Timothy J Beebe, Jeanette Y Ziegenfuss, Sarah M Jenkins, Kandace A Lackore and Timothy P Johnson

    Citation: BMC Medical Research Methodology 2014 14:19

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