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BMC Medical Research Methodology

Study design

Section edited by Timothy Beebe

This section considers manuscripts that investigate how choices of research methodology and study design can impact study results, including research participation and study outcomes.

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  1. Content type: Debate

    Epidemiologic studies often struggle to adequately represent populations and outcomes of interest. Differences in methodology, data analysis and research questions often mean that reviews and synthesis of the ...

    Authors: Joanne Allen, Kerry J Inder, Terry J Lewin, John R Attia, Frances J Kay-Lambkin, Amanda L Baker, Trevor Hazell and Brian J Kelly

    Citation: BMC Medical Research Methodology 2013 13:122

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  2. Content type: Research article

    Measurement of health-related quality of life (HRQoL) in dementia is difficult. At some point people with dementia become unable to meaningfully assess their own HRQoL. At such a point in time researchers need...

    Authors: Alexander MM Arons, Paul FM Krabbe, Carla JM Schölzel-Dorenbos, Gert Jan van der Wilt and Marcel GM Olde Rikkert

    Citation: BMC Medical Research Methodology 2013 13:110

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  3. Content type: Research article

    There is little published guidance as to the sample size required for a pilot or feasibility trial despite the fact that a sample size justification is a key element in the design of a trial. A sample size jus...

    Authors: Sophie AM Billingham, Amy L Whitehead and Steven A Julious

    Citation: BMC Medical Research Methodology 2013 13:104

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  4. Content type: Research article

    The counterfactual approach provides a clear and coherent framework to think about a variety of important concepts related to causation. Meanwhile, directed acyclic graphs have been used as causal diagrams in ...

    Authors: Etsuji Suzuki, Toshiharu Mitsuhashi, Toshihide Tsuda and Eiji Yamamoto

    Citation: BMC Medical Research Methodology 2013 13:101

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  5. Content type: Correspondence

    Many researchers favor repeated measures designs because they allow the detection of within-person change over time and typically have higher statistical power than cross-sectional designs. However, the pletho...

    Authors: Yi Guo, Henrietta L Logan, Deborah H Glueck and Keith E Muller

    Citation: BMC Medical Research Methodology 2013 13:100

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  6. Content type: Research article

    Cognitive mapping is a participatory research methodology that documents, in visual form, a construct of the local environment in which people live and work. We adapted this method to provide detailed data abo...

    Authors: Jonathan Stadler, Charles Dugmore, Emilie Venables, Catherine MacPhail and Sinead Delany-Moretlwe

    Citation: BMC Medical Research Methodology 2013 13:96

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  7. Content type: Research article

    Longitudinal cohort studies are highly valued in epidemiologic research for their ability to establish exposure-disease associations through known temporal sequences. A major challenge in cohort studies is rec...

    Authors: Jaime L Horton, Isabel G Jacobson, Alyson J Littman, John E Alcaraz, Besa Smith and Nancy F Crum-Cianflone

    Citation: BMC Medical Research Methodology 2013 13:90

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  8. Content type: Research article

    As there are limited patients for chronic lymphocytic leukaemia trials, it is important that statistical methodologies in Phase II efficiently select regimens for subsequent evaluation in larger-scale Phase II...

    Authors: Christina Yap, Andrew Pettitt and Lucinda Billingham

    Citation: BMC Medical Research Methodology 2013 13:87

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  9. Content type: Research article

    The use of teams is a well-known approach in a variety of settings, including health care, in both developed and developing countries. Team performance is comprised of teamwork and task work, and ascertaining ...

    Authors: Kojo Yeboah-Antwi, Gail Snetro-Plewman, Karen Z Waltensperger, Davidson H Hamer, Chilobe Kambikambi, William MacLeod, Stephen Filumba, Bias Sichamba and David Marsh

    Citation: BMC Medical Research Methodology 2013 13:84

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  10. Content type: Research article

    To compare the results of a new-user cohort study design and the self-controlled case series (SCCS) design using the risk of hospitalisation for pneumonia in those dispensed proton pump inhibitors compared to ...

    Authors: Emmae N Ramsay, Nicole L Pratt, Philip Ryan and Elizabeth E Roughead

    Citation: BMC Medical Research Methodology 2013 13:82

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  11. Content type: Research article

    Drug interactions can have a significant impact on the response to combinatorial therapy for anticancer treatment. In some instances these interactions can be anticipated based on pre-clinical models. However,...

    Authors: Wenfeng Kang, Robert S DiPaola and Alexei Vazquez

    Citation: BMC Medical Research Methodology 2013 13:77

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  12. Content type: Research article

    Non-inferiority (NI) trials in drug research are used to demonstrate that a new treatment is not less effective than an active comparator. Since phase IV trials typically aim at informing a clinical decision, ...

    Authors: Rosemarie DLC Bernabe, Grace Wangge, Mirjam J Knol, Olaf H Klungel, Johannes JM van Delden, Anthonius de Boer, Arno W Hoes, Jan AM Raaijmakers and Ghislaine JMW van Thiel

    Citation: BMC Medical Research Methodology 2013 13:70

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  13. Content type: Correspondence

    The quality of a consultation provided by a physician can have a profound impact on the quality of care and patient engagement in treatment decisions. When the COPD Assessment Test (CAT) was developed, one of ...

    Authors: Kevin Gruffydd-Jones, Helen Marsden, Steve Holmes, Peter Kardos, Roger Escamilla, Roberto Dal Negro, June Roberts, Gilbert Nadeau, David Leather and Paul Jones

    Citation: BMC Medical Research Methodology 2013 13:63

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  14. Content type: Research article

    The study describes the methodological challenges encountered in an observational study estimating the effectiveness of colonoscopy in reducing colorectal cancer (CRC) incidence and mortality.

    Authors: Binu J Jacob, Rinku Sutradhar, Rahim Moineddin, Nancy N Baxter and David R Urbach

    Citation: BMC Medical Research Methodology 2013 13:59

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  15. Content type: Research article

    Using covariance or mean estimates from previous data introduces randomness into each power value in a power curve. Creating confidence intervals about the power estimates improves study planning by allowing s...

    Authors: Matthew J Gribbin, Yueh-Yun Chi, Paul W Stewart and Keith E Muller

    Citation: BMC Medical Research Methodology 2013 13:57

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  16. Content type: Research article

    The role of the clinical nurse/midwife specialist and advanced nurse/midwife practitioner is complex not least because of the diversity in how the roles are operationalised across health settings and within mu...

    Authors: Joan G Lalor, Dympna Casey, Naomi Elliott, Imelda Coyne, Catherine Comiskey, Agnes Higgins, Kathy Murphy, Declan Devane and Cecily Begley

    Citation: BMC Medical Research Methodology 2013 13:55

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  17. Content type: Reviewer acknowledgement

    The editors of BMC Medical Research Methodology would like to thank all our reviewers who have contributed to the journal in Volume 12 (2012).

    Authors: Adrian Aldcroft

    Citation: BMC Medical Research Methodology 2013 13:45

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  18. Content type: Debate

    Scoping studies are increasingly common for broadly searching the literature on a specific topic, yet researchers lack an agreed-upon definition of and framework for the methodology. In 2005, Arksey and O’Mall...

    Authors: Helena ML Daudt, Catherine van Mossel and Samantha J Scott

    Citation: BMC Medical Research Methodology 2013 13:48

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