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Study design

Section edited by Demosthenes Panagiotakos

This section considers manuscripts that investigate how choices of research methodology and study design can impact study results, including research participation and study outcomes.

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  1. Content type: Research article

    Tracing mail survey responses is useful for the management of reminders but may cause concerns about anonymity among prospective participants. We examined the impact of numbering return envelopes on the partic...

    Authors: Thomas V Perneger, Stéphane Cullati, Sandrine Rudaz, Thomas Agoritsas, Ralph E Schmidt, Christophe Combescure and Delphine S Courvoisier

    Citation: BMC Medical Research Methodology 2014 14:6

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  2. Content type: Erratum

    Authors: Katie Gallacher, Bhautesh Jani, Deborah Morrison, Sara Macdonald, David Blane, Patricia Erwin, Carl R May, Victor M Montori, David T Eton, Fiona Smith, G David Batty and Frances S Mair

    Citation: BMC Medical Research Methodology 2014 13:160

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    The original article was published in BMC Medical Research Methodology 2013 13:10

  3. Content type: Research article

    To assess concordance between Medicare claims and Surveillance, Epidemiology, and End Results (SEER) reports of incident BM among prostate cancer (PCa) patients. The prevalence and consequences of bone metasta...

    Authors: Eberechukwu Onukwugha, Candice Yong, Arif Hussain, Brian Seal and C Daniel Mullins

    Citation: BMC Medical Research Methodology 2014 14:1

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  4. Content type: Research article

    Accrual to Cancer Control and Supportive Care (CCL) studies can be challenging. Our objective was to identify facilitators and perceived barriers to successful Children’s Oncology Group (COG) CCL accrual from ...

    Authors: David VanHoff, Tanya Hesser, Katherine Patterson Kelly, David Freyer, Susan Stork and Lillian Sung

    Citation: BMC Medical Research Methodology 2013 13:154

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  5. Content type: Research article

    The UK leads the world in recruitment of patients to cancer clinical trials, with a six-fold increase in recruitment during 2001–2010. However, there are large variations across cancer centres. This paper deta...

    Authors: Deborah Fenlon, Kim Chivers Seymour, Ikumi Okamoto, Jane Winter, Alison Richardson, Julia Addington-Hall, Jessica L Corner, Peter W Smith, Christine M May, Matthew Breckons and Claire Foster

    Citation: BMC Medical Research Methodology 2013 13:153

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  6. Content type: Research article

    Employing waiting list control designs in psychological and behavioral intervention research may artificially inflate intervention effect estimates. This exploratory randomized controlled trial tested this pro...

    Authors: John A Cunningham, Kypros Kypri and Jim McCambridge

    Citation: BMC Medical Research Methodology 2013 13:150

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  7. Content type: Research article

    Randomised controlled trials are becoming increasingly costly and time-consuming. In 2011, Royston and colleagues proposed a particular class of multi-arm multi-stage (MAMS) designs intended to speed up the ev...

    Authors: Daniel J Bratton, Patrick PJ Phillips and Mahesh KB Parmar

    Citation: BMC Medical Research Methodology 2013 13:139

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  8. Content type: Research article

    The way in which maternity care is provided affects perinatal outcomes for pregnant adolescents; including the likelihood of preterm birth. The study purpose was to assess the feasibility of recruiting pregnan...

    Authors: Jyai Allen, Helen Stapleton, Sally Tracy and Sue Kildea

    Citation: BMC Medical Research Methodology 2013 13:138

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  9. Content type: Research article

    The Current Opioid Misuse Measure (COMM) is a self-report questionnaire designed to help identify aberrant drug-related behavior in respondents who have been prescribed opioids for chronic pain. The full-lengt...

    Authors: Matthew D Finkelman, Ronald J Kulich, Driss Zoukhri, Niels Smits and Stephen F Butler

    Citation: BMC Medical Research Methodology 2013 13:126

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  10. Content type: Research article

    Treatment duration varies with the type of therapy and a patient’s recovery speed. Including such a variation in randomized controlled trials (RCTs) enables comparison of the actual therapeutic potential of di...

    Authors: Hilbert W van der Glas and Robert J van Grootel

    Citation: BMC Medical Research Methodology 2013 13:123

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  11. Content type: Debate

    Epidemiologic studies often struggle to adequately represent populations and outcomes of interest. Differences in methodology, data analysis and research questions often mean that reviews and synthesis of the ...

    Authors: Joanne Allen, Kerry J Inder, Terry J Lewin, John R Attia, Frances J Kay-Lambkin, Amanda L Baker, Trevor Hazell and Brian J Kelly

    Citation: BMC Medical Research Methodology 2013 13:122

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  12. Content type: Research article

    Measurement of health-related quality of life (HRQoL) in dementia is difficult. At some point people with dementia become unable to meaningfully assess their own HRQoL. At such a point in time researchers need...

    Authors: Alexander MM Arons, Paul FM Krabbe, Carla JM Schölzel-Dorenbos, Gert Jan van der Wilt and Marcel GM Olde Rikkert

    Citation: BMC Medical Research Methodology 2013 13:110

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  13. Content type: Research article

    There is little published guidance as to the sample size required for a pilot or feasibility trial despite the fact that a sample size justification is a key element in the design of a trial. A sample size jus...

    Authors: Sophie AM Billingham, Amy L Whitehead and Steven A Julious

    Citation: BMC Medical Research Methodology 2013 13:104

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  14. Content type: Research article

    The counterfactual approach provides a clear and coherent framework to think about a variety of important concepts related to causation. Meanwhile, directed acyclic graphs have been used as causal diagrams in ...

    Authors: Etsuji Suzuki, Toshiharu Mitsuhashi, Toshihide Tsuda and Eiji Yamamoto

    Citation: BMC Medical Research Methodology 2013 13:101

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  15. Content type: Correspondence

    Many researchers favor repeated measures designs because they allow the detection of within-person change over time and typically have higher statistical power than cross-sectional designs. However, the pletho...

    Authors: Yi Guo, Henrietta L Logan, Deborah H Glueck and Keith E Muller

    Citation: BMC Medical Research Methodology 2013 13:100

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  16. Content type: Research article

    Cognitive mapping is a participatory research methodology that documents, in visual form, a construct of the local environment in which people live and work. We adapted this method to provide detailed data abo...

    Authors: Jonathan Stadler, Charles Dugmore, Emilie Venables, Catherine MacPhail and Sinead Delany-Moretlwe

    Citation: BMC Medical Research Methodology 2013 13:96

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  17. Content type: Research article

    Longitudinal cohort studies are highly valued in epidemiologic research for their ability to establish exposure-disease associations through known temporal sequences. A major challenge in cohort studies is rec...

    Authors: Jaime L Horton, Isabel G Jacobson, Alyson J Littman, John E Alcaraz, Besa Smith and Nancy F Crum-Cianflone

    Citation: BMC Medical Research Methodology 2013 13:90

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  18. Content type: Research article

    As there are limited patients for chronic lymphocytic leukaemia trials, it is important that statistical methodologies in Phase II efficiently select regimens for subsequent evaluation in larger-scale Phase II...

    Authors: Christina Yap, Andrew Pettitt and Lucinda Billingham

    Citation: BMC Medical Research Methodology 2013 13:87

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  19. Content type: Research article

    The use of teams is a well-known approach in a variety of settings, including health care, in both developed and developing countries. Team performance is comprised of teamwork and task work, and ascertaining ...

    Authors: Kojo Yeboah-Antwi, Gail Snetro-Plewman, Karen Z Waltensperger, Davidson H Hamer, Chilobe Kambikambi, William MacLeod, Stephen Filumba, Bias Sichamba and David Marsh

    Citation: BMC Medical Research Methodology 2013 13:84

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