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  1. The last decade has seen a number of methodological developments in meta-analysis of diagnostic test studies. However, it is unclear whether such developments have permeated the wider research community and on...

    Authors: Brian H Willis and Muireann Quigley

    Citation: BMC Medical Research Methodology 2011 11:27

    Content type: Research article

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  2. Administrative health care databases offer an efficient and accessible, though as-yet unvalidated, approach to studying outcomes of patients with chronic kidney disease and end-stage renal disease (ESRD). The ...

    Authors: Fiona M Clement, Matthew T James, Rick Chin, Scott W Klarenbach, Braden J Manns, Robert R Quinn, Pietro Ravani, Marcello Tonelli and Brenda R Hemmelgarn

    Citation: BMC Medical Research Methodology 2011 11:25

    Content type: Research article

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  3. The development, implementation and evaluation of any new health intervention is complex. This paper uses experiences from the design, implementation and evaluation of a rehabilitation programme to shed light ...

    Authors: Lydia Bird, Antony Arthur and Karen Cox

    Citation: BMC Medical Research Methodology 2011 11:24

    Content type: Research article

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  4. Clinical practice guidelines are an important element of evidence-based practice. Considering an often complicated body of evidence can be problematic for guideline developers, who in the past may have resorte...

    Authors: Susan Hillier, Karen Grimmer-Somers, Tracy Merlin, Philippa Middleton, Janet Salisbury, Rebecca Tooher and Adele Weston

    Citation: BMC Medical Research Methodology 2011 11:23

    Content type: Research article

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  5. Dealing with heterogeneity in meta-analyses is often tricky, and there is only limited advice for authors on what to do. We investigated how authors addressed different degrees of heterogeneity, in particular ...

    Authors: Jeppe B Schroll, Rasmus Moustgaard and Peter C Gøtzsche

    Citation: BMC Medical Research Methodology 2011 11:22

    Content type: Research article

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  6. Multicentre randomized controlled trials (RCTs) routinely use randomization and analysis stratified by centre to control for differences between centres and to improve precision. No consensus has been reached ...

    Authors: Rong Chu, Lehana Thabane, Jinhui Ma, Anne Holbrook, Eleanor Pullenayegum and Philip James Devereaux

    Citation: BMC Medical Research Methodology 2011 11:21

    Content type: Research article

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  7. Collecting population data on sensitive issues such as non-suicidal self-injury (NSSI) is problematic. Case note audits or hospital/clinic based presentations only record severe cases and do not distinguish be...

    Authors: Anne W Taylor, Graham Martin, Eleonora Dal Grande, Sarah Swannell, Simon Fullerton, Philip Hazell and James E Harrison

    Citation: BMC Medical Research Methodology 2011 11:20

    Content type: Research article

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  8. Attrition, which leads to missing data, is a common problem in cluster randomized trials (CRTs), where groups of patients rather than individuals are randomized. Standard multiple imputation (MI) strategies ma...

    Authors: Jinhui Ma, Noori Akhtar-Danesh, Lisa Dolovich and Lehana Thabane

    Citation: BMC Medical Research Methodology 2011 11:18

    Content type: Research article

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  9. Many research projects in general practice face problems when recruiting patients, often resulting in low recruitment rates and an unknown selection bias, thus limiting their value for health services research...

    Authors: Stephanie Heinemann, Sabine Thüring, Sven Wedeken, Tobias Schäfer, Christa Scheidt-Nave, Mirko Ketterer and Wolfgang Himmel

    Citation: BMC Medical Research Methodology 2011 11:16

    Content type: Research article

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  10. Hundreds of studies of maternity care interventions have been published, too many for most people involved in providing maternity care to identify and consider when making decisions. It became apparent that sy...

    Authors: Valerie Smith, Declan Devane, Cecily M Begley and Mike Clarke

    Citation: BMC Medical Research Methodology 2011 11:15

    Content type: Research article

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  11. Current methodological guidelines provide advice about the assessment of sub-group analysis within RCTs, but do not specify explicit criteria for assessment. Our objective was to provide researchers with a set...

    Authors: Tamar Pincus, Clare Miles, Robert Froud, Martin Underwood, Dawn Carnes and Stephanie JC Taylor

    Citation: BMC Medical Research Methodology 2011 11:14

    Content type: Research article

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  12. Heart failure is a highly debilitating syndrome with a poor prognosis primarily affecting the elderly. Clinicians wanting timely access to heart failure evidence to provide optimal patient care can face many c...

    Authors: Raechel A Damarell, Jennifer Tieman, Ruth M Sladek and Patricia M Davidson

    Citation: BMC Medical Research Methodology 2011 11:12

    Content type: Research article

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  13. In research, diagrams are most commonly used in the analysis of data and visual presentation of results. However there has been a substantial growth in the use of diagrams in earlier stages of the research pro...

    Authors: Muriah J Umoquit, Peggy Tso, Helen ED Burchett and Mark J Dobrow

    Citation: BMC Medical Research Methodology 2011 11:11

    Content type: Research article

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  14. There is a growing ethical imperative to feedback research results to participants but there remains a striking lack of empirical research on how people respond to individualised feedback. We sought to explore...

    Authors: Karen Lorimer, Cindy M Gray, Kate Hunt, Sally Wyke, Annie Anderson and Michaela Benzeval

    Citation: BMC Medical Research Methodology 2011 11:10

    Content type: Research article

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  15. To describe the development of a dementia research registry, outlining the conceptual, practical and ethical challenges, and to report initial experiences of recruiting people with dementia to it from primary ...

    Authors: Steve Iliffe, Lisa Curry, Kalpa Kharicha, Greta Rait, Jane Wilcock, David Lowery, Archana Tapuria, Dipak Kalra and Craig Ritchie

    Citation: BMC Medical Research Methodology 2011 11:9

    Content type: Correspondence

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  16. Randomised controlled trials have investigated aspects of postal survey design yet cannot elaborate on reasons behind participants' decision making and survey behaviour. This paper reports participants' perspe...

    Authors: Helen Harcombe, Sarah Derrett, Peter Herbison and David McBride

    Citation: BMC Medical Research Methodology 2011 11:8

    Content type: Research article

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  17. Data on lifetime exposures are often self-reported in epidemiologic studies, sometimes many years after the relevant age. Validity of self-reported data is usually inferred from their agreement with measured v...

    Authors: Benjamin J Cairns, Bette Liu, Suzanne Clennell, Rachel Cooper, Gillian K Reeves, Valerie Beral and Diana Kuh

    Citation: BMC Medical Research Methodology 2011 11:7

    Content type: Research article

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  18. Route environments can positively influence people's active commuting and thereby contribute to public health. The Active Commuting Route Environment Scale (ACRES) was developed to study active commuters' perc...

    Authors: Lina Wahlgren and Peter Schantz

    Citation: BMC Medical Research Methodology 2011 11:6

    Content type: Research article

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  19. Recruiting large and representative samples of adolescent and young adult (AYA) cancer survivors is important for gaining accurate data regarding the prevalence of unmet needs in this population. This study ai...

    Authors: Tara Clinton-McHarg, Mariko Carey, Rob Sanson-Fisher and Elizabeth Tracey

    Citation: BMC Medical Research Methodology 2011 11:5

    Content type: Research article

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  20. We investigate methods used to analyse the results of clinical trials with survival outcomes in which some patients switch from their allocated treatment to another trial treatment. These included simple metho...

    Authors: James P Morden, Paul C Lambert, Nicholas Latimer, Keith R Abrams and Allan J Wailoo

    Citation: BMC Medical Research Methodology 2011 11:4

    Content type: Research article

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  21. Reviews of randomized controlled trials (RCTs) of cognitive behavioural therapy (CBT) for anxiety disorders have reported large pre- to post-treatment within-group effect sizes on measures of anxiety when supp...

    Authors: Joakim Ekberg, Toomas Timpka, Magnus Bång, Anders Fröberg, Karin Halje and Henrik Eriksson

    Citation: BMC Medical Research Methodology 2011 11:3

    Content type: Study protocol

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  22. Autism spectrum disorders (ASD) are associated with complications of pregnancy that implicate fetal hypoxia (FH); the excess of ASD in male gender is poorly understood. We tested the hypothesis that risk of AS...

    Authors: Igor Burstyn, Xiaoming Wang, Yutaka Yasui, Fortune Sithole and Lonnie Zwaigenbaum

    Citation: BMC Medical Research Methodology 2011 11:2

    Content type: Research article

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  23. Previous studies have proposed a simple product-based estimator for calculating exposure-specific risks (ESR), but the methodology has not been rigorously evaluated. The goal of our study was to evaluate the e...

    Authors: William M Reichmann, David Gagnon, C Robert Horsburgh and Elena Losina

    Citation: BMC Medical Research Methodology 2011 11:1

    Content type: Research article

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  24. The appropriate handling of missing covariate data in prognostic modelling studies is yet to be conclusively determined. A resampling study was performed to investigate the effects of different missing data me...

    Authors: Andrea Marshall, Douglas G Altman and Roger L Holder

    Citation: BMC Medical Research Methodology 2010 10:112

    Content type: Research article

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  25. Measuring the real burden of cardiovascular disease in Australian Aboriginals is complicated by under-identification of Aboriginality in administrative health data collections. Accurate data is essential to me...

    Authors: Tom G Briffa, Frank M Sanfilippo, Michael ST Hobbs, Stephen C Ridout, Judy M Katzenellenbogen, Peter L Thompson and Sandra C Thompson

    Citation: BMC Medical Research Methodology 2010 10:111

    Content type: Research article

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  26. The purpose of this study was to explore women's views of the design of a large pragmatic cost-effectiveness randomised controlled trial of the policy of offering a health professional-delivered intervention t...

    Authors: Lindsay JL Forbes, Carol McNaughton Nicholls, Louise Linsell, Jenny Graham, Charlotte Tompkins and Amanda J Ramirez

    Citation: BMC Medical Research Methodology 2010 10:110

    Content type: Research article

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  27. While some research has been conducted examining recruitment methods to engage physicians and practices in primary care research, further research is needed on recruitment methodology as it remains a recurrent...

    Authors: Sharon Johnston, Clare Liddy, William Hogg, Melissa Donskov, Grant Russell and Elizabeth Gyorfi-Dyke

    Citation: BMC Medical Research Methodology 2010 10:109

    Content type: Research article

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  28. Automatic variable selection methods are usually discouraged in medical research although we believe they might be valuable for studies where subject matter knowledge is limited. Bayesian model averaging may b...

    Authors: Anna Genell, Szilard Nemes, Gunnar Steineck and Paul W Dickman

    Citation: BMC Medical Research Methodology 2010 10:108

    Content type: Research article

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  29. Gene-environment interactions are likely to explain some of the heterogeneity in childhood asthma. Here, we describe the methodology and experiences in establishing a database for childhood asthma designed to ...

    Authors: Stephen W Turner, Jon G Ayres, Tatiana V Macfarlane, Anil Mehta, Gita Mehta, Colin N Palmer, Steve Cunningham, Tim Adams, Krishnan Aniruddhan, Claire Bell, Donna Corrigan, Jason Cunningham, Andrew Duncan, Gerard Hunt, Richard Leece, Una MacFadyen…

    Citation: BMC Medical Research Methodology 2010 10:107

    Content type: Research article

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  30. Standardised translation and cross-cultural adaptation (TCCA) procedures are vital to describe language translation, cultural adaptation, and to evaluate quality factors of transformed outcome measures. No TCC...

    Authors: Corina Schuster, Sabine Hahn and Thierry Ettlin

    Citation: BMC Medical Research Methodology 2010 10:106

    Content type: Research article

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  31. Self-monitoring is increasingly recommended as a method of managing cardiovascular disease. However, the design, implementation and reproducibility of the self-monitoring interventions appear to vary considera...

    Authors: Alison M Ward, Carl Heneghan, Rafael Perera, Dan Lasserson, David Nunan, David Mant and Paul Glasziou

    Citation: BMC Medical Research Methodology 2010 10:105

    Content type: Research article

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  32. This study carried out to develop a scale for assessing diabetic patients' perceptions about physical activity and to test its psychometric properties (The Physical Activity Questionnaire for Diabetic Patients...

    Authors: Zeinab Ghazanfari, Shamsaddin Niknami, Fazlollah Ghofranipour, Ebrahim Hajizadeh and Ali Montazeri

    Citation: BMC Medical Research Methodology 2010 10:104

    Content type: Research article

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  33. Although the general statistical advice is to keep continuous exposure variables as continuous in statistical analyses, categorisation is still a common approach in medical research. In a recent paper from the...

    Authors: Kathrine F Frøslie, Jo Røislien, Petter Laake, Tore Henriksen, Elisabeth Qvigstad and Marit B Veierød

    Citation: BMC Medical Research Methodology 2010 10:103

    Content type: Correspondence

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  34. Anthropometric measurements are a non invasive, inexpensive, and suitable method for evaluating the nutritional status in population studies with relatively large sample sizes. However, anthropometric techniqu...

    Authors: Maryline Sicotte, Marielle Ledoux, Maria-Victoria Zunzunegui, Souleymane Ag Aboubacrine and Vinh-Kim Nguyen

    Citation: BMC Medical Research Methodology 2010 10:102

    Content type: Research article

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  35. High accrual to clinical trials enables new treatment strategies to be tested rapidly, accurately and with generalisability. Ethical standards also must be high so that participation is voluntary and informed....

    Authors: Lucie MT Byrne-Davis, Peter Salmon, Katja Gravenhorst, Tim OB Eden and Bridget Young

    Citation: BMC Medical Research Methodology 2010 10:101

    Content type: Research article

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  36. Childhood obesity is associated with the early development of diseases such as type 2 diabetes and cardiovascular disease. Unfortunately, to date, traditional methods of research have failed to identify effect...

    Authors: Matthew A Sabin, Susan L Clemens, Richard Saffery, Zoe McCallum, Michele W Campbell, Wieland Kiess, Nancy A Crimmins, Jessica G Woo, Gary M Leong, George A Werther, Obioha C Ukoumunne and Melissa A Wake

    Citation: BMC Medical Research Methodology 2010 10:100

    Content type: Correspondence

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  37. Nonresponse bias in a longitudinal study could affect the magnitude and direction of measures of association. We identified sociodemographic, behavioral, military, and health-related predictors of response to ...

    Authors: Alyson J Littman, Edward J Boyko, Isabel G Jacobson, Jaime Horton, Gary D Gackstetter, Besa Smith, Tomoko Hooper, Timothy S Wells, Paul J Amoroso and Tyler C Smith

    Citation: BMC Medical Research Methodology 2010 10:99

    Content type: Research article

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  38. The physiological responses to hypoxaemia and cellular hypoxia are poorly understood, and inter-individual differences in performance at altitude and outcome in critical illness remain unexplained. We propose ...

    Authors: Denny ZH Levett, Daniel S Martin, Mark H Wilson, Kay Mitchell, Sundeep Dhillon, Fabio Rigat, Hugh E Montgomery, Monty G Mythen and Michael PW Grocott

    Citation: BMC Medical Research Methodology 2010 10:98

    Content type: Research article

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  39. When a patient experiences an event other than the one of interest in the study, usually the probability of experiencing the event of interest is altered. By contrast, disease-free survival time analysis by st...

    Authors: Hyun J Lim, Xu Zhang, Roland Dyck and Nathaniel Osgood

    Citation: BMC Medical Research Methodology 2010 10:97

    Content type: Research article

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  40. Hitherto, risk prediction models for preoperative ultrasound-based diagnosis of ovarian tumors were dichotomous (benign versus malignant). We develop and validate polytomous models (models that predict more th...

    Authors: Ben Van Calster, Lil Valentin, Caroline Van Holsbeke, Antonia C Testa, Tom Bourne, Sabine Van Huffel and Dirk Timmerman

    Citation: BMC Medical Research Methodology 2010 10:96

    Content type: Research article

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  41. Disgust sensitivity is defined as a predisposition to experiencing disgust, which can be measured on the basis of the Disgust Scale and its German version, the Questionnaire for the Assessment of Disgust Sensi...

    Authors: Katja Petrowski, Sören Paul, Gabriele Schmutzer, Marcus Roth, Elmar Brähler and Cornelia Albani

    Citation: BMC Medical Research Methodology 2010 10:95

    Content type: Research article

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  42. US military engagements have consistently raised concern over the array of health outcomes experienced by service members postdeployment. Exploratory factor analysis has been used in studies of 1991 Gulf War-r...

    Authors: Molly L Kelton, Cynthia A LeardMann, Besa Smith, Edward J Boyko, Tomoko I Hooper, Gary D Gackstetter, Paul D Bliese, Charles W Hoge and Tyler C Smith

    Citation: BMC Medical Research Methodology 2010 10:94

    Content type: Research article

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  43. The smallest difference to be detected in superiority trials or the largest difference to be ruled out in noninferiority trials is a key determinant of sample size, but little guidance exists to help researche...

    Authors: Angèle Gayet-Ageron, Thomas Agoritsas, Christophe Combescure, Krisztina Bagamery, Delphine S Courvoisier and Thomas V Perneger

    Citation: BMC Medical Research Methodology 2010 10:93

    Content type: Research article

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  44. The Bielefeld Partnership Expectations Questionnaire (BFPE) is a tool to assess attachment in the romantic relationships of adults. The attachment styles are operationalized as configuration patterns of scale ...

    Authors: Katja Petrowski, Hendrik Berth, Sören Paul, Gesine Grande, Yve Stöbel-Richter and Elmar Brähler

    Citation: BMC Medical Research Methodology 2010 10:92

    Content type: Research article

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  45. Data entry errors are common in clinical research databases. Omitted data are of particular concern because they are more common than erroneously inserted data and therefore could potentially affect research f...

    Authors: Saveli I Goldberg, Andrzej Niemierko, Maria Shubina and Alexander Turchin

    Citation: BMC Medical Research Methodology 2010 10:91

    Content type: Research article

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