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  1. Content type: Research article

    In the era of evidence based medicine, with systematic reviews as its cornerstone, adequate quality assessment tools should be available. There is currently a lack of a systematically developed and evaluated t...

    Authors: Penny Whiting, Anne WS Rutjes, Johannes B Reitsma, Patrick MM Bossuyt and Jos Kleijnen

    Citation: BMC Medical Research Methodology 2003 3:25

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  2. Content type: Study protocol

    Public health research involving social or kin groups (such as sexual partners or family members), rather than samples of unrelated individuals, has become more widespread in response to social ecological appr...

    Authors: James M McMahon, Stephanie Tortu, Leilani Torres, Enrique R Pouget and Rahul Hamid

    Citation: BMC Medical Research Methodology 2003 3:24

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  3. Content type: Research article

    Cross-sectional studies with binary outcomes analyzed by logistic regression are frequent in the epidemiological literature. However, the odds ratio can importantly overestimate the prevalence ratio, the measu...

    Authors: Aluísio JD Barros and Vânia N Hirakata

    Citation: BMC Medical Research Methodology 2003 3:21

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  4. Content type: Debate

    While the desirability of interdisciplinary inquiry has been widely acknowledged, indeed has become 'the mantra of science policy', the methods of interdisciplinary collaboration are opaque to outsiders and gener...

    Authors: David W Robertson, Douglas K Martin and Peter A Singer

    Citation: BMC Medical Research Methodology 2003 3:20

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  5. Content type: Research article

    The aim of this article is to explore ways in which selection bias and ascertainment bias can be reduced and investigated in trials, by using the example of a drug trial carried out in both developed and devel...

    Authors: Gilda Piaggio, Diana Elbourne, Kenneth F Schulz, José Villar, Alain PY Pinol and A Metin Gülmezoglu

    Citation: BMC Medical Research Methodology 2003 3:19

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  6. Content type: Research article

    The Anglia Menorrhagia Education Study (AMES) is a randomized controlled trial testing the effectiveness of an education package applied to general practices. Binary data are available from two sources; genera...

    Authors: Richard M Nixon, Stephen W Duffy and Guy RK Fender

    Citation: BMC Medical Research Methodology 2003 3:17

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  7. Content type: Research article

    There is common belief among some medical researchers that if a potential surrogate endpoint is highly correlated with a true endpoint, then a positive (or negative) difference in potential surrogate endpoints...

    Authors: Stuart G Baker and Barnett S Kramer

    Citation: BMC Medical Research Methodology 2003 3:16

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  8. Content type: Debate

    The electronic version of the British Medical Journal (eBMJ) has a unique feature in that it provides an electronic record of the number of times an article has been viewed ("hits") in the week after its publi...

    Authors: Yoon K Loke and Sheena Derry

    Citation: BMC Medical Research Methodology 2003 3:14

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  9. Content type: Research article

    As an increasingly large number of meta-analyses are published, quantitative methods are needed to help clinicians and systematic review teams determine when meta-analyses are not up to date.

    Authors: Nicholas J Barrowman, Manchun Fang, Margaret Sampson and David Moher

    Citation: BMC Medical Research Methodology 2003 3:13

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  10. Content type: Research article

    It has been estimated that about 45% of abstracts that are accepted for presentation at biomedical meetings will subsequently be published in full. The acceptance of abstracts at meetings and their fate after ...

    Authors: Erik von Elm, Michael C Costanza, Bernhard Walder and Martin R Tramèr

    Citation: BMC Medical Research Methodology 2003 3:12

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  11. Content type: Research article

    When evaluating cancer screening it is important to estimate the cumulative risk of false positives from periodic screening. Because the data typically come from studies in which the number of screenings varie...

    Authors: Stuart G Baker, Diane Erwin and Barnett S Kramer

    Citation: BMC Medical Research Methodology 2003 3:11

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  12. Content type: Debate

    All quantifications of mortality, morbidity, and other health measures involve numerous sources of error. The routine quantification of random sampling error makes it easy to forget that other sources of error...

    Authors: Carl V Phillips and Luwanna M LaPole

    Citation: BMC Medical Research Methodology 2003 3:9

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  13. Content type: Research article

    Many randomized trials involve missing binary outcomes. Although many previous adjustments for missing binary outcomes have been proposed, none of these makes explicit use of randomization to bound the bias wh...

    Authors: Stuart G Baker and Laurence S Freedman

    Citation: BMC Medical Research Methodology 2003 3:8

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    The Erratum to this article has been published in BMC Medical Research Methodology 2004 4:1

  14. Content type: Debate

    Randomised controlled clinical trials are performed to resolve uncertainty concerning comparator interventions. Appropriate acknowledgment of uncertainty enables the concurrent achievement of two goals : the a...

    Authors: Howard Mann and Benjamin Djulbegovic

    Citation: BMC Medical Research Methodology 2003 3:7

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  15. Content type: Research article

    Phase II cancer studies are undertaken to assess the activity of a new drug or a new treatment regimen. Activity is sometimes defined in terms of a survival probability, a binary outcome such as one-year survi...

    Authors: L Douglas Case and Timothy M Morgan

    Citation: BMC Medical Research Methodology 2003 3:6

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  16. Content type: Research article

    The Bayesian approach is one alternative for estimating correlation coefficients in which knowledge from previous studies is incorporated to improve estimation. The purpose of this paper is to illustrate the u...

    Authors: Enrique F Schisterman, Kirsten B Moysich, Lucinda J England and Malla Rao

    Citation: BMC Medical Research Methodology 2003 3:5

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  17. Content type: Research article

    Because randomized cancer screening trials are very expensive, observational cancer screening studies can play an important role in the early phases of screening evaluation. Periodic screening evaluation (PSE)...

    Authors: Stuart G Baker, Diane Erwin, Barnett S Kramer and Philip C Prorok

    Citation: BMC Medical Research Methodology 2003 3:4

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  18. Content type: Research article

    Little work has been done to investigate the suggestion that the use of selected scales from a multi-scale health-status questionnaire would compromise reliability and validity. The aim of this study was to co...

    Authors: Christina Gummesson, Isam Atroshi and Charlotte Ekdahl

    Citation: BMC Medical Research Methodology 2003 3:3

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  19. Content type: Research article

    The evaluation of abstracts for scientific meetings has been shown to suffer from poor inter observer reliability. A measure was developed to assess the formal quality of abstract submissions in a standardized...

    Authors: Antje Timmer, Lloyd R Sutherland and Robert J Hilsden

    Citation: BMC Medical Research Methodology 2003 3:2

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  20. Content type: Research article

    Longitudinal studies with binary repeated outcomes are now widespread in epidemiology. The statistical analysis of these studies presents difficulties and standard methods are inadequate.

    Authors: Isabelle Carrière and Jean Bouyer

    Citation: BMC Medical Research Methodology 2002 2:15

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  21. Content type: Research article

    If intervention A bests B in one randomized trial, and B bests C in another randomized trial, can one conclude that A is better than C? The problem was motivated by the planning of a randomized trial, where A ...

    Authors: Stuart G Baker and Barnett S Kramer

    Citation: BMC Medical Research Methodology 2002 2:13

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    The Erratum to this article has been published in BMC Medical Research Methodology 2003 3:23

  22. Content type: Research article

    The evaluation of randomized trials for cancer screening involves special statistical considerations not found in therapeutic trials. Although some of these issues have been discussed previously, we present im...

    Authors: Stuart G Baker, Barnett S Kramer and Philip C Prorok

    Citation: BMC Medical Research Methodology 2002 2:11

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  23. Content type: Research article

    Meta-analysis is often considered to be a simple way to summarize the existing literature. In this paper we describe how a meta-analysis resembles a conventional study, requiring a written protocol with design...

    Authors: Nancy G Berman and Robert A Parker

    Citation: BMC Medical Research Methodology 2002 2:10

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  24. Content type: Research article

    Although guidelines for critical appraisal of diagnostic research and meta-analyses have already been published, these may be difficult to understand for clinical researchers or do not provide enough detailed ...

    Authors: Walter L Devillé, Frank Buntinx, Lex M Bouter, Victor M Montori, Henrica CW de Vet, Danielle AWM van der Windt and P Dick Bezemer

    Citation: BMC Medical Research Methodology 2002 2:9

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  25. Content type: Debate

    Readers may question the interpretation of findings in clinical trials when multiple outcome measures are used without adjustment of the p-value. This question arises because of the increased risk of Type I er...

    Authors: Ronald J Feise

    Citation: BMC Medical Research Methodology 2002 2:8

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  26. Content type: Research article

    Language bias is a form of publication bias and constitutes a serious threat to meta-analyses. The Cochrane Controlled Trials Register is one attempt to remedy this and now contains more than 300,000 citations...

    Authors: Toshi A Furukawa, Toshiya Inada, Clive E Adams, Hugh McGuire, Ataru Inagaki and Shoko Nozaki

    Citation: BMC Medical Research Methodology 2002 2:6

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  27. Content type: Debate

    The study of cost-effectiveness comparisons between competing medical interventions has led to a variety of proposals for quantifying cost-effectiveness. The differences between the various approaches can be s...

    Authors: Anthony O'Hagan and John W Stevens

    Citation: BMC Medical Research Methodology 2002 2:5

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  28. Content type: Research article

    Recently many long-term prospective studies have involved serial collection and storage of blood or tissue specimens. This has spurred nested case-control studies that involve testing some specimens for variou...

    Authors: Stuart G Baker, Barnett S Kramer and Sudhir Srivastava

    Citation: BMC Medical Research Methodology 2002 2:4

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  29. Content type: Debate

    To consider the problem of the calculation of number needed to treat (NNT) derived from risk difference, odds ratio, and raw pooled events shown to give different results using data from a review of nursing in...

    Authors: R Andrew Moore, David J Gavaghan, Jayne E Edwards, Phillip Wiffen and Henry J McQuay

    Citation: BMC Medical Research Methodology 2002 2:2

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  30. Content type: Research article

    The Digestive Diseases Week (DDW) is the major meeting for presentation of research in gastroenterology. The acceptance of an abstract for presentation at this meeting is the most important determinant of subs...

    Authors: Antje Timmer, Robert J Hilsden and Lloyd R Sutherland

    Citation: BMC Medical Research Methodology 2001 1:13

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  31. Content type: Research article

    Response rates to surveys are declining and this threatens the validity and generalisability of their findings. We wanted to determine whether paper quality influences the response rate to postal surveys

    Authors: T Justin Clark, Khalid S Khan and Janesh K Gupta

    Citation: BMC Medical Research Methodology 2001 1:12

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  32. Content type: Research article

    Published formulas for case-control designs provide sample sizes required to determine that a given disease-exposure odds ratio is significantly different from one, adjusting for a potential confounder and pos...

    Authors: Michael D Edwardes

    Citation: BMC Medical Research Methodology 2001 1:11

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  33. Content type: Research article

    Although a randomized trial represents the most rigorous method of evaluating a medical intervention, some interventions would be extremely difficult to evaluate using this study design. One alternative, an ob...

    Authors: Stuart G Baker, Karen S Lindeman and Barnett S Kramer

    Citation: BMC Medical Research Methodology 2001 1:9

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  34. Content type: Research article

    We would expect information on adverse drug reactions in randomised clinical trials to be easily retrievable from specific searches of electronic databases. However, complete retrieval of such information may ...

    Authors: Sheena Derry, Yoon Kong Loke and Jeffrey K Aronson

    Citation: BMC Medical Research Methodology 2001 1:7

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  35. Content type: Research article

    Many randomized trials involve measuring a continuous outcome - such as pain, body weight or blood pressure - at baseline and after treatment. In this paper, I compare four possibilities for how such trials ca...

    Authors: Andrew J Vickers

    Citation: BMC Medical Research Methodology 2001 1:6

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