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  1. Multiple regression models are used in a wide range of scientific disciplines and automated model selection procedures are frequently used to identify independent predictors. However, determination of relative...

    Authors: Joseph Beyene, Eshetu G Atenafu, Jemila S Hamid, Teresa To and Lillian Sung
    Citation: BMC Medical Research Methodology 2009 9:64
    Content type: Research article Published on:

  2. Epidemiological and clinical studies, often including anthropometric measures, have established obesity as a major risk factor for the development of type 2 diabetes. Appropriate cut-off values for anthropomet...

    Authors: Jens Klotsche, Dietmar Ferger, Lars Pieper, Jürgen Rehm and Hans-Ulrich Wittchen
    Citation: BMC Medical Research Methodology 2009 9:63
    Content type: Research article Published on:

  3. Accurate estimates of incidence and prevalence of the disease is a vital step toward appropriate interventions for chronic disease like diabetes. A growing body of scientific literature is now available on pro...

    Authors: Shabnam Asghari, Josiane Courteau, André C Carpentier and Alain Vanasse
    Citation: BMC Medical Research Methodology 2009 9:62
    Content type: Research article Published on:

  4. This article describes the challenges a research team experienced recruiting physicians within a randomised controlled trial about leg ulcer care that seeks to foster the cooperation between the medical and nu...

    Authors: Oliver R Herber, Wilfried Schnepp and Monika A Rieger
    Citation: BMC Medical Research Methodology 2009 9:61
    Content type: Research article Published on:

  5. Aboriginal Australians experience poorer outcomes, and are 2.5 times more likely to die from cancer than non-Aboriginal people, even after adjustment for stage of diagnosis, cancer treatment and comorbidities....

    Authors: Shaouli Shahid, Dawn Bessarab, Peter Howat and Sandra C Thompson
    Citation: BMC Medical Research Methodology 2009 9:60
    Content type: Correspondence Published on:

  7. Accurate measures of physical activity are highly needed. We evaluated the test-retest reliability and construct validity of the self-report Activity Questionnaire for Adults and Adolescents (AQuAA). The AQuAA...

    Authors: Mai JM Chinapaw, Sander M Slootmaker, Albertine J Schuit, Mariska van Zuidam and Willem van Mechelen
    Citation: BMC Medical Research Methodology 2009 9:58
    Content type: Research article Published on:

  8. Multiple imputation (MI) provides an effective approach to handle missing covariate data within prognostic modelling studies, as it can properly account for the missing data uncertainty. The multiply imputed d...

    Authors: Andrea Marshall, Douglas G Altman, Roger L Holder and Patrick Royston
    Citation: BMC Medical Research Methodology 2009 9:57
    Content type: Research article Published on:

  11. Innovations to be deployed during consultations with patients may influence the clinical performance of the medical practitioner. This study examined the impact on General Practitioners' (GPs) consultation per...

    Authors: Moyez Jiwa, Robert K McKinley, Katrina Spilsbury, Hayley Arnet and Marthe Smith
    Citation: BMC Medical Research Methodology 2009 9:54
    Content type: Research article Published on:

  12. Rankings based on outcome are often used to present health care provider performance. These rankings do however not reflect that part of the variation in outcome between providers is caused by natural variatio...

    Authors: Hester F Lingsma, Marinus JC Eijkemans and Ewout W Steyerberg
    Citation: BMC Medical Research Methodology 2009 9:53
    Content type: Research article Published on:

  14. Community-based recruitment is challenging particularly if the sampling frame is not easily defined as in the case of people who drink rainwater. Strategies for contacting participants must be carefully consid...

    Authors: Shelly Rodrigo, Martha Sinclair, David Cunliffe and Karin Leder
    Citation: BMC Medical Research Methodology 2009 9:51
    Content type: Research article Published on:

  15. Observational outcome studies of patients with obstructive sleep apnea (OSA) require adjustment for co-morbidity to produce valid results. The aim of this study was to evaluate whether the combination of admin...

    Authors: Paul E Ronksley, Willis H Tsai, Hude Quan, Peter Faris and Brenda R Hemmelgarn
    Citation: BMC Medical Research Methodology 2009 9:50
    Content type: Research article Published on:

  17. Linking population health data to pathology data is a new approach for the evaluation of predictive tests that is potentially more efficient, feasible and efficacious than current methods. Studies evaluating t...

    Authors: Samantha J Lain, Charles S Algert, Vitomir Tasevski, Jonathan M Morris and Christine L Roberts
    Citation: BMC Medical Research Methodology 2009 9:48
    Content type: Research article Published on:

  19. Response rates in surveys have been falling over the last 20 years, leading to the need for novel approaches to enhance recruitment. This study describes strategies used to maximise recruitment to a home inter...

    Authors: Kirsty Kiezebrink, Iain K Crombie, Linda Irvine, Vivien Swanson, Kevin Power, Wendy L Wrieden and Peter W Slane
    Citation: BMC Medical Research Methodology 2009 9:46
    Content type: Research article Published on:

  20. Self-reported data are a common source of information about drug exposure. Modes of data collection differ considerably and the questionnaire's structure may affect prevalence estimates. We compared the recall...

    Authors: Helena Gama, Sofia Correia and Nuno Lunet
    Citation: BMC Medical Research Methodology 2009 9:45
    Content type: Research article Published on:

  21. Lower-than-expected incidence of HIV undermines sample size calculations and compromises the power of a HIV prevention trial. We evaluated the effectiveness of interim monitoring of HIV infection rates and on-...

    Authors: Vera Halpern, Orikomaba Obunge, Folasade Ogunsola, Sakiru Otusanya, John Umo-Otong, Chin-Hua Wang and Neha Mehta
    Citation: BMC Medical Research Methodology 2009 9:44
    Content type: Research article Published on:

  22. The timing of prophylactic antibiotic administration is a patient safety outcome that is recurrently tracked and reported. The interpretation of these data has important implications for patient safety practic...

    Authors: Carrie Cartmill, Lorelei Lingard, Glenn Regehr, Sherry Espin, John Bohnen, Ross Baker and Lorne Rotstein
    Citation: BMC Medical Research Methodology 2009 9:43
    Content type: Correspondence Published on:

  23. Studies of cancer incidence and early management will increasingly draw on routine electronic patient records. However, data may be incomplete or inaccurate. We developed a generalisable strategy for investiga...

    Authors: A Rosemary Tate, Alexander GR Martin, Tarita Murray-Thomas, Sarah R Anderson and Jackie A Cassell
    Citation: BMC Medical Research Methodology 2009 9:42
    Content type: Research article Published on:

  24. Assumptions underlying placebo controlled trials include that the placebo effect impacts on all study arms equally, and that treatment effects are additional to the placebo effect. However, these assumptions h...

    Authors: M Diana van Die, Kerry M Bone, Henry G Burger and Helena J Teede
    Citation: BMC Medical Research Methodology 2009 9:41
    Content type: Research article Published on:

  25. Recruitment and retention of patients and healthcare providers in randomised controlled trials (RCTs) is important in order to determine the effectiveness of interventions. However, failure to achieve recruitm...

    Authors: Claire S Leathem, Margaret E Cupples, Mary C Byrne, Mary O'Malley, Ailish Houlihan, Andrew W Murphy and Susan M Smith
    Citation: BMC Medical Research Methodology 2009 9:40
    Content type: Research article Published on:

  26. In a multicenter trial, responses for subjects belonging to a common center are correlated. Such a clustering is usually assessed through the design effect, defined as a ratio of two variances. The aim of this...

    Authors: Emilie Vierron and Bruno Giraudeau
    Citation: BMC Medical Research Methodology 2009 9:39
    Content type: Research article Published on:

  27. The gathering of feedback on doctors from patients after consultations is an important part of patient involvement and participation. This study first assesses the 23-item Patient Feedback Questionnaire (PFQ) ...

    Authors: Tsair-Wei Chien, Weng-Chung Wang, Sho-Be Lin, Ching-Yih Lin, How-Ran Guo and Shih-Bin Su
    Citation: BMC Medical Research Methodology 2009 9:38
    Content type: Research article Published on:

  28. Cluster randomized trials (CRTs) are increasingly used to assess the effectiveness of interventions to improve health outcomes or prevent diseases. However, the efficiency and consistency of using different an...

    Authors: Jinhui Ma, Lehana Thabane, Janusz Kaczorowski, Larry Chambers, Lisa Dolovich, Tina Karwalajtys and Cheryl Levitt
    Citation: BMC Medical Research Methodology 2009 9:37
    Content type: Research article Published on:

  29. In the last decade mobile telephone use has become more widespread among children. Concerns expressed about possible health risks have led to epidemiological studies investigating adverse health outcomes assoc...

    Authors: Imo Inyang, Geza Benke, Joseph Morrissey, Ray McKenzie and Michael Abramson
    Citation: BMC Medical Research Methodology 2009 9:36
    Content type: Research article Published on:

  30. Reporting numbers needed to treat (NNT) improves interpretability of trial results. It is unusual that continuous outcomes are converted to numbers of individual responders to treatment (i.e., those who reach ...

    Authors: Robert Froud, Sandra Eldridge, Ranjit Lall and Martin Underwood
    Citation: BMC Medical Research Methodology 2009 9:35
    Content type: Research article Published on:

  31. In 1999 a four-level hierarchy of evidence was promoted by the National Health and Medical Research Council in Australia. The primary purpose of this hierarchy was to assist with clinical practice guideline de...

    Authors: Tracy Merlin, Adele Weston and Rebecca Tooher
    Citation: BMC Medical Research Methodology 2009 9:34
    Content type: Research article Published on:

  33. It is often desirable to observe how a disease progresses over time in individual patients, rather than graphing group averages; and since multiple outcomes are typically recorded on each patient, it would be ...

    Authors: Stanley E Lazic, Sarah L Mason, Andrew W Michell and Roger A Barker
    Citation: BMC Medical Research Methodology 2009 9:32
    Content type: Research article Published on:

  34. Discrete choice experiments (DCEs) allow systematic assessment of preferences by asking respondents to choose between scenarios. We conducted a labelled discrete choice experiment with realistic choices to inv...

    Authors: Michelle E Kruijshaar, Marie-Louise Essink-Bot, Bas Donkers, Caspar WN Looman, Peter D Siersema and Ewout W Steyerberg
    Citation: BMC Medical Research Methodology 2009 9:31
    Content type: Research article Published on:

  35. The problem of silent multiple comparisons is one of the most difficult statistical problems faced by scientists. It is a particular problem for investigating a one-off cancer cluster reported to a health depa...

    Authors: Michael D Coory, Rachael A Wills and Adrian G Barnett
    Citation: BMC Medical Research Methodology 2009 9:30
    Content type: Research article Published on:

  36. Systematic review and meta-analysis currently underpin much of evidence-based medicine. Such methodologies bring order to previous research, but future research planning remains relatively incoherent and ineffici...

    Authors: Alexander J Sutton, Nicola J Cooper and David R Jones
    Citation: BMC Medical Research Methodology 2009 9:29
    Content type: Research article Published on:

  37. Health-related quality of life is a topic of current interest. This paper considers a randomized phase III study of radiation therapy with concurrent chemotherapy (docetaxel) versus radiation therapy alone in ...

    Authors: Nina Gunnes, Taral G Seierstad, Steinar Aamdal, Paal F Brunsvig, Anne-Birgitte Jacobsen, Stein Sundstrøm and Odd O Aalen
    Citation: BMC Medical Research Methodology 2009 9:28
    Content type: Research article Published on:

  38. Physical activity is being studied as a breast cancer prevention strategy. Women at risk of breast cancer report interest in lifestyle modification, but recruitment to randomized physical activity intervention...

    Authors: Larissa A Korde, Amy Micheli, Ashley W Smith, David Venzon, Sheila A Prindiville, Bart Drinkard, Nancy Sebring, Marcia D Smith, Jo Anne Zujewski and Jennifer Eng-Wong
    Citation: BMC Medical Research Methodology 2009 9:27
    Content type: Research article Published on:

  40. Many recently published clinical studies report sex-specific data. This information may help to improve clinical decision-making for both sexes, but it is not easily accessible in MEDLINE. The aim of this proj...

    Authors: Clara J Moerman, Rikie Deurenberg and Joke A Haafkens
    Citation: BMC Medical Research Methodology 2009 9:25
    Content type: Research article Published on:

  41. Stents are commonly used to treat patients with coronary artery disease. However, the quality of reporting internal and external validity data in published reports of randomised controlled trials (RCTs) of ste...

    Authors: Morgane Ethgen, lsabelle Boutron, Philippe Gabriel Steg, Carine Roy and Philippe Ravaud
    Citation: BMC Medical Research Methodology 2009 9:24
    Content type: Research article Published on:

  42. Data from scientific literature show that about 63% of abstracts presented at biomedical conferences will be published in full. Some studies have indicated that full publication is associated with the directio...

    Authors: Simona Vecchi, Valeria Belleudi, Laura Amato, Marina Davoli and Carlo A Perucci
    Citation: BMC Medical Research Methodology 2009 9:23
    Content type: Correspondence Published on:

  43. In clinical practice a diagnosis is based on a combination of clinical history, physical examination and additional diagnostic tests. At present, studies on diagnostic research often report the accuracy of tes...

    Authors: Kimiko A Broeze, Brent C Opmeer, Lucas M Bachmann, Frank J Broekmans, Patrick MM Bossuyt, Sjors FPJ Coppus, Neil P Johnson, Khalid S Khan, Gerben ter Riet, Fulco van der Veen, Madelon van Wely and Ben WJ Mol
    Citation: BMC Medical Research Methodology 2009 9:22
    Content type: Study protocol Published on:

  45. Latinos comprise the largest racial/ethnic group in the United States and have 2–3 times the prevalence of type 2 diabetes mellitus as Caucasians.

    Authors: Philip A Merriam, Trinidad L Tellez, Milagros C Rosal, Barbara C Olendzki, Yunsheng Ma, Sherry L Pagoto and Ira S Ockene
    Citation: BMC Medical Research Methodology 2009 9:20
    Content type: Study protocol Published on:

  46. Understanding participation in a prospective study is crucial to maintaining and improving retention rates. In 1990–92, following attempted blood donation at five blood centers, we enrolled 155 HTLV-I, 387 HTL...

    Authors: Deborah A DeVita, Mary C White, Xin Zhao, Zhanna Kaidarova and Edward L Murphy
    Citation: BMC Medical Research Methodology 2009 9:19
    Content type: Research article Published on:

  48. Parental rearing behavior is a significant etiological factor for the vulnerability of psychopathology and has been an issue of clinical research for a long time. For this scope instruments are important who a...

    Authors: Katja Petrowski, Hendrik Berth, Silke Schmidt, Jörg Schumacher, Andreas Hinz and Elmar Brähler
    Citation: BMC Medical Research Methodology 2009 9:17
    Content type: Research article Published on:

  49. Systematic reviews have developed into a powerful method for summarising and synthesising evidence. The rise in systematic reviews creates a methodological opportunity and associated challenges and this is see...

    Authors: Rebecca E Ryan, Caroline A Kaufman and Sophie J Hill
    Citation: BMC Medical Research Methodology 2009 9:16
    Content type: Correspondence Published on:

  50. The purpose of this article is to describe and evaluate the methodology of online focus group discussions within the setting of paediatric oncology.

    Authors: Kiek Tates, Marieke Zwaanswijk, Roel Otten, Sandra van Dulmen, Peter M Hoogerbrugge, Willem A Kamps and Jozien M Bensing
    Citation: BMC Medical Research Methodology 2009 9:15
    Content type: Research article Published on:
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BMC Medical Research Methodology

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