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  1. A lack of available data and statistical code being published alongside journal articles provides a significant barrier to open scientific discourse, and reproducibility of research. Information governance res...

    Authors: Aiden Smith, Paul C. Lambert and Mark J. Rutherford
    Citation: BMC Medical Research Methodology 2022 22:176
  2. Normalization process theory (NPT) has been widely used to better understand how new interventions are implemented and embedded. The NoMAD (Normalization Measurement Development questionnaire) is a 23-item NPT...

    Authors: Larkin Lamarche, Rebecca E. Clark, Fiona Parascandalo and Dee Mangin
    Citation: BMC Medical Research Methodology 2022 22:175
  3. Sustainable Human Immunodeficiency Virus (HIV) virological suppression is crucial to achieving the Joint United Nations Programme of HIV/AIDS (UNAIDS) 95–95-95 treatment targets to reduce the risk of onward HI...

    Authors: Adenike O. Soogun, Ayesha B. M. Kharsany, Temesgen Zewotir, Delia North and Ropo Ebenezer Ogunsakin
    Citation: BMC Medical Research Methodology 2022 22:174
  4. The concept of standard of care (SoC) treatment is commonly utilized in clinical trials. However, in a setting of an emergent disease, such as COVID-19, where there is no established effective treatment, it is...

    Authors: Mahir Fidahic, Danijela Nujic, Marta Civljak, Renata Runjic, Filipa Markotic, Marin Vidak and Livia Puljak
    Citation: BMC Medical Research Methodology 2022 22:173
  5. The NINDS rt-PA Stroke Study is frequently cited in support of alteplase for acute ischemic stroke within 3 h of symptom onset. Multiple post-hoc reanalyses of this trial have been published to adjust for a ba...

    Authors: Ravi Garg and Steffen Mickenautsch
    Citation: BMC Medical Research Methodology 2022 22:172
  6. To summarize the up-to-date empirical evidence on trial-level characteristics of randomized controlled trials associated with treatment effect estimates.

    Authors: Huan Wang, Jinlu Song, Yali Lin, Wenjie Dai, Yinyan Gao, Lang Qin, Yancong Chen, Wilson Tam, Irene XY Wu and Vincent CH Chung
    Citation: BMC Medical Research Methodology 2022 22:171
  7. Schizophrenia is a chronic, severe, and debilitating mental disorder always considered one of the recurrent psychiatric diseases. This study aimed to use penalized count regression models to determine factors ...

    Authors: Mahya Arayeshgari, Ghodratollah Roshanaei, Ali Ghaleiha, Jalal Poorolajal and Leili Tapak
    Citation: BMC Medical Research Methodology 2022 22:170
  8. In binary logistic regression data are ‘separable’ if there exists a linear combination of explanatory variables which perfectly predicts the observed outcome, leading to non-existence of some of the maximum l...

    Authors: Angelika Geroldinger, Rok Blagus, Helen Ogden and Georg Heinze
    Citation: BMC Medical Research Methodology 2022 22:168
  9. Machine learning and automation are increasingly used to make the evidence synthesis process faster and more responsive to policymakers’ needs. In systematic reviews of randomized controlled trials (RCTs), ris...

    Authors: Patricia Sofia Jacobsen Jardim, Christopher James Rose, Heather Melanie Ames, Jose Francisco Meneses Echavez, Stijn Van de Velde and Ashley Elizabeth Muller
    Citation: BMC Medical Research Methodology 2022 22:167
  10. Real-life data consist of exhaustive data which are not subject to selection bias. These data enable to study drug-safety profiles but are underused because of their temporality, necessitating complex models (...

    Authors: P. Sabatier, M. Wack, J. Pouchot, N. Danchin and AS. Jannot
    Citation: BMC Medical Research Methodology 2022 22:166
  11. Network analysis, a technique for describing relationships, can provide insights into patterns of co-occurring chronic health conditions. The effect that co-occurrence measurement has on disease network struct...

    Authors: Barret A. Monchka, Carson K. Leung, Nathan C. Nickel and Lisa M. Lix
    Citation: BMC Medical Research Methodology 2022 22:165
  12. There is increasing interest in the development and use of clinical prediction models, but a lack of evidence-supported guidance on the merits of different modelling approaches. This is especially true for tim...

    Authors: Alana R. Cuthbert, Lynne C. Giles, Gary Glonek, Lisa M. Kalisch Ellett and Nicole L. Pratt
    Citation: BMC Medical Research Methodology 2022 22:164
  13. Development of complex interventions for management of chronic conditions has become increasingly common, with guidance now provided. Fidelity (whether the intervention is designed, delivered and received as i...

    Authors: Steed L., Wileman V., Sohanpal R., Kelly MJ., Pinnock H. and Taylor SJC
    Citation: BMC Medical Research Methodology 2022 22:163
  14. Recent international health events have led to an increased proliferation of remotely delivered health interventions. Even with the pandemic seemingly coming under control, the experiences of the past year hav...

    Authors: Daniel I. Rhon, Julie M. Fritz, Robert D. Kerns, Donald D. McGeary, Brian C. Coleman, Shawn Farrokhi, Diana J. Burgess, Christine M. Goertz, Stephanie L. Taylor and Tammy Hoffmann
    Citation: BMC Medical Research Methodology 2022 22:161
  15. To evaluate the performance of the automated abstract screening tool Rayyan.

    Authors: Amir Valizadeh, Mana Moassefi, Amin Nakhostin-Ansari, Seyed Hossein Hosseini Asl, Mehrnush Saghab Torbati, Reyhaneh Aghajani, Zahra Maleki Ghorbani and Shahriar Faghani
    Citation: BMC Medical Research Methodology 2022 22:160
  16. Accurate and reliable estimates of violence against women form the backbone of global and regional monitoring efforts to eliminate this human right violation and public health problem. Estimating the prevalenc...

    Authors: Mathieu Maheu-Giroux, Lynnmarie Sardinha, Heidi Stöckl, Sarah R. Meyer, Arnaud Godin, Monica Alexander and Claudia García-Moreno
    Citation: BMC Medical Research Methodology 2022 22:159
  17. Preconception pregnancy risk profiles—characterizing the likelihood that a pregnancy attempt results in a full-term birth, preterm birth, clinical pregnancy loss, or failure to conceive—can provide critical in...

    Authors: Kaitlyn Cook, Neil J. Perkins, Enrique Schisterman and Sebastien Haneuse
    Citation: BMC Medical Research Methodology 2022 22:156
  18. Natalizumab and fingolimod are used as high-efficacy treatments in relapsing–remitting multiple sclerosis. Several observational studies comparing these two drugs have shown variable results, using different m...

    Authors: M. Lefort, S. Sharmin, J. B. Andersen, S. Vukusic, R. Casey, M. Debouverie, G. Edan, J. Ciron, A. Ruet, J. De Sèze, E. Maillart, H. Zephir, P. Labauge, G. Defer, C. Lebrun-Frenay, T. Moreau…
    Citation: BMC Medical Research Methodology 2022 22:155
  19. This study evaluated the adequacy of randomization in randomized controlled trials by investigating baseline differences in the primary outcome when a meta-analysis employed an outcome whose baseline level was...

    Authors: Eun-Gee Park and Seokyung Hahn
    Citation: BMC Medical Research Methodology 2022 22:154
  20. As the cost of RNA-sequencing decreases, complex study designs, including paired, longitudinal, and other correlated designs, become increasingly feasible. These studies often include multiple hypotheses and t...

    Authors: Elizabeth A. Wynn, Brian E. Vestal, Tasha E. Fingerlin and Camille M. Moore
    Citation: BMC Medical Research Methodology 2022 22:153
  21. Observational data are increasingly being used to conduct external comparisons to clinical trials. In this study, we empirically examined whether different methodological approaches to longitudinal missing dat...

    Authors: Vibeke Norvang, Espen A. Haavardsholm, Sara K. Tedeschi, Houchen Lyu, Joseph Sexton, Maria D. Mjaavatten, Tore K. Kvien, Daniel H. Solomon and Kazuki Yoshida
    Citation: BMC Medical Research Methodology 2022 22:152
  22. Middle-aged and older adults are more likely to suffer from chronic diseases because of their particular health characteristics, which lead to a high incidence of catastrophic health expenditure (CHE). This st...

    Authors: Wenqing Miao, Xiyu Zhang, Baoguo Shi, Wanxin Tian, Bing Wu, Yongqiang Lai, Yuze Li, Zhipeng Huang, Qi Xia, Huiqi Yang, Fan Ding, Linghan Shan, Ling Xin, Jingying Miao, Chenxi Zhang, Ye Li…
    Citation: BMC Medical Research Methodology 2022 22:151
  23. The major drivers of cost-effectiveness for chronic obstructive pulmonary disease (COPD) therapies are the occurrence of exacerbations and deaths. Exacerbations, including acute and long-term events, can cause...

    Authors: Kirsty Rhodes, Martin Jenkins, Enrico de Nigris, Magnus Aurivillius and Mario Ouwens
    Citation: BMC Medical Research Methodology 2022 22:150
  24. We examine the concept of Bayesian Additional Evidence (BAE) recently proposed by Sondhi et al. We derive simple closed-form expressions for BAE and compare its properties with other methods for assessing find...

    Authors: Samuel Pawel, Leonhard Held and Robert Matthews
    Citation: BMC Medical Research Methodology 2022 22:149
  25. Missing data prove troublesome in data analysis; at best they reduce a study’s statistical power and at worst they induce bias in parameter estimates. Multiple imputation via chained equations is a popular tec...

    Authors: Matthew A. Bolt, Samantha MaWhinney, Jack W. Pattee, Kristine M. Erlandson, David B. Badesch and Ryan A. Peterson
    Citation: BMC Medical Research Methodology 2022 22:148
  26. Accelerometery is commonly used to estimate physical activity, sleep, and sedentary behavior. In free-living conditions, periods of device removal (non-wear) can lead to misclassification of behavior with cons...

    Authors: Adam Vert, Kyle S. Weber, Vanessa Thai, Erin Turner, Kit B. Beyer, Benjamin F Cornish, F. Elizabeth Godkin, Christopher Wong, William E. McIlroy and Karen Van Ooteghem
    Citation: BMC Medical Research Methodology 2022 22:147
  27. Regression models are often used to explain the relative risk of infectious diseases among groups. For example, overrepresentation of immigrants among COVID-19 cases has been found in multiple countries. Sever...

    Authors: Solveig Engebretsen, Gunnar Rø and Birgitte Freiesleben de Blasio
    Citation: BMC Medical Research Methodology 2022 22:146
  28. Epidemiological studies of incidence play an essential role in quantifying disease burden, resource planning, and informing public health policies. A variety of measures for estimating cancer incidence have be...

    Authors: Norah Alsadhan, Alaa Almaiman, Mar Pujades-Rodriguez, Cathy Brennan, Farag Shuweihdi, Sultana A. Alhurishi and Robert M. West
    Citation: BMC Medical Research Methodology 2022 22:144
  29. Cohort collaborations often require meta-analysis of exposure-outcome association estimates across cohorts as an alternative to pooling individual-level data that requires a laborious process of data harmoniza...

    Authors: Debashree Ray, Alvaro Muñoz, Mingyu Zhang, Xiuhong Li, Nilanjan Chatterjee, Lisa P. Jacobson and Bryan Lau
    Citation: BMC Medical Research Methodology 2022 22:143
  30. Whether there is sufficient capacity and capability for the successful conduct and delivery of a clinical trial should be assessed by several stakeholders according to transparent and evidence-based criteria d...

    Authors: Viktoria Gloy, Benjamin Speich, Alexandra Griessbach, Ala Taji Heravi, Alexandra Schulz, Thomas Fabbro, Christiane Pauli Magnus, Stuart McLennan, Wendy Bertram and Matthias Briel
    Citation: BMC Medical Research Methodology 2022 22:142
  31. Screening for eligible patients continues to pose a great challenge for many clinical trials. This has led to a rapidly growing interest in standardizing computable representations of eligibility criteria (EC)...

    Authors: Ahmed Rafee, Sarah Riepenhausen, Philipp Neuhaus, Alexandra Meidt, Martin Dugas and Julian Varghese
    Citation: BMC Medical Research Methodology 2022 22:141
  32. Health surveys are commonly somewhat non-representative of their target population, potentially limiting the generalisability of prevalence estimates for health/behaviour characteristics and disease to the pop...

    Authors: Sarsha Yap, Qingwei Luo, Stephen Wade, Marianne Weber, Emily Banks, Karen Canfell, Dianne L. O’Connell and Julia Steinberg
    Citation: BMC Medical Research Methodology 2022 22:140
  33. Social media has led to fundamental changes in the way that people look for and share health related information. There is increasing interest in using this spontaneously generated patient experience data as a...

    Authors: Julia Walsh, Christine Dwumfour, Jonathan Cave and Frances Griffiths
    Citation: BMC Medical Research Methodology 2022 22:139
  34. Stigmatized behaviours are often underreported, especially in pregnancy, making them challenging to address. The Alcohol and Child Development Study (ACDS) seeks to inform prevention of foetal alcohol harm, li...

    Authors: David Tappin, Daniel Mackay, Lucy Reynolds and Niamh Fitzgerald
    Citation: BMC Medical Research Methodology 2022 22:138
  35. With the spread of COVID-19, the time-series prediction of COVID-19 has become a research hotspot. Unlike previous epidemics, COVID-19 has a new pattern of long-time series, large fluctuations, and multiple pe...

    Authors: Haoran Dai, Wen Cao, Xiaochong Tong, Yunxing Yao, Feilin Peng, Jingwen Zhu and Yuzhen Tian
    Citation: BMC Medical Research Methodology 2022 22:137
  36. Manually extracted data points from health records are collated on an institutional, provincial, and national level to facilitate clinical research. However, the labour-intensive clinical chart review process ...

    Authors: Yifu Chen, Lucy Hao, Vito Z. Zou, Zsuzsanna Hollander, Raymond T. Ng and Kathryn V. Isaac
    Citation: BMC Medical Research Methodology 2022 22:136
  37. Valid and reliable research tools to assess children’s and adolescent’s health-related behaviour are highly needed across the globe. Rapid economic development, globalization, and associated lifestyle challeng...

    Authors: Jaroslav Kohoutek, Marek Maráček, Kwok Ng and Zdenek Hamrik
    Citation: BMC Medical Research Methodology 2022 22:135
  38. Guideline adaptation provides an important alternative to de novo guideline development by making the process more efficient and reducing unnecessary duplication. The quality evaluation of international guidel...

    Authors: Daniela D’angelo, Daniela Coclite, Antonello Napoletano, Silvia Gianola, Greta Castellini, Roberto Latina, Laura Iacorossi, Alice Josephine Fauci and Primiano Iannone
    Citation: BMC Medical Research Methodology 2022 22:134
  39. Prior work has shown that combining bootstrap imputation with tree-based machine learning variable selection methods can provide good performances achievable on fully observed data when covariate and outcome d...

    Authors: Jung-Yi Joyce Lin, Liangyuan Hu, Chuyue Huang, Ji Jiayi, Steven Lawrence and Usha Govindarajulu
    Citation: BMC Medical Research Methodology 2022 22:132
  40. A relative survival approach is often used in population-based cancer studies, where other cause (or expected) mortality is assumed to be the same as the mortality in the general population, given a specific c...

    Authors: Yuliya Leontyeva, Hannah Bower, Oskar Gauffin, Paul C Lambert and Therese M.-L. Andersson
    Citation: BMC Medical Research Methodology 2022 22:130
  41. Many clinical trial procedures were often undertaken in-person prior to the COVID-19 pandemic, which has resulted in adaptations to these procedures to enable trials to continue. The aim of this study was to u...

    Authors: Robin Chatters, Cindy L. Cooper, Alicia O’Cathain, Caroline Murphy, Athene Lane, Katie Sutherland, Christopher Burton, Angela Cape and Louis Tunnicliffe
    Citation: BMC Medical Research Methodology 2022 22:128
  42. The Numerical Rating Scale (NRS) and Patient-rated wrist/hand evaluation (PRWHE) are patient-reported outcomes frequently used for evaluating pain and function of the wrist and hand. The aim of this study was ...

    Authors: Susanna Stjernberg-Salmela, Teemu Karjalainen, Joona Juurakko, Pirjo Toivonen, Eero Waris, Simo Taimela, Clare L. Ardern, Teppo L. N. Järvinen and Jarkko Jokihaara
    Citation: BMC Medical Research Methodology 2022 22:127

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