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BMC Medical Research Methodology


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  1. Content type: Research article

    More patient-specific medical care is expected as more is learned about variations in patient responses to medical treatments. Analytical tools enable insights by linking treatment responses from different typ...

    Authors: Joe Alexander, Roger A. Edwards, Alberto Savoldelli, Luigi Manca, Roberto Grugni, Birol Emir, Ed Whalen, Stephen Watt, Marina Brodsky and Bruce Parsons

    Citation: BMC Medical Research Methodology 2017 17:113

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  2. Content type: Research Article

    In a random effects meta-analysis model, true treatment effects for each study are routinely assumed to follow a normal distribution. However, normality is a restrictive assumption and the misspecification of ...

    Authors: Yusuke Yamaguchi, Kazushi Maruo, Christopher Partlett and Richard D. Riley

    Citation: BMC Medical Research Methodology 2017 17:109

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  3. Content type: Research article

    The application of adaptive design methodology within a clinical trial setting is becoming increasingly popular. However the application of these methods within trials is not being reported as adaptive designs...

    Authors: Pankaj Mistry, Janet A Dunn and Andrea Marshall

    Citation: BMC Medical Research Methodology 2017 17:108

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  4. Content type: Research Article

    Joint models of longitudinal and time-to-event data are increasingly used to perform individual dynamic prediction of a risk of event. However the difficulty to perform inference in nonlinear models and to cal...

    Authors: Solène Desmée, France Mentré, Christine Veyrat-Follet, Bernard Sébastien and Jérémie Guedj

    Citation: BMC Medical Research Methodology 2017 17:105

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  5. Content type: Debate

    The standard definition for protocol adherence is the proportion of all scheduled doses that are delivered. In clinical research, this definition has several limitations when evaluating protocol adherence in t...

    Authors: F. Lauzier, N. K. Adhikari, A. Seely, K. K. Y. Koo, E. P. Belley-Côté, K. E. A. Burns, D. J. Cook, F. D’Aragon, B. Rochwerg, M. E. Kho, S. J. W. Oczkowksi, E. H. Duan, M. O. Meade, A. G. Day and F. Lamontagne

    Citation: BMC Medical Research Methodology 2017 17:106

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  6. Content type: Technical advance

    The sample size required to power a study to a nominal level in a paired comparative diagnostic accuracy study, i.e. studies in which the diagnostic accuracy of two testing procedures is compared relative to a...

    Authors: Gareth P. J. McCray, Andrew C. Titman, Paula Ghaneh and Gillian A. Lancaster

    Citation: BMC Medical Research Methodology 2017 17:102

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  7. Content type: Research article

    Network meta-analysis overcomes the limitations of traditional pair-wise meta-analysis by incorporating all available evidence into a general statistical framework for simultaneous comparisons of several treat...

    Authors: Yu-Kang Tu and Yun-Chun Wu

    Citation: BMC Medical Research Methodology 2017 17:104

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  8. Content type: Research article

    Prognostic models often show poor performance when applied to independent validation data sets. We illustrate how treatment use in a validation set can affect measures of model performance and present the uses...

    Authors: Romin Pajouheshnia, Linda M. Peelen, Karel G. M. Moons, Johannes B. Reitsma and Rolf H. H. Groenwold

    Citation: BMC Medical Research Methodology 2017 17:103

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  9. Content type: Research article

    African Americans have been historically under-represented in genetic studies. More research is needed on effective recruitment strategies for this population, especially on approaches that supplement traditio...

    Authors: Rebecca Salowe, Laura O’Keefe, Sayaka Merriam, Roy Lee, Naira Khachatryan, Prithvi Sankar, Eydie Miller-Ellis, Amanda Lehman, Victoria Addis, Windell Murphy, Jeffrey Henderer, Maureen Maguire and Joan O’Brien

    Citation: BMC Medical Research Methodology 2017 17:101

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  10. Content type: Research article

    Inter-rater reliability (IRR) is mainly assessed based on only two reviewers of unknown expertise. The aim of this paper is to examine differences in the IRR of the Assessment of Multiple Systematic Reviews (AMST...

    Authors: Dawid Pieper, Anja Jacobs, Beate Weikert, Alba Fishta and Uta Wegewitz

    Citation: BMC Medical Research Methodology 2017 17:98

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  11. Content type: Research article

    Complex interventions such as self-management courses are difficult to evaluate due to the many interacting components. The way complex interventions are delivered can influence the effect they have for patien...

    Authors: G. Wojewodka, S. Hurley, S. J. C. Taylor, A. J. Noble, L. Ridsdale and L. H. Goldstein

    Citation: BMC Medical Research Methodology 2017 17:100

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  12. Content type: Research article

    Data cleaning is an important quality assurance in data linkage research studies. This paper presents the data cleaning and preparation process for a large-scale cross-jurisdictional Australian study (the Smok...

    Authors: Duong Thuy Tran, Alys Havard and Louisa R. Jorm

    Citation: BMC Medical Research Methodology 2017 17:97

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  13. Content type: Research article

    Probabilistic record linkage is a process used to bring together person-based records from within the same dataset (de-duplication) or from disparate datasets using pairwise comparisons and matching probabilit...

    Authors: Adrian P. Brown, Sean M. Randall, Anna M. Ferrante, James B. Semmens and James H. Boyd

    Citation: BMC Medical Research Methodology 2017 17:95

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  14. Content type: Research article

    Selection bias and non-participation bias are major methodological concerns which impact external validity. Cluster-randomized controlled trials are especially prone to selection bias as it is impractical to b...

    Authors: Rochelle Yang, Barry L. Carter, Tyler H. Gums, Brian M. Gryzlak, Yinghui Xu and Barcey T. Levy

    Citation: BMC Medical Research Methodology 2017 17:94

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  15. Content type: Research article

    As publishing is essential but competitive for researchers, difficulties in writing and submitting medical articles to biomedical journals are disabling. The DIAzePAM (Difficultés des Auteurs à la Publication d’A...

    Authors: Martin Duracinsky, Christophe Lalanne, Laurence Rous, Aichata Fofana Dara, Lesya Baudoin, Claire Pellet, Alexandre Descamps, Fabienne Péretz and Olivier Chassany

    Citation: BMC Medical Research Methodology 2017 17:96

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  16. Content type: Research article

    To illustrate the 10-year risks of urinary adverse events (UAEs) among men diagnosed with prostate cancer and treated with different types of therapy, accounting for the competing risk of death.

    Authors: Charlotte A. Bolch, Haitao Chu, Stephanie Jarosek, Stephen R. Cole, Sean Elliott and Beth Virnig

    Citation: BMC Medical Research Methodology 2017 17:93

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  17. Content type: Research Article

    Composite endpoints comprising hospital admissions and death are the primary outcome in many cardiovascular clinical trials. For statistical analysis, a Cox proportional hazards model for the time to first eve...

    Authors: Antje Jahn-Eimermacher, Katharina Ingel, Stella Preussler, Antoni Bayes-Genis and Harald Binder

    Citation: BMC Medical Research Methodology 2017 17:92

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  18. Content type: Research Article

    There are a growing number of observational studies that do not only focus on single biomarkers for predicting an outcome event, but address questions in a multivariable setting. For example, when quantifying ...

    Authors: Andreas Schulz, Daniela Zöller, Stefan Nickels, Manfred E. Beutel, Maria Blettner, Philipp S. Wild and Harald Binder

    Citation: BMC Medical Research Methodology 2017 17:90

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  19. Content type: Research article

    Administrative data is a useful tool for research and quality improvement; however, validity of research findings based on these data depends on their reliability. Diagnoses assigned by physicians are subseque...

    Authors: Kristin Burles, Grant Innes, Kevin Senior, Eddy Lang and Andrew McRae

    Citation: BMC Medical Research Methodology 2017 17:89

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  20. Content type: Research article

    The nested case-control study (NCC) design within a prospective cohort study is used when outcome data are available for all subjects, but the exposure of interest has not been collected, and is difficult or p...

    Authors: Long H. Ngo, Sharon K. Inouye, Richard N. Jones, Thomas G. Travison, Towia A. Libermann, Simon T. Dillon, George A. Kuchel, Sarinnapha M. Vasunilashorn, David C. Alsop and Edward R. Marcantonio

    Citation: BMC Medical Research Methodology 2017 17:88

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