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  1. Estimating harm rates for specific patient populations and detecting significant changes in them over time are essential if patient safety in general practice is to be improved. Clinical record review (CRR) is...

    Authors: Carl de Wet, Paul Johnson, Catherine O’Donnell and Paul Bowie
    Citation: BMC Medical Research Methodology 2013 13:39
  2. Following publication of the first worked example of the “best fit” method of evidence synthesis for the systematic review of qualitative evidence in this journal, the originators of the method identified a ne...

    Authors: Christopher Carroll, Andrew Booth, Joanna Leaviss and Jo Rick
    Citation: BMC Medical Research Methodology 2013 13:37
  3. Life expectancy is of increasing prime interest for a variety of reasons. In many countries, life expectancy is growing linearly, without any indication of reaching a limit. The state of North Rhine–Westphalia...

    Authors: Dankmar Böhning, Sarah Karasek, Claudia Terschüren, Rolf Annuß and Rainer Fehr
    Citation: BMC Medical Research Methodology 2013 13:36
  4. In network meta-analyses, several treatments can be compared by connecting evidence from clinical trials that have investigated two or more treatments. The resulting trial network allows estimating the relativ...

    Authors: Ulrike Krahn, Harald Binder and Jochem König
    Citation: BMC Medical Research Methodology 2013 13:35
  5. Estimating the incidence of medical conditions using claims data often requires constructing a prevalence period that predates an event of interest, for instance the diagnosis of cancer, to exclude those with ...

    Authors: Robert I Griffiths, Cynthia D O’Malley, Robert J Herbert and Mark D Danese
    Citation: BMC Medical Research Methodology 2013 13:32
  6. Participation bias is a well-known phenomenon in epidemiologic research, where individuals consenting to research studies differ from individuals who are not able or willing to participate. These dissimilariti...

    Authors: Janet Raboud, DeSheng Su, Ann N Burchell, Sandra Gardner, Sharon Walmsley, Ahmed M Bayoumi, Sandra Blitz, Curtis Cooper, Irving Salit, Jeff Cohen, Sean B Rourke and Mona R Loutfy
    Citation: BMC Medical Research Methodology 2013 13:31
  7. In Germany, hospitals can deliver data from patients with pelvic fractures selectively or twofold to two different trauma registries, i.e. the German Pelvic Injury Register (PIR) and the TraumaRegister DGU® (T...

    Authors: Markus Burkhardt, Ulrike Nienaber, Joerg H Holstein, Ulf Culemann, Bertil Bouillon, Emin Aghayev, Thomas Paffrath, Marc Maegele, Tim Pohlemann and Rolf Lefering
    Citation: BMC Medical Research Methodology 2013 13:30
  8. Immunological correlates of protection are biological markers such as disease-specific antibodies which correlate with protection against disease and which are measurable with immunological assays. It is commo...

    Authors: Xuan Chen, Fabrice Bailleux, Kamal Desai, Li Qin and Andrew J Dunning
    Citation: BMC Medical Research Methodology 2013 13:29

    The Erratum to this article has been published in BMC Medical Research Methodology 2017 17:19

  9. The Center for Epidemiologic Studies - Depression scale (CES-D) is a validated tool commonly used to screen depressive symptoms. As with any self-administered questionnaire, missing data are frequently observe...

    Authors: Noémie Resseguier, Hélène Verdoux, Roch Giorgi, Françoise Clavel-Chapelon and Xavier Paoletti
    Citation: BMC Medical Research Methodology 2013 13:28
  10. Within longitudinal epidemiological research, ‘count’ outcome variables with an excess of zeros frequently occur. Although these outcomes are frequently analysed with a linear mixed model, or a Poisson mixed m...

    Authors: Alette S Spriensma, Tibor RS Hajos, Michiel R de Boer, Martijn W Heymans and Jos WR Twisk
    Citation: BMC Medical Research Methodology 2013 13:27
  11. The occurrence of communicable diseases (CD) depends on exposure to contagious persons. The effects of exposure to CD are delayed in time and contagious persons remain contagious for several days during which ...

    Authors: Cécile Payet, Nicolas Voirin, Philippe Vanhems and René Ecochard
    Citation: BMC Medical Research Methodology 2013 13:26
  12. When calculating the number of deaths attributable to alcohol consumption (i.e., the number of deaths that would not have occurred if everyone was a lifetime abstainer), alcohol consumption is most often model...

    Authors: Gerrit Gmel, Kevin D Shield, Tara AK Kehoe-Chan and Jürgen Rehm
    Citation: BMC Medical Research Methodology 2013 13:24
  13. Little evidence is available for the validity of dietary fish and polyunsaturated fatty acid intake derived from interviewer-administered questionnaires and plasma docosahexaenoic acid (DHA) and eicosapentaeno...

    Authors: Kuo-Liong Chien, Meei-Shyuan Lee, Yi-Tsen Tsai, Pey-Rong Chen, Hung-Ju Lin, Hsiu-Ching Hsu, Yuan-The Lee and Ming-Fong Chen
    Citation: BMC Medical Research Methodology 2013 13:23
  14. Diabetes–related lower limb amputations are associated with considerable morbidity and mortality and are usually preceded by foot ulceration. The available systematic reviews of aggregate data are compromised ...

    Authors: Fay Crawford, Chantelle Anandan, Francesca M Chappell, Gordon D Murray, Jacqueline F Price, Aziz Sheikh, Colin R Simpson, Martin Maxwell, Gerard P Stansby, Matthew J Young, Caroline A Abbott, Andrew JM Boulton, Edward J Boyko, Thomas Kastenbauer, Graham P Leese, Matteo Monami…
    Citation: BMC Medical Research Methodology 2013 13:22
  15. Interaction in clinical trials presents challenges for design and appropriate sample size estimation. Here we considered interaction between treatment assignment and a dichotomous prognostic factor with a cont...

    Authors: William M Reichmann, Michael P LaValley, David R Gagnon and Elena Losina
    Citation: BMC Medical Research Methodology 2013 13:21
  16. Multiple sclerosis (MS), a common neurodegenerative disease, has well-described associations with quality of life (QoL) impairment. QoL changes found in longitudinal studies are difficult to interpret due to t...

    Authors: Mohamed Boucekine, Anderson Loundou, Karine Baumstarck, Patricia Minaya-Flores, Jean Pelletier, Badih Ghattas and Pascal Auquier
    Citation: BMC Medical Research Methodology 2013 13:20
  17. When study data are clustered, standard regression analysis is considered inappropriate and analytical techniques for clustered data need to be used. For prediction research in which the interest of predictor ...

    Authors: Walter Bouwmeester, Jos WR Twisk, Teus H Kappen, Wilton A van Klei, Karel GM Moons and Yvonne Vergouwe
    Citation: BMC Medical Research Methodology 2013 13:19
  18. Case-control studies are generally designed to investigate the effect of exposures on the risk of a disease. Detailed information on past exposures is collected at the time of study. However, only the cumulate...

    Authors: Héloïse Gauvin, Aude Lacourt and Karen Leffondré
    Citation: BMC Medical Research Methodology 2013 13:18
  19. Statutory State-based cancer registries are considered the ‘gold standard’ for researchers identifying cancer cases in Australia, but research using self-report or administrative health datasets (e.g. hospital...

    Authors: Anna Kemp, David B Preen, Christobel Saunders, C D’Arcy J Holman, Max Bulsara, Kris Rogers and Elizabeth E Roughead
    Citation: BMC Medical Research Methodology 2013 13:17
  20. Research suggests that there are a number of factors which can be associated with delay in a patient seeking professional help following chest pain, including demographic and social factors. These factors may ...

    Authors: Susan K Baxter and Peter Allmark
    Citation: BMC Medical Research Methodology 2013 13:15
  21. Longitudinal qualitative methods are becoming increasingly used in the health service research, but the method and challenges particular to health care settings are not well described in the literature.We refl...

    Authors: Lynn Calman, Lisa Brunton and Alex Molassiotis
    Citation: BMC Medical Research Methodology 2013 13:14
  22. Proper evaluation of new diagnostic tests is required to reduce overutilization and to limit potential negative health effects and costs related to testing. A decision analytic modelling approach may be worthw...

    Authors: Hendrik Koffijberg, Bas van Zaane and Karel GM Moons
    Citation: BMC Medical Research Methodology 2013 13:12
  23. Efficient HIV prevention requires accurate identification of individuals with risky sexual behaviour. However, self-reported data from sexual behaviour surveys are prone to social desirability bias (SDB). Audi...

    Authors: Roxanne Beauclair, Fei Meng, Nele Deprez, Marleen Temmerman, Alex Welte, Niel Hens and Wim Delva
    Citation: BMC Medical Research Methodology 2013 13:11
  24. Treatment burden can be defined as the self-care practices that patients with chronic illness must perform to respond to the requirements of their healthcare providers, as well as the impact that these practic...

    Authors: Katie Gallacher, Bhautesh Jani, Deborah Morrison, Sara Macdonald, David Blane, Patricia Erwin, Carl R May, Victor M Montori, David T Eton, Fiona Smith, David G Batty and Frances S Mair
    Citation: BMC Medical Research Methodology 2013 13:10

    The Erratum to this article has been published in BMC Medical Research Methodology 2014 13:160

  25. The objective of this simulation study is to compare the accuracy and efficiency of population-averaged (i.e. generalized estimating equations (GEE)) and cluster-specific (i.e. random-effects logistic regressi...

    Authors: Jinhui Ma, Parminder Raina, Joseph Beyene and Lehana Thabane
    Citation: BMC Medical Research Methodology 2013 13:9
  26. Delirium (acute confusion), is a common, morbid, and costly complication of acute illness in older adults. Yet, researchers and clinicians lack short, efficient, and sensitive case identification tools for del...

    Authors: Frances M Yang, Richard N Jones, Sharon K Inouye, Douglas Tommet, Paul K Crane, James L Rudolph, Long H Ngo and Edward R Marcantonio
    Citation: BMC Medical Research Methodology 2013 13:8
  27. Systematic reviews provide clinical practice recommendations that are based on evaluation of primary evidence. When systematic reviews with the same aims have different conclusions, it is difficult to ascertai...

    Authors: Cherie Wells, Gregory S Kolt, Paul Marshall, Bridget Hill and Andrea Bialocerkowski
    Citation: BMC Medical Research Methodology 2013 13:7
  28. Plasma glucose levels are important measures in medical care and research, and are often obtained from oral glucose tolerance tests (OGTT) with repeated measurements over 2–3 hours. It is common practice to us...

    Authors: Kathrine Frey Frøslie, Jo Røislien, Elisabeth Qvigstad, Kristin Godang, Jens Bollerslev, Nanna Voldner, Tore Henriksen and Marit B Veierød
    Citation: BMC Medical Research Methodology 2013 13:6
  29. To quantify the variability among centers and to identify centers whose performance are potentially outside of normal variability in the primary outcome and to propose a guideline that they are outliers.

    Authors: Emine O Bayman, Kathryn M Chaloner, Bradley J Hindman and Michael M Todd
    Citation: BMC Medical Research Methodology 2013 13:5
  30. Existing incidence estimates of heroin use are usually based on one information source. This study aims to incorporate more sources to estimate heroin use incidence trends in Spain between 1971 and 2005.

    Authors: Albert Sánchez-Niubò, Odd O Aalen, Antònia Domingo-Salvany, Ellen J Amundsen, Josep Fortiana and Kjetil Røysland
    Citation: BMC Medical Research Methodology 2013 13:4
  31. Although in health services survey research we strive for a high response rate, this must be balanced against the need to recruit participants ethically and considerately, particularly in surveys with a sensit...

    Authors: Katherine J Hunt, Natalie Shlomo and Julia Addington-Hall
    Citation: BMC Medical Research Methodology 2013 13:3
  32. Multiple treatment comparison (MTC) meta-analyses are commonly modeled in a Bayesian framework, and weakly informative priors are typically preferred to mirror familiar data driven frequentist approaches. Rand...

    Authors: Kristian Thorlund, Lehana Thabane and Edward J Mills
    Citation: BMC Medical Research Methodology 2013 13:2
  33. To assess how authors would describe their contribution to the submitted manuscript without reference to or requirement to satisfy authorship criteria of the International Committee of Medical Journal Editors ...

    Authors: Mario Malički, Ana Jerončić, Matko Marušić and Ana Marušić
    Citation: BMC Medical Research Methodology 2012 12:189
  34. There is growing interest in assisted living technologies to support independence at home. Such technologies should ideally be designed ‘in the wild’ i.e. taking account of how real people live in real homes a...

    Authors: Joseph Wherton, Paul Sugarhood, Rob Procter, Mark Rouncefield, Guy Dewsbury, Sue Hinder and Trisha Greenhalgh
    Citation: BMC Medical Research Methodology 2012 12:188
  35. Systematic reviews have been challenged to consider effects on disadvantaged groups. A priori specification of subgroup analyses is recommended to increase the credibility of these analyses. This study aimed t...

    Authors: Vivian Welch, Kevin Brand, Elizabeth Kristjansson, Janet Smylie, George Wells and Peter Tugwell
    Citation: BMC Medical Research Methodology 2012 12:187
  36. In research with long-term follow-up and repeated measurements, quick and complete response to questionnaires helps ensure a study’s validity, precision and efficiency. Evidence on the effect of non-monetary i...

    Authors: Lonneke B van der Mark, Karina E van Wonderen, Jacob Mohrs, Patrick JE Bindels, Milo A Puhan and Gerben ter Riet
    Citation: BMC Medical Research Methodology 2012 12:186
  37. Implicit in the growing interest in patient-centered outcomes research is a growing need for better evidence regarding how responses to a given intervention or treatment may vary across patients, referred to a...

    Authors: Richard J Willke, Zhiyuan Zheng, Prasun Subedi, Rikard Althin and C Daniel Mullins
    Citation: BMC Medical Research Methodology 2012 12:185
  38. Multiple imputation is becoming increasingly popular. Theoretical considerations as well as simulation studies have shown that the inclusion of auxiliary variables is generally of benefit.

    Authors: Jochen Hardt, Max Herke and Rainer Leonhart
    Citation: BMC Medical Research Methodology 2012 12:184
  39. This study aims at analyzing Health related quality of life (HRQoL) data on the French general population between 1995 and 2003 using an Item Response Theory (IRT) model.

    Authors: Jean-Benoit Hardouin, Etienne Audureau, Alain Leplège and Joël Coste
    Citation: BMC Medical Research Methodology 2012 12:182
  40. The syntheses of multiple qualitative studies can pull together data across different contexts, generate new theoretical or conceptual models, identify research gaps, and provide evidence for the development, ...

    Authors: Allison Tong, Kate Flemming, Elizabeth McInnes, Sandy Oliver and Jonathan Craig
    Citation: BMC Medical Research Methodology 2012 12:181
  41. Adjusting for laboratory test results may result in better confounding control when added to administrative claims data in the study of treatment effects. However, missing values can arise through several mech...

    Authors: Sebastian Schneeweiss, Jeremy A Rassen, Robert J Glynn, Jessica Myers, Gregory W Daniel, Joseph Singer, Daniel H Solomon, SeoYoung Kim, Kenneth J Rothman, Jun Liu and Jerry Avorn
    Citation: BMC Medical Research Methodology 2012 12:180
  42. Participant attrition in longitudinal studies can introduce systematic bias, favoring participants who return for follow-up, and increase the likelihood that those with complications will be underestimated. Ou...

    Authors: Janey C Peterson, Paul A Pirraglia, Martin T Wells and Mary E Charlson
    Citation: BMC Medical Research Methodology 2012 12:178

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