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  1. If intervention A bests B in one randomized trial, and B bests C in another randomized trial, can one conclude that A is better than C? The problem was motivated by the planning of a randomized trial, where A ...

    Authors: Stuart G Baker and Barnett S Kramer
    Citation: BMC Medical Research Methodology 2002 2:13
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Medical Research Methodology 2003 3:23

  3. The evaluation of randomized trials for cancer screening involves special statistical considerations not found in therapeutic trials. Although some of these issues have been discussed previously, we present im...

    Authors: Stuart G Baker, Barnett S Kramer and Philip C Prorok
    Citation: BMC Medical Research Methodology 2002 2:11
    Content type: Research article Published on:

  4. Meta-analysis is often considered to be a simple way to summarize the existing literature. In this paper we describe how a meta-analysis resembles a conventional study, requiring a written protocol with design...

    Authors: Nancy G Berman and Robert A Parker
    Citation: BMC Medical Research Methodology 2002 2:10
    Content type: Research article Published on:

  5. Although guidelines for critical appraisal of diagnostic research and meta-analyses have already been published, these may be difficult to understand for clinical researchers or do not provide enough detailed ...

    Authors: Walter L Devillé, Frank Buntinx, Lex M Bouter, Victor M Montori, Henrica CW de Vet, Danielle AWM van der Windt and P Dick Bezemer
    Citation: BMC Medical Research Methodology 2002 2:9
    Content type: Research article Published on:

  6. Readers may question the interpretation of findings in clinical trials when multiple outcome measures are used without adjustment of the p-value. This question arises because of the increased risk of Type I er...

    Authors: Ronald J Feise
    Citation: BMC Medical Research Methodology 2002 2:8
    Content type: Debate Published on:

  7. The aim of this study was to examine the determinants of publication and whether publication bias occurred in gastroenterological research.

    Authors: Antje Timmer, Robert J Hilsden, John Cole, David Hailey and Lloyd R Sutherland
    Citation: BMC Medical Research Methodology 2002 2:7
    Content type: Research article Published on:

  8. Language bias is a form of publication bias and constitutes a serious threat to meta-analyses. The Cochrane Controlled Trials Register is one attempt to remedy this and now contains more than 300,000 citations...

    Authors: Toshi A Furukawa, Toshiya Inada, Clive E Adams, Hugh McGuire, Ataru Inagaki and Shoko Nozaki
    Citation: BMC Medical Research Methodology 2002 2:6
    Content type: Research article Published on:

  9. The study of cost-effectiveness comparisons between competing medical interventions has led to a variety of proposals for quantifying cost-effectiveness. The differences between the various approaches can be s...

    Authors: Anthony O'Hagan and John W Stevens
    Citation: BMC Medical Research Methodology 2002 2:5
    Content type: Debate Published on:

  10. Recently many long-term prospective studies have involved serial collection and storage of blood or tissue specimens. This has spurred nested case-control studies that involve testing some specimens for variou...

    Authors: Stuart G Baker, Barnett S Kramer and Sudhir Srivastava
    Citation: BMC Medical Research Methodology 2002 2:4
    Content type: Research article Published on:

  12. To consider the problem of the calculation of number needed to treat (NNT) derived from risk difference, odds ratio, and raw pooled events shown to give different results using data from a review of nursing in...

    Authors: R Andrew Moore, David J Gavaghan, Jayne E Edwards, Phillip Wiffen and Henry J McQuay
    Citation: BMC Medical Research Methodology 2002 2:2
    Content type: Debate Published on:

  15. The Digestive Diseases Week (DDW) is the major meeting for presentation of research in gastroenterology. The acceptance of an abstract for presentation at this meeting is the most important determinant of subs...

    Authors: Antje Timmer, Robert J Hilsden and Lloyd R Sutherland
    Citation: BMC Medical Research Methodology 2001 1:13
    Content type: Research article Published on:

  16. Response rates to surveys are declining and this threatens the validity and generalisability of their findings. We wanted to determine whether paper quality influences the response rate to postal surveys

    Authors: T Justin Clark, Khalid S Khan and Janesh K Gupta
    Citation: BMC Medical Research Methodology 2001 1:12
    Content type: Research article Published on:

  17. Published formulas for case-control designs provide sample sizes required to determine that a given disease-exposure odds ratio is significantly different from one, adjusting for a potential confounder and pos...

    Authors: Michael D Edwardes
    Citation: BMC Medical Research Methodology 2001 1:11
    Content type: Research article Published on:

  19. Although a randomized trial represents the most rigorous method of evaluating a medical intervention, some interventions would be extremely difficult to evaluate using this study design. One alternative, an ob...

    Authors: Stuart G Baker, Karen S Lindeman and Barnett S Kramer
    Citation: BMC Medical Research Methodology 2001 1:9
    Content type: Research article Published on:

  21. We would expect information on adverse drug reactions in randomised clinical trials to be easily retrievable from specific searches of electronic databases. However, complete retrieval of such information may ...

    Authors: Sheena Derry, Yoon Kong Loke and Jeffrey K Aronson
    Citation: BMC Medical Research Methodology 2001 1:7
    Content type: Research article Published on:

  22. Many randomized trials involve measuring a continuous outcome - such as pain, body weight or blood pressure - at baseline and after treatment. In this paper, I compare four possibilities for how such trials ca...

    Authors: Andrew J Vickers
    Citation: BMC Medical Research Methodology 2001 1:6
    Content type: Research article Published on:

  23. In order to assess the usefulness of radiolabeled white cell scanning in the diagnosis of intestinal inflammation, subjects were asked to rank several dimensions of preference for white cell scanning in relati...

    Authors: Richard L Nelson, Alan Schwartz and Dan Pavel
    Citation: BMC Medical Research Methodology 2001 1:5
    Content type: Research article Published on:

  24. We examined whether quarterly patient enrollment in a large multicenter clinical trials group could be modeled in terms of predictors including time parameters (such as long-term trends and seasonality), the e...

    Authors: Anna-Bettina Haidich and John PA Ioannidis
    Citation: BMC Medical Research Methodology 2001 1:4
    Content type: Research article Published on:

  25. Guidelines published in major medical journals are very influential in determining clinical practice. It would be essential to evaluate whether conflicts of interests are disclosed in these publications. We ev...

    Authors: George N Papanikolaou, Maria S Baltogianni, Despina G Contopoulos-Ioannidis, Anna-Bettina Haidich, Ioannis A Giannakakis and John PA Ioannidis
    Citation: BMC Medical Research Methodology 2001 1:3
    Content type: Research article Published on:

  26. To comprehend the results of a randomized controlled trial (RCT), readers must understand its design, conduct, analysis and interpretation. That goal can only be achieved through complete transparency from aut...

    Authors: David Moher, Kenneth F Schulz and Douglas G Altman
    Citation: BMC Medical Research Methodology 2001 1:2
    Content type: Research article Published on:

  27. Meta-analysis usually restricts the information pooled, for instance using only randomised, double-blind, placebo-controlled trials. This neglects other types of high quality information. This review explores ...

    Authors: Lesley A Smith, R Andrew Moore, Henry J McQuay and David Gavaghan
    Citation: BMC Medical Research Methodology 2001 1:1
    Content type: Research article Published on:
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BMC Medical Research Methodology

ISSN: 1471-2288

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