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  1. The determinants of participation in long-term follow-up studies of disasters have rarely been delineated. Even less is known from studies of events that occurred in eastern Europe. We examined the factors ass...

    Authors: Lin T Guey, Evelyn J Bromet, Semyon F Gluzman, Victoria Zakhozha and Vlodomyr Paniotto

    Citation: BMC Medical Research Methodology 2008 8:27

    Content type: Research article

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  2. Changes of health and quality-of-life in chronic conditions are mostly small and require specific and sensitive instruments. The aim of this study was to determine and compare responsiveness, i.e. the sensitiv...

    Authors: Felix Angst, Martin L Verra, Susanne Lehmann and André Aeschlimann

    Citation: BMC Medical Research Methodology 2008 8:26

    Content type: Research article

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  3. Hospital-based discharge registries are used increasingly for longitudinal epidemiological studies of HIV. We examined completeness of registration of HIV infections and of chronic hepatitis B (HBV) and hepati...

    Authors: Niels Obel, Hanne Reinholdt, Lars H Omland, Frederik Engsig, Henrik T Sørensen and Ann-Brit E Hansen

    Citation: BMC Medical Research Methodology 2008 8:25

    Content type: Research article

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  4. The within-subject coefficient of variation and intra-class correlation coefficient are commonly used to assess the reliability or reproducibility of interval-scale measurements. Comparison of reproducibility ...

    Authors: Mohamed M Shoukri, Dilek Colak, Namik Kaya and Allan Donner

    Citation: BMC Medical Research Methodology 2008 8:24

    Content type: Research article

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  5. The analysis of non-fatal recurring events is frequently found in studies on chronic-degenerative diseases. The aim of this paper is to estimate the probability of readmission of patients with Chronic Obstruct...

    Authors: Nicola Bartolomeo, Paolo Trerotoli, Annamaria Moretti and Gabriella Serio

    Citation: BMC Medical Research Methodology 2008 8:23

    Content type: Research article

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  7. Qualitative synthesis has become more commonplace in recent years. Meta-ethnography is one of several methods for synthesising qualitative research and is being used increasingly within health care research. H...

    Authors: Salla Atkins, Simon Lewin, Helen Smith, Mark Engel, Atle Fretheim and Jimmy Volmink

    Citation: BMC Medical Research Methodology 2008 8:21

    Content type: Debate

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  8. Graphical displays of results allow researchers to summarise and communicate the key findings of their study. Diagnostic information should be presented in an easily interpretable way, which conveys both test ...

    Authors: Penny F Whiting, Jonathan AC Sterne, Marie E Westwood, Lucas M Bachmann, Roger Harbord, Matthias Egger and Jonathan J Deeks

    Citation: BMC Medical Research Methodology 2008 8:20

    Content type: Correspondence

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  9. Potentially, unit-specific in-vitro calibration of accelerometers could increase field data quality and study power. However, reduced inter-unit variability would only be important if random instrument variabi...

    Authors: Niels C Moeller, Lars Korsholm, Peter L Kristensen, Lars B Andersen, Niels Wedderkopp and Karsten Froberg

    Citation: BMC Medical Research Methodology 2008 8:19

    Content type: Research article

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  10. Published false positive research findings are a major problem in the process of scientific discovery. There is a high rate of lack of replication of results in clinical research in general, multiple sclerosis...

    Authors: Martin Daumer, Ulrike Held, Katja Ickstadt, Moritz Heinz, Siegfried Schach and George Ebers

    Citation: BMC Medical Research Methodology 2008 8:18

    Content type: Research article

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  11. Non-participants can have a considerable influence on the external validity of a study. Therefore, we assessed the socio-demographic, health-related, and lifestyle behavioral differences between participants a...

    Authors: Jeroen Lakerveld, Wilhelmina IJzelenberg, Maurits W van Tulder, Irene M Hellemans, Jan A Rauwerda, Albert C van Rossum and Jaap C Seidell

    Citation: BMC Medical Research Methodology 2008 8:17

    Content type: Research article

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  13. Public health benefits from research often rely on the use of data from personal medical records. When neither patient consent nor anonymisation is possible, the case for accessing such records for research pu...

    Authors: Una Macleod and Graham CM Watt

    Citation: BMC Medical Research Methodology 2008 8:15

    Content type: Research article

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  15. As in any measurement process, a certain amount of error may be expected in routine population surveillance operations such as those in demographic surveillance sites (DSSs). Vital events are likely to be miss...

    Authors: Edward Fottrell, Peter Byass and Yemane Berhane

    Citation: BMC Medical Research Methodology 2008 8:13

    Content type: Research article

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  16. Interim analysis of accumulating trial data is important to protect participant safety during randomized controlled trials (RCTs). Data Monitoring Committees (DMCs) often undertake such analyses, but their wid...

    Authors: Puvan Tharmanathan, Melanie Calvert, John Hampton and Nick Freemantle

    Citation: BMC Medical Research Methodology 2008 8:12

    Content type: Correspondence

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  17. When a therapy has been evaluated in the first clinical study, the outcome is often compared descriptively to outcomes in corresponding cohorts receiving other treatments. Such comparisons are often limited to...

    Authors: Harald J Hamre, Anja Glockmann, Wilfried Tröger, Gunver S Kienle and Helmut Kiene

    Citation: BMC Medical Research Methodology 2008 8:11

    Content type: Research article

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  18. Little is known about the impact of data collection method on self-reported cancer screening behaviours, particularly among hard-to-reach populations. The purpose of this study is to examine the effects of dat...

    Authors: Melissa A Clark, Michelle L Rogers, Gene F Armstrong, William Rakowski and Frederick J Kviz

    Citation: BMC Medical Research Methodology 2008 8:10

    Content type: Research article

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  19. It is usually preferable to model and estimate prevalence ratios instead of odds ratios in cross-sectional studies when diseases or injuries are not rare. Problems with existing methods of modeling prevalence ...

    Authors: Martin R Petersen and James A Deddens

    Citation: BMC Medical Research Methodology 2008 8:9

    Content type: Research article

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  20. One attraction of meta-analysis is the forest plot, a compact overview of the essential data included in a systematic review and the overall 'result'. However, meta-analysis is not always suitable for synthesi...

    Authors: David Ogilvie, Debra Fayter, Mark Petticrew, Amanda Sowden, Sian Thomas, Margaret Whitehead and Gill Worthy

    Citation: BMC Medical Research Methodology 2008 8:8

    Content type: Research article

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  21. A spectrum effect was defined as differences in the sensitivity or specificity of a diagnostic test according to the patient's characteristics or disease features. A spectrum effect can lead to a spectrum bias...

    Authors: Caroline Elie and Joël Coste

    Citation: BMC Medical Research Methodology 2008 8:7

    Content type: Research article

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  22. Malaria is a major public health problem in Malawi, however, quantifying its burden in a population is a challenge. Routine hospital data provide a proxy for measuring the incidence of severe malaria and for c...

    Authors: Lawrence N Kazembe, Tobias F Chirwa, Jupiter S Simbeye and Jimmy J Namangale

    Citation: BMC Medical Research Methodology 2008 8:6

    Content type: Research article

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  23. Electronic monitoring (EM) is used increasingly to measure medication non-adherence. Unbiased EM assessment requires fulfillment of assumptions. The purpose of this study was to determine assumptions needed fo...

    Authors: Kris Denhaerynck, Petra Schäfer-Keller, James Young, Jürg Steiger, Andreas Bock and Sabina De Geest

    Citation: BMC Medical Research Methodology 2008 8:5

    Content type: Research article

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  24. Negative pressure wound therapy (NPWT) is widely applied, although the evidence base is weak. Previous reviews on medical interventions have shown that conclusions based on published data alone may no longer h...

    Authors: Frank Peinemann, Natalie McGauran, Stefan Sauerland and Stefan Lange

    Citation: BMC Medical Research Methodology 2008 8:4

    Content type: Research article

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  26. Missing data may bias the results of clinical trials and other studies. This study describes the response rate, questionnaire responses and financial costs associated with offering participants from a multilin...

    Authors: Elizabeth Dormandy, Katrina Brown, Erin P Reid and Theresa M Marteau

    Citation: BMC Medical Research Methodology 2008 8:2

    Content type: Research article

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  27. We have previously described a method for dealing with missing data in a prospective cardiac registry initiative. The method involves merging registry data to corresponding ICD-9-CM administrative data to fill...

    Authors: Danielle A Southern, Colleen M Norris, Hude Quan, Fiona M Shrive, P Diane Galbraith, Karin Humphries, Min Gao, Merril L Knudtson and William A Ghali

    Citation: BMC Medical Research Methodology 2008 8:1

    Content type: Research article

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  28. Incidence and lifetime risk of diabetes are important public health measures. Traditionally, nonparametric estimates are obtained from survey data by means of a Nelson-Aalen estimator which requires data infor...

    Authors: Henrik Støvring and Mei-Cheng Wang

    Citation: BMC Medical Research Methodology 2007 7:53

    Content type: Research article

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  29. The criteria for stopping Delphi studies are often subjective. This study aimed to examine whether consensus and stability in the Delphi process can be ascertained by descriptive evaluation of trends in partic...

    Authors: Elizabeth A Holey, Jennifer L Feeley, John Dixon and Vicki J Whittaker

    Citation: BMC Medical Research Methodology 2007 7:52

    Content type: Research article

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  30. Low response and reporting errors are major concerns for survey epidemiologists. However, while nonresponse is commonly investigated, the effects of misclassification are often ignored, possibly because they a...

    Authors: A Rosemary Tate, Margaret Jones, Lisa Hull, Nicola T Fear, Roberto Rona, Simon Wessely and Matthew Hotopf

    Citation: BMC Medical Research Methodology 2007 7:51

    Content type: Research article

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  31. The most commonly used survey methods are self-administered questionnaires, telephone interviews, and a mixture of both. But until now evidence out of randomised controlled trials as to whether patient respons...

    Authors: Margitta Lungenhausen, Stefan Lange, Christoph Maier, Claudia Schaub, Hans J Trampisch and Heinz G Endres

    Citation: BMC Medical Research Methodology 2007 7:50

    Content type: Research article

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  34. Although there have been reported benefits of health education interventions across various health issues, the key to program effectiveness is participation and retention. Unfortunately, not everyone is willin...

    Authors: Enza Gucciardi, Jill I Cameron, Chen Di Liao, Alison Palmer and Donna E Stewart

    Citation: BMC Medical Research Methodology 2007 7:47

    Content type: Research article

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  35. The lack of robust systems for monitoring quality in healthcare has been highlighted. Statistical process control (SPC) methods, utilizing the increasingly available routinely collected electronic patient reco...

    Authors: Thabani Sibanda and Nokuthaba Sibanda

    Citation: BMC Medical Research Methodology 2007 7:46

    Content type: Research article

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  36. Birth weight and length have seasonal fluctuations. Previous analyses of birth weight by latitude effects identified seemingly contradictory results, showing both 6 and 12 monthly periodicities in weight. The ...

    Authors: John McGrath, Adrian Barnett, Darryl Eyles, Thomas Burne, Carsten B Pedersen and Preben Bo Mortensen

    Citation: BMC Medical Research Methodology 2007 7:45

    Content type: Research article

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  37. In an effort to identify previously unrecognized aspects of editorial decision-making, we explored the words and phrases that one group of editors used during their meetings.

    Authors: Kay Dickersin, Elizabeth Ssemanda, Catherine Mansell and Drummond Rennie

    Citation: BMC Medical Research Methodology 2007 7:44

    Content type: Research article

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  38. Disorders related to pregnancy and childbirth are a major health issue in South East Asia. They represent one of the biggest health risk differentials between the developed and developing world. Our broad rese...

    Authors: David J Henderson-Smart, Pisake Lumbiganon, Mario R Festin, Jacqueline J Ho, Hakimi Mohammad, Steve J McDonald, Sally Green and Caroline A Crowther

    Citation: BMC Medical Research Methodology 2007 7:43

    Content type: Study protocol

    Published on:

  39. Recruiting and retaining GPs for research can prove difficult, and may result in sub-optimal patient participation where GPs are required to recruit patients. Low participation rates may affect the validity of...

    Authors: Michelle K Williamson, Jane Pirkis, Jon J Pfaff, Orla Tyson, Moira Sim, Ngaire Kerse, Nicola T Lautenschlager, Nigel P Stocks and Osvaldo P Almeida

    Citation: BMC Medical Research Methodology 2007 7:42

    Content type: Research article

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  40. We aimed at assessing the degree of measurement error in essential fatty acid intakes from a food frequency questionnaire and the impact of correcting for such an error on precision and bias of odds ratios in ...

    Authors: May A Beydoun, Jay S Kaufman, Joseph Ibrahim, Jessie A Satia and Gerardo Heiss

    Citation: BMC Medical Research Methodology 2007 7:41

    Content type: Research article

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  42. This study compares the Bayesian and frequentist (non-Bayesian) approaches in the modelling of the association between the risk of preterm birth and maternal proximity to hazardous waste and pollution from the...

    Authors: Afisi S Ismaila, Angelo Canty and Lehana Thabane

    Citation: BMC Medical Research Methodology 2007 7:39

    Content type: Research article

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  43. The Bayesian approach is now widely recognised as a proper framework for analysing risk in health care. However, the traditional text-book Bayesian approach is in many cases difficult to implement, as it is ba...

    Authors: Terje Aven and Karianne Eidesen

    Citation: BMC Medical Research Methodology 2007 7:38

    Content type: Research article

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  44. The widespread international use of the 26-item WHO Quality of Life Instrument (WHOQOL-Bref) necessitates the assessment of its factor structure across cultures. For, alternative factor models may provide a be...

    Authors: Jude U Ohaeri, Abdel W Awadalla, Abdul-Hamid M El-Abassi and Anila Jacob

    Citation: BMC Medical Research Methodology 2007 7:37

    Content type: Research article

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  45. The purpose of this study was to validate the accuracy of an alternative cervical cancer test – visual inspection with acetic acid (VIA) – by addressing possible imperfections in the gold standard through late...

    Authors: Lynne Gaffikin, John A McGrath, Marc Arbyn and Paul D Blumenthal

    Citation: BMC Medical Research Methodology 2007 7:36

    Content type: Research article

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  48. Missing data is a challenging problem in many prognostic studies. Multiple imputation (MI) accounts for imputation uncertainty that allows for adequate statistical testing. We developed and tested a methodolog...

    Authors: Martijn W Heymans, Stef van Buuren, Dirk L Knol, Willem van Mechelen and Henrica CW de Vet

    Citation: BMC Medical Research Methodology 2007 7:33

    Content type: Research article

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  50. With the advent of high throughput genotyping technology and the information available via projects such as the human genome sequencing and the HapMap project, more and more data relevant to the study of genet...

    Authors: Angela J Frodsham and Julian PT Higgins

    Citation: BMC Medical Research Methodology 2007 7:31

    Content type: Research article

    Published on:

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