Table 2 Summary results for efficacy of paracetamol/codeine combinations and active comparators in randomised, double-blind, active- and placebo-controlled trials in acute pain
From: Using evidence from different sources: an example using paracetamol 1000 mg plus codeine 60 mg
Drug/dose | Number of | Patients with at | Percentage |
|---|---|---|---|
| Â | trials | least 50% pain | (95%CI) |
| Â | Â | relief/total | Â |
Paracetamol 300 mg + codeine 30 mg | 3 | 67/272 | 25 (20 to 30) |
Codeine 60 mg | 3 | 24/72 | 33 (22 to 44) |
Ibuprofen 400 mg | 2 | 28/72 | 39 (28 to 50) |
Paracetanol 600/650 mg | 10 | 135/311 | 43 (38 to 49) |
Paracetamol 1000 mg | 4 | 64/151 | 42 (35 to 50) |
Paracetamol 600 mg + codeine 60 mg | 13 | 191/398 | 48 (43 to 53) |
Diflusinal 500 mg | 3 | 54/90 | 60 (50 to 70) |
Ketorolac 10 mg | 3 | 75/117 | 64 (55 to 73) |
Diflusinal 1000 mg | 3 | 61/92 | 66 (57 to 76) |
Paracetamol 1000 mg + codeine 60 mg | 6 | 150/229 | 66 (59 to 72) |
Flurbiprofen 50 mg | 3 | 69/99 | 70 (61 to 79) |
Flurbiprofen 100 mg | 3 | 70/92 | 76 (67 to 85) |