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  1. Research article

    A comparison of multiple imputation methods for handling missing values in longitudinal data in the presence of a time-varying covariate with a non-linear association with time: a simulation study

    Missing data is a common problem in epidemiological studies, and is particularly prominent in longitudinal data, which involve multiple waves of data collection. Traditional multiple imputation (MI) methods (f...

    Anurika Priyanjali De Silva, Margarita Moreno-Betancur, Alysha Madhu De Livera, Katherine Jane Lee and Julie Anne Simpson

    BMC Medical Research Methodology 2017 17:114

    Published on: 25 July 2017

  2. Research Article

    Implementing the EffTox dose-finding design in the Matchpoint trial

    The Matchpoint trial aims to identify the optimal dose of ponatinib to give with conventional chemotherapy consisting of fludarabine, cytarabine and idarubicin to chronic myeloid leukaemia patients in blastic ...

    Kristian Brock, Lucinda Billingham, Mhairi Copland, Shamyla Siddique, Mirjana Sirovica and Christina Yap

    BMC Medical Research Methodology 2017 17:112

    Published on: 20 July 2017

  3. Research Article

    Binomial outcomes in dataset with some clusters of size two: can the dependence of twins be accounted for? A simulation study comparing the reliability of statistical methods based on a dataset of preterm infants

    The analysis of perinatal outcomes often involves datasets with some multiple births. These are datasets mostly formed of independent observations and a limited number of clusters of size two (twins) and maybe...

    Odile Sauzet and Janet L. Peacock

    BMC Medical Research Methodology 2017 17:110

    Published on: 20 July 2017

  4. Research Article

    Basic parametric analysis for a multi-state model in hospital epidemiology

    The extended illness-death model is a useful tool to study the risks and consequences of hospital-acquired infections (HAIs). The statistical quantities of interest are the transition-specific hazard rates and...

    Maja von Cube, Martin Schumacher and Martin Wolkewitz

    BMC Medical Research Methodology 2017 17:111

    Published on: 20 July 2017

  5. Research article

    Integrating data from randomized controlled trials and observational studies to predict the response to pregabalin in patients with painful diabetic peripheral neuropathy

    More patient-specific medical care is expected as more is learned about variations in patient responses to medical treatments. Analytical tools enable insights by linking treatment responses from different typ...

    Joe Alexander, Roger A. Edwards, Alberto Savoldelli, Luigi Manca, Roberto Grugni, Birol Emir, Ed Whalen, Stephen Watt, Marina Brodsky and Bruce Parsons

    BMC Medical Research Methodology 2017 17:113

    Published on: 20 July 2017

  6. Research Article

    A random effects meta-analysis model with Box-Cox transformation

    In a random effects meta-analysis model, true treatment effects for each study are routinely assumed to follow a normal distribution. However, normality is a restrictive assumption and the misspecification of ...

    Yusuke Yamaguchi, Kazushi Maruo, Christopher Partlett and Richard D. Riley

    BMC Medical Research Methodology 2017 17:109

    Published on: 19 July 2017

  7. Research article

    A literature review of applied adaptive design methodology within the field of oncology in randomised controlled trials and a proposed extension to the CONSORT guidelines

    The application of adaptive design methodology within a clinical trial setting is becoming increasingly popular. However the application of these methods within trials is not being reported as adaptive designs...

    Pankaj Mistry, Janet A Dunn and Andrea Marshall

    BMC Medical Research Methodology 2017 17:108

    Published on: 18 July 2017

  8. Debate

    Protocol adherence for continuously titrated interventions in randomized trials: an overview of the current methodology and case study

    The standard definition for protocol adherence is the proportion of all scheduled doses that are delivered. In clinical research, this definition has several limitations when evaluating protocol adherence in t...

    F. Lauzier, N. K. Adhikari, A. Seely, K. K. Y. Koo, E. P. Belley-Côté, K. E. A. Burns, D. J. Cook, F. D’Aragon, B. Rochwerg, M. E. Kho, S. J. W. Oczkowksi, E. H. Duan, M. O. Meade, A. G. Day and F. Lamontagne

    BMC Medical Research Methodology 2017 17:106

    Published on: 17 July 2017

  9. Research Article

    Nonlinear joint models for individual dynamic prediction of risk of death using Hamiltonian Monte Carlo: application to metastatic prostate cancer

    Joint models of longitudinal and time-to-event data are increasingly used to perform individual dynamic prediction of a risk of event. However the difficulty to perform inference in nonlinear models and to cal...

    Solène Desmée, France Mentré, Christine Veyrat-Follet, Bernard Sébastien and Jérémie Guedj

    BMC Medical Research Methodology 2017 17:105

    Published on: 17 July 2017

  10. Research article

    Cost and yield considerations when expanding recruitment for genetic studies: the primary open-angle African American glaucoma genetics study

    African Americans have been historically under-represented in genetic studies. More research is needed on effective recruitment strategies for this population, especially on approaches that supplement traditio...

    Rebecca Salowe, Laura O’Keefe, Sayaka Merriam, Roy Lee, Naira Khachatryan, Prithvi Sankar, Eydie Miller-Ellis, Amanda Lehman, Victoria Addis, Windell Murphy, Jeffrey Henderer, Maureen Maguire and Joan O’Brien

    BMC Medical Research Methodology 2017 17:101

    Published on: 14 July 2017

  11. Research article

    Accounting for treatment use when validating a prognostic model: a simulation study

    Prognostic models often show poor performance when applied to independent validation data sets. We illustrate how treatment use in a validation set can affect measures of model performance and present the uses...

    Romin Pajouheshnia, Linda M. Peelen, Karel G. M. Moons, Johannes B. Reitsma and Rolf H. H. Groenwold

    BMC Medical Research Methodology 2017 17:103

    Published on: 14 July 2017

  12. Research article

    Using structural equation modeling for network meta-analysis

    Network meta-analysis overcomes the limitations of traditional pair-wise meta-analysis by incorporating all available evidence into a general statistical framework for simultaneous comparisons of several treat...

    Yu-Kang Tu and Yun-Chun Wu

    BMC Medical Research Methodology 2017 17:104

    Published on: 14 July 2017

  13. Research article

    Data cleaning and management protocols for linked perinatal research data: a good practice example from the Smoking MUMS (Maternal Use of Medications and Safety) Study

    Data cleaning is an important quality assurance in data linkage research studies. This paper presents the data cleaning and preparation process for a large-scale cross-jurisdictional Australian study (the Smok...

    Duong Thuy Tran, Alys Havard and Louisa R. Jorm

    BMC Medical Research Methodology 2017 17:97

    Published on: 11 July 2017

  14. Research article

    Inter-rater reliability of AMSTAR is dependent on the pair of reviewers

    Inter-rater reliability (IRR) is mainly assessed based on only two reviewers of unknown expertise. The aim of this paper is to examine differences in the IRR of the Assessment of Multiple Systematic Reviews (AMST...

    Dawid Pieper, Anja Jacobs, Beate Weikert, Alba Fishta and Uta Wegewitz

    BMC Medical Research Methodology 2017 17:98

    Published on: 11 July 2017

  15. Research article

    Inverse probability of treatment-weighted competing risks analysis: an application on long-term risk of urinary adverse events after prostate cancer treatments

    To illustrate the 10-year risks of urinary adverse events (UAEs) among men diagnosed with prostate cancer and treated with different types of therapy, accounting for the competing risk of death.

    Charlotte A. Bolch, Haitao Chu, Stephanie Jarosek, Stephen R. Cole, Sean Elliott and Beth Virnig

    BMC Medical Research Methodology 2017 17:93

    Published on: 10 July 2017

  16. Research article

    Barriers to publishing in biomedical journals perceived by a sample of French researchers: results of the DIAzePAM study

    As publishing is essential but competitive for researchers, difficulties in writing and submitting medical articles to biomedical journals are disabling. The DIAzePAM (Difficultés des Auteurs à la Publication d’A...

    Martin Duracinsky, Christophe Lalanne, Laurence Rous, Aichata Fofana Dara, Lesya Baudoin, Claire Pellet, Alexandre Descamps, Fabienne Péretz and Olivier Chassany

    BMC Medical Research Methodology 2017 17:96

    Published on: 10 July 2017

  17. Research article

    Selection bias and subject refusal in a cluster-randomized controlled trial

    Selection bias and non-participation bias are major methodological concerns which impact external validity. Cluster-randomized controlled trials are especially prone to selection bias as it is impractical to b...

    Rochelle Yang, Barry L. Carter, Tyler H. Gums, Brian M. Gryzlak, Yinghui Xu and Barcey T. Levy

    BMC Medical Research Methodology 2017 17:94

    Published on: 10 July 2017

  18. Research article

    Estimating parameters for probabilistic linkage of privacy-preserved datasets

    Probabilistic record linkage is a process used to bring together person-based records from within the same dataset (de-duplication) or from disparate datasets using pairwise comparisons and matching probabilit...

    Adrian P. Brown, Sean M. Randall, Anna M. Ferrante, James B. Semmens and James H. Boyd

    BMC Medical Research Methodology 2017 17:95

    Published on: 10 July 2017

  19. Research Article

    A DAG-based comparison of interventional effect underestimation between composite endpoint and multi-state analysis in cardiovascular trials

    Composite endpoints comprising hospital admissions and death are the primary outcome in many cardiovascular clinical trials. For statistical analysis, a Cox proportional hazards model for the time to first eve...

    Antje Jahn-Eimermacher, Katharina Ingel, Stella Preussler, Antoni Bayes-Genis and Harald Binder

    BMC Medical Research Methodology 2017 17:92

    Published on: 4 July 2017

  20. Research Article

    Simulation of complex data structures for planning of studies with focus on biomarker comparison

    There are a growing number of observational studies that do not only focus on single biomarkers for predicting an outcome event, but address questions in a multivariable setting. For example, when quantifying ...

    Andreas Schulz, Daniela Zöller, Stefan Nickels, Manfred E. Beutel, Maria Blettner, Philipp S. Wild and Harald Binder

    BMC Medical Research Methodology 2017 17:90

    Published on: 13 June 2017

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