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  1. Research article

    Robust estimation of the expected survival probabilities from high-dimensional Cox models with biomarker-by-treatment interactions in randomized clinical trials

    Thanks to the advances in genomics and targeted treatments, more and more prediction models based on biomarkers are being developed to predict potential benefit from treatments in a randomized clinical trial. ...

    Nils Ternès, Federico Rotolo and Stefan Michiels

    BMC Medical Research Methodology 2017 17:83

    Published on: 22 May 2017

  2. Research article

    Changes in affect after completing a mailed survey about trauma: two pre- and post-test studies in former disability applicants for posttraumatic stress disorder

    One potential concern with using mailed surveys containing trauma-related content is the possibility of re-traumatizing survivors without a trained mental health professional present. Prior research provides i...

    Maureen Murdoch, Shannon Marie Kehle-Forbes and Melissa Ruth Partin

    BMC Medical Research Methodology 2017 17:81

    Published on: 10 May 2017

  3. Research Article

    On comparison of net survival curves

    Relative survival analysis is a subfield of survival analysis where competing risks data are observed, but the causes of death are unknown. A first step in the analysis of such data is usually the estimation o...

    Klemen Pavlič and Maja Pohar Perme

    BMC Medical Research Methodology 2017 17:79

    Published on: 2 May 2017

  4. Research article

    Double-adjustment in propensity score matching analysis: choosing a threshold for considering residual imbalance

    Double-adjustment can be used to remove confounding if imbalance exists after propensity score (PS) matching. However, it is not always possible to include all covariates in adjustment. We aimed to find the op...

    Tri-Long Nguyen, Gary S. Collins, Jessica Spence, Jean-Pierre Daurès, P. J. Devereaux, Paul Landais and Yannick Le Manach

    BMC Medical Research Methodology 2017 17:78

    Published on: 28 April 2017

  5. Research article

    Sample size and power determination when limited preliminary information is available

    We describe a novel strategy for power and sample size determination developed for studies utilizing investigational technologies with limited available preliminary data, specifically of imaging biomarkers. We...

    Christine E. McLaren, Wen-Pin Chen, Thomas D. O’Sullivan, Daniel L. Gillen, Min-Ying Su, Jeon H. Chen and Bruce J. Tromberg

    BMC Medical Research Methodology 2017 17:75

    Published on: 26 April 2017

  6. Research article

    The effectiveness of a monetary incentive offer on survey response rates and response completeness in a longitudinal study

    Achieving adequate response rates is an ongoing challenge for longitudinal studies. The World Trade Center Health Registry is a longitudinal health study that periodically surveys a cohort of ~71,000 people ex...

    Shengchao Yu, Howard E. Alper, Angela-Maithy Nguyen, Robert M. Brackbill, Lennon Turner, Deborah J. Walker, Carey B. Maslow and Kimberly C. Zweig

    BMC Medical Research Methodology 2017 17:77

    Published on: 26 April 2017

  7. Research article

    An experimental comparison of web-push vs. paper-only survey procedures for conducting an in-depth health survey of military spouses

    Previous research has found that a “web-push” approach to data collection, which involves contacting people by mail to request an Internet survey response while withholding a paper response option until later ...

    Hope Seib McMaster, Cynthia A. LeardMann, Steven Speigle and Don A. Dillman

    BMC Medical Research Methodology 2017 17:73

    Published on: 26 April 2017

  8. Technical advance

    Assessing the complexity of interventions within systematic reviews: development, content and use of a new tool (iCAT_SR)

    Health interventions fall along a spectrum from simple to more complex. There is wide interest in methods for reviewing ‘complex interventions’, but few transparent approaches for assessing intervention comple...

    Simon Lewin, Maggie Hendry, Jackie Chandler, Andrew D. Oxman, Susan Michie, Sasha Shepperd, Barnaby C. Reeves, Peter Tugwell, Karin Hannes, Eva A. Rehfuess, Vivien Welch, Joanne E. Mckenzie, Belinda Burford, Jennifer Petkovic, Laurie M. Anderson, Janet Harris…

    BMC Medical Research Methodology 2017 17:76

    Published on: 26 April 2017

  9. Research article

    Measurement properties of the Danish version of the Awareness and Beliefs about Cancer (ABC) measure

    The International Cancer Benchmarking Partnership aims to study international differences in cancer survival and the possible causes. Participating countries are Australia, Canada, Norway, Sweden, Denmark and ...

    Line Hvidberg, Anette Fischer Pedersen, Christian Nielsen Wulff, Anders Helles Carlsen and Peter Vedsted

    BMC Medical Research Methodology 2017 17:74

    Published on: 26 April 2017

  10. Research article

    Assessing the impact of natural policy experiments on socioeconomic inequalities in health: how to apply commonly used quantitative analytical methods?

    The scientific evidence-base for policies to tackle health inequalities is limited. Natural policy experiments (NPE) have drawn increasing attention as a means to evaluating the effects of policies on health. ...

    Yannan Hu, Frank J. van Lenthe, Rasmus Hoffmann, Karen van Hedel and Johan P. Mackenbach

    BMC Medical Research Methodology 2017 17:68

    Published on: 20 April 2017

  11. Research article

    Does the association between adherence to statin medications and mortality depend on measurement approach? A retrospective cohort study

    The aim of this study was to examine the relationship between mortality and statin adherence using two different approaches to adherence measurement (summary versus repeated-measures).

    Mhd. Wasem Alsabbagh, Dean Eurich, Lisa M. Lix, Thomas W. Wilson and David F. Blackburn

    BMC Medical Research Methodology 2017 17:66

    Published on: 20 April 2017

  12. Research article

    Evaluation of a modified version of the Posttraumatic Growth Inventory-Short Form

    Posttraumatic growth is the positive change resulting from traumatic experiences and is typically assessed with retrospective measures like the Posttraumatic Growth Inventory (PTGI). The PTGI was designed to i...

    Navjot Kaur, Ben Porter, Cynthia A. LeardMann, Laura E. Tobin, Hector Lemus and David D. Luxton

    BMC Medical Research Methodology 2017 17:69

    Published on: 20 April 2017

  13. Research article

    The impact of the mode of survey administration on estimates of daily smoking for mobile phone only users

    Over the past decade, there have been substantial changes in landline and mobile phone ownership, with a substantial increase in the proportion of mobile-only households. Estimates of daily smoking rates for t...

    Joseph Hanna, Damien V. Cordery, David G. Steel, Walter Davis and Timothy C. Harrold

    BMC Medical Research Methodology 2017 17:65

    Published on: 20 April 2017

  14. Study protocol

    Protocol for the development of a salutogenic intrapartum core outcome set (SIPCOS)

    Maternity intrapartum care research and clinical care more often focus on outcomes that minimise or prevent adverse health rather than on what constitutes positive health and wellbeing (salutogenesis). This wa...

    Valerie Smith, Deirdre Daly, Ingela Lundgren, Tine Eri, Cecily Begley, Mechthild M. Gross, Soo Downe, Zarko Alfirevic and Declan Devane

    BMC Medical Research Methodology 2017 17:61

    Published on: 19 April 2017

  15. Research article

    Kappa statistic to measure agreement beyond chance in free-response assessments

    The usual kappa statistic requires that all observations be enumerated. However, in free-response assessments, only positive (or abnormal) findings are notified, but negative (or normal) findings are not. This...

    Marc Carpentier, Christophe Combescure, Laura Merlini and Thomas V. Perneger

    BMC Medical Research Methodology 2017 17:62

    Published on: 19 April 2017

  16. Research article

    Grey literature in systematic reviews: a cross-sectional study of the contribution of non-English reports, unpublished studies and dissertations to the results of meta-analyses in child-relevant reviews

    Systematic reviews (SRs) are an important source of information about healthcare interventions. A key component of a well-conducted SR is a comprehensive literature search. There is limited evidence on the con...

    Lisa Hartling, Robin Featherstone, Megan Nuspl, Kassi Shave, Donna M. Dryden and Ben Vandermeer

    BMC Medical Research Methodology 2017 17:64

    Published on: 19 April 2017

  17. Research article

    Review and evaluation of performance measures for survival prediction models in external validation settings

    When developing a prediction model for survival data it is essential to validate its performance in external validation settings using appropriate performance measures. Although a number of such measures have ...

    M. Shafiqur Rahman, Gareth Ambler, Babak Choodari-Oskooei and Rumana Z. Omar

    BMC Medical Research Methodology 2017 17:60

    Published on: 18 April 2017

  18. Research article

    Clinical patient registry recruitment and retention: a survey of patients in two chronic disease registries

    The collection of routine clinical data in the setting of research registries can serve an important role in understanding real world care. However, relatively little is known about the patient experience in r...

    Daniel H. Solomon, Nancy A. Shadick, Michael E. Weinblatt, Michelle Frits, Christine Iannaccone, Agnes Zak and Joshua R. Korzenik

    BMC Medical Research Methodology 2017 17:59

    Published on: 17 April 2017

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