Table 2 Change in symptom domains per standard validated measures by RAD reasons for study drug discontinuation
Groups based on RAD-Q (Clinicians) | Groups based on RAD-I (Patients) | |||||||
|---|---|---|---|---|---|---|---|---|
RAD domain | Item | Comparator | N | Mean change (SE) | p-value | N | Mean change (SE) | p-value |
Positive Symptoms | Not Sufficiently Improved | PANSS Positive | ||||||
Yes | 56 | −3.2 (0.8) | 43 | −3.5 (0.8) | ||||
No | 103 | −6.8 (0.5) | .001 | 117 | −6.3 (0.5) | .003 | ||
Positive Symptoms | Worsened | PANSS Positive | ||||||
Yes | 13 | −1.8 (2.2) | 16 | −2.1 (1.6) | ||||
No | 149 | −5.9 (0.4) | .089 | 144 | −6.1 (0.4) | .004 | ||
Negative Symptoms | Not Sufficiently Improved | PANSS Negative | ||||||
Yes | 30 | −0.8 (0.8) | 23 | −2.5 (1.0) | ||||
No | 124 | −3.4 (0.5) | .012 | 132 | −2.9 (0.4) | .738 | ||
Negative Symptoms | Worsened | PANSS Negative | ||||||
Yes | 6 | −0.8 (1.3) | 8 | 2.5 (1.1) | ||||
No | 155 | −2.9 (0.4) | .330 | 147 | −2.9 (0.4) | .003 | ||
Mood Symptoms | Not Sufficiently Improved | PANSS Anxiety/Depression | ||||||
Yes | 24 | −0.7 (0.8) | 18 | −2.2 (1.1) | ||||
No | 138 | −2.6 (0.3) | .031 | 130 | −2.4 (0.4) | .866 | ||
Mood Symptoms | Worsened | PANSS Anxiety/Depression | ||||||
Yes | 13 | −0.4 (1.8) | 13 | −2.2 (1.1) | ||||
No | 149 | −2.5 (0.3) | .273 | 146 | −2.6 (0.3) | .743 | ||
Cognition | Not Sufficiently Improved | PANSS Cognition | ||||||
Yes | 16 | −2.7 (1.3) | 22 | −0.6 (1.0) | ||||
No | 142 | −3.2 (0.4) | .712 | 136 | −3.4 (0.4) | .014 | ||
Cognition | Worsened | PANSS Cognition | ||||||
Yes | 7 | −2.1 (1.5) | 14 | 0.8 (1.5) | ||||
No | 158 | −3.1 (0.4) | .607 | 145 | −3.3 (0.4) | .004 | ||
Functioning | Not Sufficiently Improved | QLS Total Score | ||||||
Yes | 21 | −7.7 (4.8) | 18 | −7.6 (5.1) | ||||
No | 135 | 4.6 (1.5) | .005 | 136 | 3.8 (1.5) | .015 | ||
Functioning | Worsened | QLS Total Score | ||||||
Yes | 9 | −15.2 (7.4) | 12 | −14.6 (6.2) | ||||
No | 152 | 3.7 (1.4) | .003 | 145 | 3.6 (1.4) | .001 | ||
Social Support | Friend/Family Did Not Support | QLS Interpersonal Relations | ||||||
Yes | 6 | −9.0 (3.5) | 10 | −4.3 (2.9) | ||||
No | 154 | 1.8 (0.7) | .003 | 158 | 2.3 (0.7) | .021 | ||
General Symptoms | Subject Believed Symptoms Worse | PANSS Total Score | ||||||
Yes | 21 | 0.6 (4.4) | ||||||
No | 142 | −17.3 (1.4) | .001 | |||||
Adherence | Subject Not Adhering to Medication | SCAP Adherence Item | ||||||
Yes | 11 | 2.0 (0.3) | ||||||
No | 133 | 1.4 (0.1) | .023 | |||||