From: A framework for organizing and selecting quantitative approaches for benefit-harm assessment
Approaches for B&H assessment | BLRA[22] | Boers[23] | Gail[3] | NCB[28] | PSM[29] | QFRBA[6] | RBC[31] | RBP[32] | TURBO[11] | Number of approaches in each category | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Key characteristics | |||||||||||||||||
Types of data | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Require individual patient data | Yes | Yes | No | No | No | No | No | No | No | No | No | No | No | No | Yes | No | Indiv: 3 |
No: 13 | |||||||||||||||||
Types of analyses | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Data driven (DD) versus simulation (S) | DD | NA | DD/S | DD | DD | DD | DD/S | DD | S | DD | DD | DD/S | DD | DD | DD | DD | DD: 14 |
S: 4 | |||||||||||||||||
Types of B&H metrics | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Absolute versus relative measures versus QALY versus other (O) | Other | A | A | QALY | A / relative | A | A | A | A | A / relative | A /QALY | A | A | A | A | A / relative | Absolute: 14 |
Relative: 3 | |||||||||||||||||
QALY: 2 | |||||||||||||||||
Assumptions | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Put B&H outcomes on same scale | yes | no | yes | yes | yes | yes | yes | yes | yes | no | yes | no | yes | yes | no | yes | Yes: 12 |
No:4 | |||||||||||||||||
Uncertainty estimates for B&H assessment | no | no | no | no | yes | no | yes | no* | yes | NA | no | yes | no | no | NA | no | Yes: 4 |
No: 12 | |||||||||||||||||
Joint distribution of B&H outcomes considered for uncertainty estimates | no | NA. | P | NA | no | NA | no | no | P | NA | NA | P | P | no | NA | NA | Possible: 4 |
No: 4 | |||||||||||||||||
n.a.: 8 | |||||||||||||||||
Multiple endpoints versus composite outcomes for B&H | M | Comp | M | M | M | M | M | M/ Comp | M | M | M | M | Comp | M | M | Comp | Multiple:12 |
Comp: 5 | |||||||||||||||||
Consideration of preferences | |||||||||||||||||
Explicitly considers preferences for B&H assessment: | yes | no | yes | no | yes | both | yes | no | both | no | yes | no | no | yes | yes | no | Yes: 9 |
No:9 | |||||||||||||||||
Types of presenting benefit risk comparison | |||||||||||||||||
B&H difference versus B&H ratio versus Time gained/lost versus B&H graphic versus other | D | Graphic | D | D | D, ratio, other | D | D | Ratio | D | D, ratio, other | Time, D | Graphic | Graphic | Ratio | D | Graphic | Difference: 10 |
Ratio: 4 | |||||||||||||||||
Time: 1 | |||||||||||||||||
Graphic: 3 |