Number of studies | |
Balanced direct comparisons | KAB = KAC = KBC = 1, …, 7 |
Imbalanced direct comparisons | KAB = 1, KAC = 4, KBC = 7 (and KAB = 1, KAC = 4, KBC = 3 for the typical loop) |
Treatment effects | |
Comparison AB | ORAB = 0.73 |
Comparison AC | ORAC = 1 |
Comparison BC | ORBC = exp{log(ORAC) - log(ORAB) + IFABC} |
Inconsistency in the network | |
Inconsistency Factor | IFABC = {0, 0.3, 0.45, 0.6, 1} |
Heterogeneity in the network | |
Subjective outcome | Ï„2 ~ LN(-2.13, 1.582) |
All-cause mortality outcome | Ï„2 ~ LN(-4.06, 1.452) |
Trial arm size | |
Small | n ~ U(20, 50) |
Moderate | n ~ U(50, 150) |
Large | n ~ U(150, 300) (and n ~ U(120, 160) for the typical loop) |
Frequency of events | |
Average risk for frequent events |
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Average risk for rare events |
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Approaches to estimate the variances of the direct pairwise summary effects | |
Inverse variance method | Â |
Knapp-Hartung method | Â |