BMC Medical Research Methodology

Table 1 True marginal probability of toxicity, marginal probability of efficacy and D ( z ) for each dose level

From: Evaluating the performance of copula models in phase I-II clinical trials under model misspecification

Scenario				Dose
		1	2	3	4
1	P(Toxicity)	0.05	0.12	0.27	0.50
	P(Efficacy)	0.38	0.55	0.71	0.83
	D(z)	-0.38	-0.03	0.16	-0.07
2	P(Toxicity)	0.38	0.52	0.67	0.79
	P(Efficacy)	0.77	0.82	0.86	0.89
	D(z)	0.08	-0.11	-0.38	-0.6
3	P(Toxicity)	0.02	0.07	0.15	0.31
	P(Efficacy)	0.12	0.25	0.45	0.67
	D(z)	-0.96	-0.67	-0.26	0.04
4	P(Toxicity)	0.05	0.11	0.25	0.46
	P(Efficacy)	0.18	0.55	0.79	0.86
	D(z)	-0.82	-0.02	0.32	0.03
5	P(Toxicity)	0.03	0.08	0.18	0.38
	P(Efficacy)	0.18	0.25	0.33	0.43
	D(z)	-0.82	-0.67	-0.53	-0.48

Optimal dose is in bold.

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