No role for quality scores in systematic reviews of diagnostic accuracy studies

Whiting, Penny; Harbord, Roger; Kleijnen, Jos

doi:10.1186/1471-2288-5-19

BMC Medical Research Methodology

Table 2 Individual study results (2 × 2 data), results of the quality assessment, and quality scores using each of the five scoring schemes

From: No role for quality scores in systematic reviews of diagnostic accuracy studies

Study details	2 × 2 Data				QUADAS Results														Quality score
	TP	FP	FN	TN	Spectrum composition	Selection criteria	Reference standard	Disease progression bias	Partial verification bias	Differential verification bias	Incorporation bias	Test execution details	Reference execution details	Test review bias	Diagnostic review bias	Clinical review bias	Uninterpretable results	Withdrawals	Score 1	Score 2	Score 3	Score 4	Score 5
Standard US
Baronciani (1986) [24]	13	4	8	49	+	+	+	?	+	+	+	-	-	?	?	?	?	?	43	64	45	46	53
Dura (1997) [25]	3	4	14	27	-	+	+	+	+	+	+	+	+	+	+	?	+	+	86	89	85	77	79
Evans (1999) [26]	2	10	17	84	-	+	+	?	+	+	+	+	-	?	?	?	+	?	50	68	48	42	49
Foresman (2001) [27]	24	43	25	47	-	+	+	+	+	+	+	+	-	+	+	?	+	+	79	82	79	73	76
Mage (1989) [28]	22	5	19	76	-	-	+	?	+	+	+	+	-	?	?	?	?	?	36	57	42	35	42
Mahant (2002) [29]	14	30	21	97	-	+	+	+	+	+	+	+	-	+	+	?	?	?	64	75	73	65	68
Morin (1999) [30]	20	41	2	7	-	+	+	+	+	+	+	+	-	?	?	?	?	?	50	68	55	42	52
Muensterer (2002) [31]	35	76	34	241	-	+	+	+	+	+	+	+	-	?	?	?	?	+	57	71	58	46	55
Oostenbrink (2000) [32]	21	20	16	83	+	+	+	?	-	?	+	+	-	+	?	?	?	-	43	61	42	42	47
Salih (1994) [33]	26	3	1	12	+	-	+	+	+	+	+	-	-	?	?	?	?	-	43	57	52	46	58
Tan (1988) [34]	3	6	14	32	-	-	+	+	+	+	+	+	+	-	-	?	?	?	50	61	58	42	52
Verber (1988) [35]	8	9	20	25	+	-	+	?	-	+	+	+	+	?	?	?	?	-	43	61	45	38	46
Median Score																			50	66	53	44	52
Contrast-enhanced US
Alzen (1994) [36]	20	6	2	73	-	-	+	+	+	+	+	-	-	?	?	?	?	?	36	54	45	35	46
Bergius (1990) [23]	56	2	14	176	+	-	+	?	+	+	+	+	-	+	+	+	?	-	64	71	76	81	76
Berrocal (2001) [37]	94	29	10	307	-	-	+	+	+	+	+	+	-	?	?	?	?	?	43	61	52	38	49
Berrocal Frutos (2000) [38]	63	19	7	204	-	+	+	+	+	+	+	+	+	+	+	?	+	+	86	89	85	77	79
Haberlick (1997) [39]	21	10	9	114	-	+	+	+	+	+	+	+	-	?	?	?	?	?	50	68	55	42	52
Kessler (1982) [40]	13	0	4	38	-	+	+	?	-	+	+	+	-	+	?	?	?	-	43	57	45	38	44
McEwing (2002) [41]	8	3	8	173	-	+	+	+	+	+	+	+	-	+	+	?	?	+	71	79	76	69	72
Mentzel (2002) [42]	36	10	4	174	-	-	+	+	+	+	+	+	+	+	?	?	+	+	71	79	73	62	69
Nakamura (2002) [43]	9	3	2	52	-	-	+	?	+	+	+	+	-	+	+	?	?	?	50	64	61	58	59
Piaggio (2003) [44]	42	35	32	196	-	+	+	?	+	+	+	+	+	?	?	+	?	+	64	79	64	58	56
Radmayr (2002) [44]	71	5	3	129	-	-	+	+	+	+	+	+	+	+	+	?	+	+	79	82	82	73	76
Schneider (1984) [45]	46	15	17	141	-	+	+	+	+	+	+	+	+	+	+	?	?	?	71	82	79	69	71
Siamplis (1996) [46]	15	4	3	154	-	+	+	+	+	+	+	+	-	?	?	?	+	?	57	71	58	46	56
Valentini (2001) [47]	34	4	8	72	-	-	+	+	+	+	+	+	+	-	-	?	?	?	50	61	58	42	52
Uhl (2003) [48]	16	0	3	28	+	+	+	+	+	+	+	-	-	+	?	?	+	?	64	75	67	65	74
Von Rohden (1995) [49]	6	0	1	19	-	+	+	+	+	+	+	+	+	+	+	?	+	+	86	89	85	77	79
Median score																			64	73	65	60	64

TP = true positives; FP = false positives; FN = false negatives; TN = true negatives + = yes; - = no; ? = unclear

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ISSN: 1471-2288

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