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Table 1 ASN required to reach a conclusion under H0/H1, and when θ = θR/2 for the TT (R = 1), TT (R = 2), DTT (R = 1) and DTT (R = 2) and sample size for the SSD (R = 1) and SSD (R = 2), for different values of θR, β (α = 0.05) and n = 12.

From: Sequential boundaries approach in clinical trials with unequal allocation ratios

θR

β

SSD R = 1

SSD R = 2

TT(R = 1)

TT(R = 2)

DTT(R = 1)

DTT(R = 2)

    

ASN (H0/H1)

ASN (θR/2)

ASN (H0/H1)

ASN (θR/2)

ASN (H0/H1)

ASN (θR/2)

ASN (H0/H1)

ASN (θR/2)

0.4

0.05

325

366

168/185

239

188/208

269

220/184

247

248/208

273

 

0.1

263

296

135/164

191

152/184

215

179/165

199

201/185

224

0.5

0.05

208

234

108/120

155

122/134

173

143/120

159

160/135

179

 

0.1

168

189

88/107

124

98/120

139

116/108

129

129/120

145

0.6

0.05

144

163

77/85

109

86/95

122

100/86

112

113/95

125

 

0.1

117

131

62/76

87

69/85

98

82/76

90

92/85

102

0.7

0.05

106

119

57/64

81

64/71

91

75/64

84

84/72

93

 

0.1

86

97

47/57

65

52/64

73

61/57

68

68/64

76

0.8

0.05

81

91

45/50

63

50/56

70

59/50

65

63/56

71

 

0.1

66

74

37/45

51

41/50

57

46/44

51

53/50

59

0.9

0.05

64

72

36/41

51

40/45

56

46/41

51

52/45

58

 

0.1

52

58

30/37

41

33/41

46

39/37

42

43/41

48

1.0

0.05

52

58

30/34

42

34/38

47

39/35

43

44/38

48

 

0.1

42

47

25/31

34

28/34

38

29/29

32

36/34

39