From: Sequential boundaries approach in clinical trials with unequal allocation ratios
θR | β | SSD R = 1 | SSD R = 2 | TT(R = 1) | TT(R = 2) | DTT(R = 1) | DTT(R = 2) | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
ASN (H0/H1) | ASN (θR/2) | ASN (H0/H1) | ASN (θR/2) | ASN (H0/H1) | ASN (θR/2) | ASN (H0/H1) | ASN (θR/2) | ||||
0.4 | 0.05 | 325 | 366 | 168/185 | 239 | 188/208 | 269 | 220/184 | 247 | 248/208 | 273 |
0.1 | 263 | 296 | 135/164 | 191 | 152/184 | 215 | 179/165 | 199 | 201/185 | 224 | |
0.5 | 0.05 | 208 | 234 | 108/120 | 155 | 122/134 | 173 | 143/120 | 159 | 160/135 | 179 |
0.1 | 168 | 189 | 88/107 | 124 | 98/120 | 139 | 116/108 | 129 | 129/120 | 145 | |
0.6 | 0.05 | 144 | 163 | 77/85 | 109 | 86/95 | 122 | 100/86 | 112 | 113/95 | 125 |
0.1 | 117 | 131 | 62/76 | 87 | 69/85 | 98 | 82/76 | 90 | 92/85 | 102 | |
0.7 | 0.05 | 106 | 119 | 57/64 | 81 | 64/71 | 91 | 75/64 | 84 | 84/72 | 93 |
0.1 | 86 | 97 | 47/57 | 65 | 52/64 | 73 | 61/57 | 68 | 68/64 | 76 | |
0.8 | 0.05 | 81 | 91 | 45/50 | 63 | 50/56 | 70 | 59/50 | 65 | 63/56 | 71 |
0.1 | 66 | 74 | 37/45 | 51 | 41/50 | 57 | 46/44 | 51 | 53/50 | 59 | |
0.9 | 0.05 | 64 | 72 | 36/41 | 51 | 40/45 | 56 | 46/41 | 51 | 52/45 | 58 |
0.1 | 52 | 58 | 30/37 | 41 | 33/41 | 46 | 39/37 | 42 | 43/41 | 48 | |
1.0 | 0.05 | 52 | 58 | 30/34 | 42 | 34/38 | 47 | 39/35 | 43 | 44/38 | 48 |
0.1 | 42 | 47 | 25/31 | 34 | 28/34 | 38 | 29/29 | 32 | 36/34 | 39 |