Figure 2

Simulation Extrapolation (SIMEX) plot of corrected coefficients for model with 3H as the exposure and Word Fluency Test (WFT) decline as the outcome: two approaches; ARIC (1987–98)¹. w: 3H; x: 6H; _cons: intercept in the model: Logit(Y = 1) = _cons + β _naive1Q_1(3H) + β _naive2Q_1(6H) where Y = decline in Word Fluency Test (WFT) based on the RCI < -1.645 criterion. Lambda: scale factors used to add error to the error-prone variable Q₁. Error variance (needed for the SIMEX procedure) is estimated internally using Approach A: {Q₁, M/N} or Approach B: {Q₁, Q₂/Q₃}.