Reporting of Human Genome Epidemiology (HuGE) association studies: An empirical assessment

Table 6 Reporting characteristics for the analysis of interacting environmental factors for randomly selected HuGE articles (2001–2003)

Reporting characteristic	Count*	Percent
Number of environmental factors assessed in gene-environment interactions
1	34	70.8
2	10	20.8
>= 3	4	8.4
Potential for misclassification of the environmental factors
No	7	14.6
Unclear	4	8.3
Yes	37	77.1
Provided a description of possible error in the measurement of the environmental factor
No	45	93.8
Yes	3	6.2
Use of dose-depending models
No	45	93.8
Yes	3	6.2
Reported that the evaluation of the genetic test was blind to the environmental factor
Blind	0	0.0
Unclear	48	100.0
Reported that the evaluation of the environmental factor was blind to the genetic test
Blind	0	0.0
Unclear	48	100.0
If gene-environmental interactions were assessed, was risk quantified as an odds ratio or risk ratio
No	22	45.8
Yes	26	54.2
If gene-environmental interactions were assessed, was risk quantified as an absolute difference
No	48	100.0
Yes	0	0.0
If gene-environmental interactions were assessed, was risk quantified as an attributable fraction
No	48	100.0
Yes	0	0.0
Claim of a statistically significant gene-environmental interaction
No	34	70.8
Yes	14	29.2

ISSN: 1471-2288