Systematic review | Interventions | Wound types | Clinical outcomes | Clinical study design | Sample size restrictions | Type of study information considered | Prespecified search for HTAs/SRs | Language restrictions |
---|---|---|---|---|---|---|---|---|
Samson/AHRQ 2004 [29] | a) NPWT vs. other wound healing interventions b) NPWT + standard care vs. standard wound care alone c) NPWT vs. sham intervention | Chronic wounds: - pressure ulcers - metabolic disorders (e.g., diabetes mellitus) - vascular insufficiency - inflammatory disorders - malignancies - infections - miscellaneous (e.g., burns) Other types of wounds: - acute wounds - traumatic wounds - subacute wounds - dehisced wounds - partial thickness burns - diabetic ulcers - pressure ulcers - flaps - grafts | Primary outcomes: - incidence of complete wound closure - time to complete closure - adverse events Secondary outcomes: - facilitating surgical closure - need for debridement - infections - pain - activities of daily living - quality of life - improved cosmesis - change in wound size* - transcutaneous oxygen tension* | RCT | None | Articles | - | Abstracts published in English; articles without abstracts were reviewed if title indicated that articles met inclusion criteria; non-English articles were reviewed if English abstract indicated that articles met inclusion criteria. |
Costa/MUHC TAU 2005 [30]†| NPWT vs. other treatment alternatives | Not prespecified in detail | Not prespecified in detail ("clinical effectiveness") | RCT Non-RCT (clinical comparative studies) | ≥ 9 patients in either arm‡ | Articles | + | Articles published in English or French |
IQWiG 2006 [8] | NPWT vs. a) conventional wound therapy b) another type of NPWT | Acute or chronic wounds | - wound healing time - wound recurrence - revision operations - amputations - mortality - disease-related quality of life - activities of everyday life - pain - time spent in hospital - dressing changes - debridement procedures - adverse events - scar formation - subjective cosmetic results | RCT Non-RCT with a concurrent control group (clinical controlled trials, comparative cohort studies, case control studies) | None | Articles Unpublished data provided by manufacturers§ | + | Language restrictions were not specified in the IQWiG review.|| |
Pham/ASERNI P-S 2006 update [31]¶| | NPWT vs. conventional methods | Particular wound types** - pressure ulcers and leg ulcers - diabetic foot ulcers and wounds - skin grafts - chronic wounds and complex/severe wounds - sternal wounds | Not prespecified in detail ("efficacy and safety outcomes") | RCT Non-RCT (other controlled or comparative studies and case series with consecutive patients) | None | Articles Conference abstracts††Manufacturer's information††| - | Searches were conducted without language restriction. English abstracts from non-English articles were included if they met the inclusion criteria and included efficacy and safety data.‡‡ |
OHTAC 2006 (update) [32]§§ | NPWT vs. standard care | Wounds, including - Pressure ulcers - diabetic ulcers - sternal wounds - skin grafts | Not prespecified in detail ("Is negative pressure wound therapy effective for healing wounds...?") | RCT | ≥ 20 patients | Articles ("peer-reviewed, published") | + | Articles published in English |