Table 2 Chart-based studies of sepsis and severe sepsis incidence in the general population
From: Differences in reported sepsis incidence according to study design: a literature review
Padkin, 2003 [54] | Finfer, 2004 [48] | Brun-Buisson, 2004 [45] | Harrison, 2006 [53] | Esteban, 2007 [47] | Karlsson, 2007 [50] | Blanco, 2008 [44] | Vesteinsdottir, 2011 [52] | Davis, 2011 [46] | Nygard, 2014 [51] | Henriksen, 2015 [49] | |
|---|---|---|---|---|---|---|---|---|---|---|---|
Country/region | England, Wales and Northern Ireland | Australia and New Zealand | France | England, Wales and Northern Ireland | Madrid, Spain | Finland | Castilla y Leòn Region, Spain | Iceland | Northern territory, Australia | Norway | Denmark |
Setting | 91 ICUs | 23 ICUs | 206 ICUs | 172 ICUs | 3 hospitals | 24 ICUs/11 hospitals | 11 ICUs | 3 ICUs | 1 hospital | 3 ICUs | 1 ED |
Study population | 56,673 | 5,878 | 3,738 | 343,860 | 15,852 | 4,500 | 2,619 | 1,524 | 15,963 | NA | 8,358 |
Number of cases (sepsis/severe sepsis) | NA/15,362 | NA/691 | NA/621 | NA/92,672 | 702/199 | NA/472 | NA/246 | NA/115 | 1,191/272 | NA/220 | 621/1,071 |
Study duration | 1995–2000 | 3 months | 2 weeks | 10 year | 4 months | 4 months /4 days | 6 months | 1 year | 1 year | 1 year | 1 year |
Exclusion criteria | <16 years, readmissions, sepsis not present within 24 h from admission | <15 years | <16 years, readmissions, sepsis not present within 24 h from admission | < 18 years | < 18 years, readmissions | <18 years | < 18 years, readmissions, sepsis not present on admission | < 15 years | < 15 years, severe sepsis not present within 24 h from admission, transferred with diagnosis of severe sepsis | < 15 years, readmissions, immediately preceding hospitalisation | |
Sepsis inclusion criteria | PROWESS | Bone criteria | Bone criteria | PROWESS | Bone criteria | Bone criteria | Bone criteria | Bone criteria | PROWESS | Bone criteria | Bone criteria |
Organ failure inclusion criteria | Modified PROWESS | Modified PROWESS | SOFA score ≥3 | Modified PROWESS | MODS score >2 | SOFA score ≥3 | Modified PROWESS | Modified Bone criteria | PROWESS | Modified Levy et al. | Protocol specified criteria |
Calendar yeari | 1997ii | 1999 | 2001 | 1996; 2003 | 2003 | 2005 | 2002 | 2009 | 2008 | 2008 | 2011 |
Sepsis incidence 100.000 person yrs−1 | – | – | – | – | 367 | – | – | – | 1,180 | – | 265 |
Severe sepsis incidence 100.000 person yrs−1 | 51 | 77 | 95 | 46; 66 | 104 | 38 | 25 | 48 | 130 | 50 | 457 |