Least absolute shrinkage and selection operator type methods for the identification of serum biomarkers of overweight and obesity: simulation and application

Vasquez, Monica M.; Hu, Chengcheng; Roe, Denise J.; Chen, Zhao; Halonen, Marilyn; Guerra, Stefano

doi:10.1186/s12874-016-0254-8

Table 6 TESAOD analysis, coefficients refer to associations of standardized biomarker values with overweight and obese separately

From: Least absolute shrinkage and selection operator type methods for the identification of serum biomarkers of overweight and obesity: simulation and application

	Overweight							Obese
	(N = 463 normal-weight, N = 306 overweight)							(N = 463 normal-weight, N = 66 obese)
	LASSO	Adaptive LASSO	Elastic Net	Iterated LASSO	Bootstrap-Enhanced LASSO-75	Weighted Fusion	p^	LASSO	Adaptive LASSO	Elastic Net	Iterated LASSO	Bootstrap-Enhanced LASSO-75	Weighted Fusion	p^
Adiponectin	−0.2511	−0.3500	−0.2498	−0.3297	−0.3226	−0.2440	**	−0.0101	0	−0.0006	0	0	−0.0853	*
Apolipoprotein H	0.0571	0.0838	0.0762	0.1479	0.1309	0.0512	**	0.0881	0.1642	0.0346	0	0.2160	0.1277	**
Calcitonin^a	0.0469	0.0765	0.0668	0.1681	0.0895	0.0352	*	0	0	0	0	0	0.0624
Soluble CD14	−0.1133	−0.1679	−0.1296	−0.2492	−0.1923	−0.0994	*	−0.1020	−0.1706	−0.0488	0	−0.2272	−0.0965
Complement 3	0.0847	0.1238	0.1183	0.2080	0.1483	0.0767	**	0.0899	0	0.0761	0	0	0.1306	**
C-Reactive Protein	0.2105	0.3150	0.2188	0.3791	0.2901	0.1923	**	0.5213	0.7636	0.4765	0.6802	0.6052	0.2526	**
Ferritin	0.1131	0.0969	0.1120	0.1431	0.1055	0.1115	**	0.0753	0	0.0469	0	0	0.0671	*
Growth Hormone	−0.1163	−0.1238	−0.1259	−0.1737	−0.1566	−0.1144	**	0	0	0	0	0	−0.0888	*
Immunoglobulin M	−0.0410	−0.0288	−0.0569	−0.1228	−0.0949	−0.0320	*	−0.1014	0	−0.0450	0	0	−0.1120
Interleukin-18	0.0073	0.0047	0.0348	0.1515	0	0	**	0.1214	0.0653	0.0804	0.0774	0.2373	0.0870	*
Leptin	0.2057	0.3263	0.2102	0.3690	0.3177	0.1829	**	0.9186	1.1286	0.8548	1.2502	1.1551	0.3792	**
Monocyte Chemotactic Protein-1	0	0	0	0	0	0		0.1628	0.1471	0.1269	0.1792	0.2546	0.1275	**
Myoglobin	0.2323	0.3468	0.2300	0.3341	0.2856	0.2162	**	0.0391	0	0.0316	0	0	0.0829	*
Sex Hormone Binding Globulin	−0.2130	−0.2033	−0.1979	−0.2220	−0.2046	−0.2009	**	−0.4768	−0.6470	−0.4499	−0.7274	−0.4767	−0.2334	**
Surfactant Protein D	−0.1053	−0.1518	−0.1250	−0.2361	−0.2089	−0.0924	*	−0.3136	−0.4086	−0.2351	−0.3848	−0.4663	−0.2820	**
von Willebrand Factor	0	0	0	0	0	0		0.1980	0.0683	0.1737	0.2571	0.2694	0.1364	**
YKL-40	0	0	0.0108	0	0	0		0.1095	0.0847	0.0733	0.0314	0.1979	0.1151	**

^aCategorized at median; ^: p-value for univariate association from binary logistic regression; *: p < 0.05; **: p < 0.01

Back to article page

ISSN: 1471-2288

Contact us

General enquiries: journalsubmissions@springernature.com

BMC Medical Research Methodology

Contact us