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Table 3 After observing 3TTT in cohort 1, cohort 2 is recommended to receive dose-level 2

From: Implementing the EffTox dose-finding design in the Matchpoint trial

Cohort 2 outcomes

Dose for cohort 3

2NNN

3

2NNE

1

2NNT

Stop trial

2NNB

1

2NEE

1

2NET

1

2NEB

1

2NTT

Stop trial

2NTB

1

2NBB

1

2EEE

1

2EET

1

2EEB

1

2ETT

1

2ETB

1

2EBB

1

2TTT

Stop trial

2TTB

1

2TBB

1

2BBB

1

  1. The dose recommended for cohort 3 depends on the outcomes in cohort 2, as depicted by these dose transition pathways