Table 2 Univariate Cox regression analysis and multivariate Cox regression analysis

Gender

 Female

Reference

Reference

 Male

0.799

2.224 (1.864–2.654)

<0.001

0.074

1.077 (0.839–1.383)

0.560

Age

  (18,44]

Reference

Reference

  (44,59]

0.784

2.190 (1.117–4.296)

0.023

−0.037

0.964 (0.487–1.909)

0.916

  (59,74]

1.107

3.025 (1.560–5.865)

0.001

0.108

1.114 (0.567–2.191)

0.754

  (74,92]

1.758

5.800 (2.897–11.612)

<0.001

0.509

1.664 (0.822–3.372)

0.157

Smoking

 Never

Reference

Reference

 Current

1.033

2.809 (2.321–3.398)

<0.001

0.585

1.795 (1.306–2.466)

<0.001

 Former

0.628

1.874 (1.497–2.345)

<0.001

0.186

1.205 (0.881–1.647)

0.243

Drinking

 no

Reference

Reference

 yes

0.686

1.986 (1.672–2.359)

<0.001

−0.172

0.842 (0.650–1.092)

0.195

NSCLC

 no

Reference

Reference

 yes

−1.117

0.327 (0.265–0.404)

<0.001

−0.09

0.914 (0.736–1.135)

0.416

Radiotherapy

0.431

1.539 (1.290–1.836)

<0.001

Chemotherapy

0.555

1.743 (1.475–2.060)

<0.001

Targeted therapy

0.656

1.928 (1.627–2.284)

<0.001

−0.459

0.632 (0.525–0.761)

<0.001

COPD

0.633

1.884 (1.591–2.230)

<0.001

0.195

1.216 (1.009–1.465)

0.040

Pneumonia

0.93

2.535 (2.145–2.996)

<0.001

0.125

1.133 (0.946–1.359)

0.176

Pleural effusion

1.063

2.894 (2.431–3.445)

<0.001

STAGE

 I

Reference

Reference

 II

1.888

6.607 (3.105–14.058)

<0.001

1.778

5.916 (2.771–12.631)

<0.001

 III

3.234

25.393 (14.608–44.140)

<0.001

3.027

20.644 (11.716–36.377)

<0.001

 IV

3.897

49.263 (28.908–83.952)

<0.001

3.716

41.091 (23.662–71.356)

<0.001

URI

−0.445

0.641 (0.443–0.926)

0.018

Lung abscess

0.876

2.402 (1.322–4.365)

0.004

Pulmonary embolism

1.138

3.121 (2.037–4.783)

<0.001

Pulmonary heart disease

1.013

2.753 (1.954–3.877)

<0.001

ILD

1.022

2.779 (1.980–3.899)

<0.001

0.416

1.515 (1.063–2.159)

0.021

Respiratory failure

1.368

3.926 (2.902–5.313)

<0.001

0.628

1.873 (1.362–2.577)

<0.001

Red blood cell count

 T₁

Reference

 T₂

0.517

1.678 (1.300–2.166)

<0.001

 T₃

1.039

2.825 (2.219–3.598)

<0.001

Eosinophil

 T₁

Reference

 T₂

0.517

1.678 (1.300–2.166)

<0.001

 T₃

1.039

2.825 (2.219–3.598)

<0.001

Fibrinogen

 T₁

Reference

Reference

 T₂

0.804

2.234 (1.711–2.917)

<0.001

0.276

1.318 (1.004–1.730)

0.047

 T₃

1.754

5.780 (4.537–7.363)

<0.001

0.57

1.769 (1.374–2.277)

<0.001

Direct bilirubin

 T₁

Reference

 T₂

−0.396

0.673 (0.556–0.816)

<0.001

 T₃

−0.774

0.461 (0.370–0.575)

<0.001