Table 2 Calculations of sequence ratios incorporating co-medication for the prescribing cascade of three cardiovascular medication groups-induced erectile dysfunction and patients using multiple groups

Any ACEi users^a

3,188

2,152

1,036

2.08

1.09

1.91 (1.84-1.99)

Sole ACEi users^b

1,170

767

403

1.90

1.09

1.74 (1.62-1.86)

Any beta blocker users

3,035

1,937

1,098

1.76

1.06

1.66 (1.58-1.73)

Sole beta blocker users

1,228

739

489

1.51

1.05

1.44 (1.33-1.56)

Any high ceiling diuretic users

688

405

283

1.43

1.04

1.38 (1.23-1.53)

Sole high ceiling diuretic users

342

200

142

1.41

1.04

1.36 (1.14-1.57)

Combination: use of two subgroups^c

2,419

1,695

724

2.34

1.07

2.18 (2.10-2.27)

Combination: use of three or more subgroups

1,544

1,167

377

3.10

1.10

2.81 (2.69-2.93)