Table 2 Trial characteristics (methods)

Target sample size info provided

187

106

57

350

 Small (≤ 100)

83 (44.4)

48 (45.3)

24 (42.1)

155 (44.3)

 Medium (101 to 300)

54 (28.9)

33 (31.1)

18 (31.6)

105 (30)

 Large (> 300)

50 (26.7)

25 (23.6)

15 (26.3)

90 (25.7)

Blinding info provided

170

108

19

297

 Blinding

82 (48.2)

40 (37.)

16 (84.2)

138 (46.5)

Blinding description info provided

79

40

16

135

 Single

14 (17.7)

11 (27.5)

2 (12.5)

27 (20)

 Double

32 (40.5)

19 (47.5)

8 (50)

59 (43.7)

 Triple/Quadruple

33 (41.8)

10 (25)

6 (37.5)

49 (36.3)

Allocation concealment info provided

12

12

11

35

 Allocation concealment

12 (100)

10 (83.3)

11 (100)

33 (94.3)

Ethics info provided

76

58

23

157

 Ethics approval

75 (98.7)

58 (100)

23 (100)

156 (99.4)

Trial status info provided

192

108

57

357

 Not stated/Unknown

18 (9.4)

6 (5.6)

4 (7)

28 (7.8)

 Ongoing

70 (36.5)

59 (54.6)

30 (52.6)

159 (44.5)

 Completed

34 (17.7)

20 (18.5)

18 (31.6)

72 (20.2)

 Withdrawn/Terminated

70 (36.4)

23 (21.3)

5 (8.8)

98 (27.5)