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Table 4 Summary of simulated patient numbers for each scenario

From: Implementing the time-to-event continual reassessment method in the presence of partial orders in a phase I head and neck cancer trial

Scenario

Max no. of patients

% max reached

Mean no. of patients

1: TD25 @-1

60

0.21

26.38

2: TD25 @0

60

0.08

29.97

3: TD25 @1

60

0.05

32.01

4: TD25 @2a

60

0.12

33.22

5: TD25 @2b

60

0.06

33.60

6: TD25 @3

60

0.02

30.92

7: Equal steps

60

0.01

31.74

8: All toxic

54

0.01

16.14

9: TD25 @-1

60

0.17

26.24

10: TD25 @0

60

0.11

29.95

11: TD25 @1

60

0.06

32.15

12: TD25 @2a

60

0.07

33.56

13: TD25 @2b

60

0.03

33.16

14: TD25 @3

60

0.08

30.81

15: Equal steps

60

0.02

31.69

16: All toxic

51

0.01

16.11