Table 1 Differences of seroresponse rates between high dose group and control group for the four co-primary endpoints
Scenarios | Endpoint 1 | Endpoint 2 | Endpoint 3 | Endpoint 4 | ||
|---|---|---|---|---|---|---|
Effective | p3 > pC | 1 | 0.02 | 0.02 | 0.02 | 0.02 |
2 | 0.02 | 0.02 | 0.02 | 0 | ||
3 | 0.02 | 0.02 | 0 | 0 | ||
4 | 0.02 | 0 | 0 | 0 | ||
p3 = pC | 5 | 0 | 0 | 0 | 0 | |
pC—0.1 < p3 < pC | 6 | -0.02 | 0 | 0 | 0 | |
7 | -0.02 | -0.02 | 0 | 0 | ||
8 | -0.02 | -0.02 | -0.02 | 0 | ||
9 | -0.02 | -0.02 | -0.02 | -0.02 | ||
Ineffective | p3—pC = -0.1 | - | -0.10 | -0.10 | -0.10 | -0.10 |