Fig. 1

The Portfolio Maintenance by Test-Treatment framework. The figure shows the framework depicted as a flow diagram in analogy to a diagnostic test-treatment pathway. Tests are performed (grey boxes, not outlined), choices are made (outlined orange diamonds), management options (outlined blue boxes) are selected based on indications (outlined yellow boxes), subsequent management actions are performed (blue boxes, not outlined), and predefined time intervals are used for reassessments (dashed line)