Table 3 Power to detect Gene × Environment (G×E) interactions.
| Â | SAMPLE SIZE = 1000 | SAMPLE SIZE = 2000 | ||||
|---|---|---|---|---|---|---|
|  | G×E interaction OR = 2 | G × E interaction OR = 2 | ||||
Allele frequency (%) | Binary environmental exposure prevalence (%) | Binary environmental exposure prevalence (%) | ||||
| Â | 20 | 30 | 40 | 20 | 30 | 40 |
10 | 37.6% | 45.8% | 49.5% | 64.2% | 74.6% | 78.6% |
20 | 49.8% | 58.9% | 62.2% | 79.0% | 87.1% | 89.4% |
30 | 50.4% | 58.7% | 61.2% | 79.6% | 87.0% | 88.7% |
|  | G × E interaction OR = 2.5 | G × E interaction OR = 2.5 | ||||
Allele frequency (%) | Binary environmental exposure prevalence | Binary environmental exposure prevalence | ||||
| Â | 20 | 30 | 40 | 20 | 30 | 40 |
10 | 57.2% | 67.9% | 72.3% | 85.7% | 92.9% | 95.0% |
20 | 72.6% | 81.7% | 84.3% | 95.2% | 98.2% | 98.7% |
30 | 73.3% | 81.3% | 83.1% | 95.5% | 98.1% | 98.5% |
|  | G × E interaction OR = 3 | G × E interaction OR = 3 | ||||
Allele frequency (%) | Binary environmental exposure prevalence | Binary environmental exposure prevalence | ||||
| Â | 20 | 30 | 40 | 20 | 30 | 40 |
10 | 71.4% | 81.9% | 85.7% | 94.7% | 98.2% | 99.0% |
20 | 85.9% | 92.5% | 94.1% | 99.0% | 99.8% | 99.9% |
30 | 86.6% | 92.2% | 93.1% | 99.1% | 99.8% | 99.8% |